Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Walter J. Muir"'
Autor:
René A W Frank, Allan F McRae, Andrew J Pocklington, Louie N van de Lagemaat, Pau Navarro, Mike D R Croning, Noboru H Komiyama, Sophie J Bradley, R A John Challiss, J Douglas Armstrong, Robert D Finn, Mary P Malloy, Alan W MacLean, Sarah E Harris, John M Starr, Sanjeev S Bhaskar, Eleanor K Howard, Sarah E Hunt, Alison J Coffey, Venkatesh Ranganath, Panos Deloukas, Jane Rogers, Walter J Muir, Ian J Deary, Douglas H Blackwood, Peter M Visscher, Seth G N Grant
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19011 (2011)
Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role of glutamate receptors and their interacting scaffold proteins, the exons of ten glutamater
Externí odkaz:
https://doaj.org/article/fc8f88c9f5314babada323faa5b3d351
Autor:
Dinesh C. Soares, Shaun Mackie, Sheila Christie, Elizabeth A. Blackburn, Gareth James Briggs, David J. Porteous, Jennifer E. Eykelenboom, Walter J. Muir, Nicholas J. Bradshaw, Elise L.V. Malavasi, M. P. Malloy, J. Kirsty Millar, Fumiaki Ogawa, Janice Bramham, Martin A. Wear, Paraskevi Makedonopoulou, Andrew M. McIntosh, Douglas Blackwood
Publikováno v:
Human Molecular Genetics
Eykelenboom, J E, Briggs, G J, Bradshaw, N J, Soares, D C, Ogawa, F, Christie, S, Malavasi, E L V, Makedonopoulou, P, Mackie, S, Malloy, M P, Wear, M A, Blackburn, E A, Bramham, J, Mcintosh, A M, Blackwood, D H, Muir, W J, Porteous, D J & Millar, J K 2012, ' A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins ', Human Molecular Genetics, vol. 21, no. 15, pp. 3374-3386 . https://doi.org/10.1093/hmg/dds169
Eykelenboom, J E, Briggs, G J, Bradshaw, N J, Soares, D C, Ogawa, F, Christie, S, Malavasi, E L V, Makedonopoulou, P, Mackie, S, Malloy, M P, Wear, M A, Blackburn, E A, Bramham, J, Mcintosh, A M, Blackwood, D H, Muir, W J, Porteous, D J & Millar, J K 2012, ' A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins ', Human Molecular Genetics, vol. 21, no. 15, pp. 3374-3386 . https://doi.org/10.1093/hmg/dds169
Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression.
Autor:
Douglas Blackwood, Benjamin S. Pickard, David J. Porteous, Walter J. Muir, Li Sha, Robert R. Kitchen
Publikováno v:
Acta Neuropsychiatrica. 24:16-25
Objective:Deficits in adult and embryonic neurogenesis have been linked with neurological and psychiatric disorders, so it is important to understand the molecular mechanisms underlying this process. SOX11 is a transcription factor known to play a cr
Publikováno v:
Journal of Psychopathology and Behavioral Assessment. 33:246-253
Schizophrenia and intellectual disability (ID) co-occur three times more than would be expected by chance. This has led to speculation that a particular form of schizophrenia may give rise to both the symptoms of schizophrenia and the intellectual im
Autor:
Yoshimitsu Fukushima, Douglas Blackwood, Akira Sawa, Kumiko Fujii, Yuji Ozeki, Shin Ichi Kano, Benjamin S. Pickard, Daniel Q. Sun, Walter J. Muir, Mariela Zeledon, M. P. Malloy, Kenji Hashimoto, Yukihiko Shirayama, Keiko Wakui, Hiroshi Kunugi
Publikováno v:
Ozeki, Y, Pickard, B S, Kano, S, Malloy, M P, Zeledon, M, Sun, D Q, Fujii, K, Wakui, K, Shirayama, Y, Fukushima, Y, Kunugi, H, Hashimoto, K, Muir, W J, Blackwood, D H & Sawa, A 2011, ' A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: Altered L-serine level associated with disruption of PSAT1 gene expression ', Neuroscience Research, vol. 69, no. 2, pp. 154-160 . https://doi.org/10.1016/j.neures.2010.10.003
L-Serine is required for the synthesis of glycine and D-serine, both of which are NMDA receptor coagonists. Although roles for D-serine and glycine have been suggested in schizophrenia, little is known about the role of the L-serine synthesizing casc
