Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Walter K, Mowel"'
Autor:
Michaël F. Michieletto, John J. Tello-Cajiao, Walter K. Mowel, Aditi Chandra, Sora Yoon, Leonel Joannas, Megan L. Clark, Monica T. Jimenez, Jasmine M. Wright, Patrick Lundgren, Adam Williams, Christoph A. Thaiss, Golnaz Vahedi, Jorge Henao-Mejia
Publikováno v:
Nat Immunol
Innate lymphoid cells (ILCs) are well-characterized immune cells that play key roles in host defense and tissue homeostasis. Yet, how the three-dimensional (3D) genome organization underlies the development and functions of ILCs is unknown. Herein, w
Autor:
Autumn G. York, Mathias H. Skadow, Rihao Qu, Joonseok Oh, Walter K. Mowel, J. Richard Brewer, Eleanna Kaffe, Kevin J. Williams, Yuval Kluger, Jason M. Crawford, Stephen T. Smale, Steven J. Bensinger, Richard A. Flavell
Publikováno v:
bioRxiv
Unchecked chronic inflammation is the underlying cause of many diseases, ranging from inflammatory bowel disease to obesity and neurodegeneration. Given the deleterious nature of unregulated inflammation, it is not surprising that cells have acquired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc43508e567e65fcce448ea1f93699a
https://doi.org/10.1101/2023.05.07.539780
https://doi.org/10.1101/2023.05.07.539780
Autor:
Kristin A. Gabor, Michelle F. Goody, Walter K. Mowel, Meghan E. Breitbach, Remi L. Gratacap, P. Eckhard Witten, Carol H. Kim
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 11, Pp 1227-1237 (2014)
Seasonal influenza virus infections cause annual epidemics and sporadic pandemics. These present a global health concern, resulting in substantial morbidity, mortality and economic burdens. Prevention and treatment of influenza illness is difficult d
Externí odkaz:
https://doaj.org/article/56cf02718d4d44ada5d6e00169d42fac
Autor:
Vanessa D. Neal, Jasmine M. Wright, E. John Wherry, Fany Iseka, Megan L. Clark, Adam Williams, Sean P. Spencer, Jonathan J. Kotzin, Montserrat C. Anguera, Walter K. Mowel, Mohammed-Alkhatim Ali, Tanner F. Robertson, Camille M. Syrett, Mohamed S. Abdel-Hakeem, Megha G. Basavappa, Jorge Henao-Mejia, Leonel Joannas
Publikováno v:
Proceedings of the National Academy of Sciences. 116:11916-11925
The transcriptional programs that regulate CD8 T-cell differentiation and function in the context of viral infections or tumor immune surveillance have been extensively studied; yet how long noncoding RNAs (lncRNAs) and the loci that transcribe them
Autor:
Jonathan J, Kotzin, Fany, Iseka, Jasmine, Wright, Megha G, Basavappa, Megan L, Clark, Mohammed-Alkhatim, Ali, Mohamed S, Abdel-Hakeem, Tanner F, Robertson, Walter K, Mowel, Leonel, Joannas, Vanessa D, Neal, Sean P, Spencer, Camille M, Syrett, Montserrat C, Anguera, Adam, Williams, E John, Wherry, Jorge, Henao-Mejia
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(24)
The transcriptional programs that regulate CD8 T-cell differentiation and function in the context of viral infections or tumor immune surveillance have been extensively studied; yet how long noncoding RNAs (lncRNAs) and the loci that transcribe them
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs
Autor:
Sarah E. Henrickson, Maayan Levy, Monica T. Jimenez, Sam J. McCright, Sean P. Spencer, Megan L. Clark, Christoph A. Thaiss, Sasikanth Manne, Anthony Virtue, Stephen H. Eisennagel, Walter K. Mowel, Jonathan J. Kotzin, Megha G. Basavappa, Jorge Henao-Mejia, Adam Williams, E. John Wherry, Leonel Joannas, Jasmine M. Wright, Eran Elinav
Publikováno v:
Science Translational Medicine
The gut microbiota is a key environmental determinant of mammalian metabolism. Regulation of white adipose tissue (WAT) by the gut microbiota is a process critical to maintaining metabolic fitness, and gut dysbiosis can contribute to the development
Publikováno v:
Trends in immunology. 39(1)
The immune system is comprised of diverse cell types that coordinate responses to infection and maintain tissue homeostasis. In each of these cells, extracellular cues determine highly specific epigenetic landscapes and transcriptional profiles to pr
Publikováno v:
Science. 358:993-994
Viruses are parasitic entities that lack the basic metabolic machinery required to provide the energy and biosynthetic building blocks needed for their replication. To overcome this obstacle, viruses hijack the cellular metabolic machinery of their h
Autor:
Jonathan J Kotzin, Sean P Spencer, Sam J McCright, Dinesh B. Uthaya Kumar, Walter K Mowel, Michelle Makiya, Amy D. Klion, Adam Williams, Richard A Flavell, Jorge Henao-Mejia
Publikováno v:
The Journal of Immunology. 196:202.28-202.28
Neutrophils, eosinophils and “classical” monocytes collectively account for ~70% of blood leukocytes and are among the shortest-lived cells in the body. Precise regulation of the short lifespan of these myeloid cells is critical to maintain effec
Autor:
Anthony Virtue, Loyal A. Goff, Adam Williams, Gretchen Harms Pritchard, Margaret C. Dunagin, John L. Rinn, En Jun Yang, Cynthia Hughes, Taku Kambayashi, Sam J. McCright, Henrique Veiga-Fernandes, Richard A. Flavell, Alexandra DeLaney, Magalie A. Collet, Igor E. Brodsky, Sean P. Spencer, Asli Uyar, Jorge Henao-Mejia, E. John Wherry, John J. O'Shea, Judith Stein, Jonathan J. Kotzin, Arjun Raj, Alejandro V. Villarino, Makoto Kurachi, Diogo Fonseca-Pereira, Xin Chen, Walter K. Mowel
Publikováno v:
Immunity
© 2017 Elsevier Inc.
Commitment to the innate lymphoid cell (ILC) lineage is determined by Id2, a transcriptional regulator that antagonizes T and B cell-specific gene expression programs. Yet how Id2 expression is regulated in each ILC subset
Commitment to the innate lymphoid cell (ILC) lineage is determined by Id2, a transcriptional regulator that antagonizes T and B cell-specific gene expression programs. Yet how Id2 expression is regulated in each ILC subset