Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Walter Knöchel"'
Autor:
Cristobal Alvarado, Jörg Wiedenmann, Uwe Knippschild, Bernd Baumann, Karen Clauß, Horst Hameister, Götz von Wichert, Walter Knöchel, Tilman Borggrefe, Franz Oswald, Stephan A. Wacker, Gerd Ulrich Nienhaus
Publikováno v:
The EMBO Journal. 30:43-56
The evolutionarily conserved Notch signal transduction pathway regulates fundamental cellular processes during embryonic development and in the adult. Ligand binding induces presenilin-dependent cleavage of the receptor and a subsequent nuclear trans
Publikováno v:
Journal of Biological Chemistry. 285:8408-8421
Xenopus Oct25 is a POU family subclass V (POU-V) transcription factor with a distinct domain structure. To investigate the contribution of different domains to the function of Oct25, we have performed gain of function analyses. Deletions of the N- or
FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis
Autor:
Maximilian Schuff, Nabila Bardine, Cornelia Donow, Doreen Siegel, Franz Oswald, Walter Knöchel
Publikováno v:
Developmental Biology. 337(2):259-273
Forkhead box (Fox) transcription factors of subclass O are involved in cell survival, proliferation, apoptosis, cell metabolism and prevention of oxidative stress. FoxO genes are highly conserved throughout evolution and their functions were analyzed
Publikováno v:
Mechanisms of Development. 126:974-989
The maintenance of pluripotency in mammalian embryonic stem cells depends upon the expression of regulatory genes like Oct3/4 and Sox2. While homologues of these genes are also characterized in non-mammalian vertebrates, like birds, amphibians and fi
Autor:
Walter Knöchel, Stephan A. Wacker, Nabila Bardine, Brigitte Korte, Cornelia Donow, Antony J. Durston
Publikováno v:
Developmental Dynamics. 238:755-765
Hox genes are key players in defining positional information along the main body axis of vertebrate embryos. In Xenopus laevis, Hoxc6 was the first homeobox gene isolated. It encodes two isoforms. We analyzed in detail their spatial and temporal expr
Publikováno v:
Journal of Biological Chemistry. 283:34168-34177
The balance between differentiation signals and signals maintaining the undifferentiated state of embryonic cells ensures proper formation of germ layers. The nodal/activin pathway represents one of the major signaling chains responsible for the diff
Publikováno v:
The EMBO Journal. 26:2942-2954
VegT and beta-Catenin are key players in the hierarchy of factors that are required for induction and patterning of mesendoderm in Xenopus embryogenesis. By descending the genetic cascades, cells lose their pluripotent status and are determined to di
Publikováno v:
Mechanisms of Development. 123:614-625
Three POU factors of subclass V, Oct-25, Oct-60 and Oct-91 are expressed in Xenopus oocytes and early embryos. We here demonstrate that vegetal overexpression of Oct-25, Oct-60, Oct-91 or mammalian Oct-3/4 suppresses mesendoderm formation in Xenopus
Autor:
Maximilian Schuff, Walter Knöchel, Antje Rossner, Cornelia Donow, Stephan A. Wacker, Susanne Gessert
Publikováno v:
Developmental Dynamics. 236:226-239
A functional knockdown of FoxN3, a member of subclass N of fork head/winged helix transcription factors in Xenopus laevis, leads to an abnormal formation of the jaw cartilage, absence or malformation of distinct cranial nerves, and reduced size of th
Autor:
Barbara S. Pohl, Walter Knöchel
Publikováno v:
Gene. 344:21-32
Transcription factors of the Fox (fork head box) family have been found in all metazoan organisms. They are characterised by an evolutionary conserved DNA-binding domain of winged helix structure. In the South African clawed frog, Xenopus laevis, mor