Publikováno v:
Journal of Applied Research in Intellectual Disabilities. 24:74-85
Background Little is known about the menopause in women with intellectual disabilities (ID) save that its onset is earlier than in the general population, and earlier still in women with Down’s syndrome (DS). This study directly explored menopausal
Autor:
D StClair, Marcella Rietschel, Rosie M. Walker, Markus M. Nöthen, Kevin A. McGhee, Andrea Christoforou, David J. Porteous, Walter J. Muir, Kathryn L. Evans, Thomas W. Mühleisen, Pippa A. Thomson, Sven Cichon, Douglas Blackwood, Omer Jilani, Alan Maclean, Jana Strohmaier, S. W. Morris, Vanessa Nieratschker
Publikováno v:
Walker, R, Christoforou, A, Thomson, P, McGhee, K, Maclean, A, Muhleisen, T W, Strohmaier, J, Nieratschker, V, Nothen, M M, Rietschel, M, Cichon, S, Morris, S W, Jilani, O, Stclair, D, Blackwood, D, Muir, W, Porteous, D J & Evans, K L 2010, ' Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder ', Neuroscience Letters, vol. 478, no. 1, pp. 9-13 . https://doi.org/10.1016/j.neulet.2010.04.056
Schizophrenia (SCZ) and bipolar disorder (BPD) are severe heritable psychiatric disorders involving a complex genetic aetiology. Neuregulin 1 (NRG1) is a leading candidate gene for SCZ, and has recently been implicated in BPD. We previously reported
Publikováno v:
Journal of Policy and Practice in Intellectual Disabilities. 7:42-48
Overall life expectancy for women with intellectual disabilities (ID) is now significantly extended, and many will live long enough to experience menopause. Little is known about how carers support women with ID through this important stage in their
Autor:
John M. Starr, David J. Porteous, Benjamin S. Pickard, Ronald E. Cannon, David St Clair, Alison Condie, Helen M. Knight, Margaret Van Beck, Angela White, Peter M. Visscher, Donald J. MacIntyre, Kevin A. McGhee, Alan Maclean, Walter J. Muir, Allan F. McRae, William Hawkins, Douglas Blackwood, M. P. Malloy, Ian J. Deary, Dinesh C. Soares
Publikováno v:
The American Journal of Human Genetics. 85:833-846
Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of approximately 80% indicating a substantial genetic component. Population genetics and genome-wide association studies suggest an
Autor:
Pamela Sklar, Paul Lichtenstein, Carlos Ferreira, Derek W. Morris, Douglas M. Ruderfer, Nigel Williams, Lyudmila Georgieva, Alan W Maclean, Emma M. Quinn, Srinivasa Thirumalai, Jacob Lawrence, Peter M. Visscher, Andrew McQuillin, António Macedo, Christina M. Hultman, Elaine Kenny, Kevin A. McGhee, George Kirov, Emma Flordal Thelander, Ayman H. Fanous, Walter J. Muir, Stacey Gabriel, Michael Conlon O'Donovan, Finny G Kuruvilla, Aiden Corvin, Edward M. Scolnick, Colm O'Dushlaine, Khalid Choudhury, Patrick Sullivan, Frank A. Middleton, Kimberly Chambert, Nicholas Walker, Christopher P. Morley, Patrick F. Sullivan, Michael Gill, Célia Barreto Carvalho, Manuel A. R. Ferreira, Susmita Datta, Robert Krasucki, M. Helena Azevedo, Soh Leh Kuan, Jennifer L. Moran, Stuart MacGregor, Draga Toncheva, P. Malloy, Douglas Blackwood, Shaun Purcell, Jonathan Pimm, Michael John Owen, Peter Holmans, David V. Conti, Gillian Fraser, Vinay Puri, Naomi R. Wray, Andrew Kirby, Margaret Van Beck, Digby Quested, Kristin G. Ardlie, Ben S. Pickard, Caroline Crombie, Vihra Milanova, Carlos N. Pato, Nicholas John Craddock, Jennifer Stone, Nadine Norton, Mark J. Daly, James A. Knowles, Hugh Gurling, David St Clair, Hywel Williams, Michele T. Pato, Helena Medeiros, Nicholas Bass, Ivan Nikolov
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a genome-wide association study of 3,322 European in