Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Walter J. Kozumbo"'
Autor:
Rehana K. Leak, Edward J. Calabrese, Walter J. Kozumbo, Jeffrey M. Gidday, Thomas E. Johnson, James R. Mitchell, C. Keith Ozaki, Reinhard Wetzker, Aalt Bast, Regina G. Belz, Hans E. Bøtker, Sebastian Koch, Mark P. Mattson, Roger P. Simon, Randy L. Jirtle, Melvin E. Andersen
Publikováno v:
Dose-Response, Vol 16 (2018)
Human performance, endurance, and resilience have biological limits that are genetically and epigenetically predetermined but perhaps not yet optimized. There are few systematic, rigorous studies on how to raise these limits and reach the true maxima
Externí odkaz:
https://doaj.org/article/3eb871b58f0547168e8f9fcf6a6ec730
Autor:
James Giordano, Marom Bikson, Emily S. Kappenman, Vincent P. Clark, H. Branch Coslett, Michael R. Hamblin, Roy Hamilton, Ryan Jankord, Walter J. Kozumbo, R. Andrew McKinley, Michael A. Nitsche, J. Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
Publikováno v:
Dose-Response, Vol 15 (2017)
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current
Externí odkaz:
https://doaj.org/article/4c11136fbc784df6aa426931d4e69b7e
Publikováno v:
Human & Experimental Toxicology. 38:888-898
During the early part of the past century, hundreds of clinical studies involving more than 37,000 patients were conducted that showed radiotherapy (RT) to be a successful and safe alternative to drug therapy for the treatment of many diverse inflamm
Autor:
Edward J. Stanek, Edward J. Calabrese, Evgenios Agathokleous, Denise A. Leonard, Walter J. Kozumbo
Publikováno v:
Environmental Research. 170:337-343
An ever-expanding hormetic database (HDB) was used to demonstrate that the median maximal hormetic stimulatory response (MHSR) of biphasic dose-response relationships increases in value with an increase in the number of stimulatory doses/concentratio
Autor:
Edward J. Calabrese, Pedro C. Lara, Walter J. Kozumbo, Rachna Kapoor, Gaurav Dhawan, James Giordano
Publikováno v:
Radiotherapy and Oncology
Novel mechanistic insights are discussed herein that link a single, nontoxic, low-dose radiotherapy (LDRT) treatment (0.5-1.0 Gy) to (1) beneficial subcellular effects mediated by the activation of nuclear factor erythroid 2-related transcription fac
Autor:
Walter J. Kozumbo, Edward J. Calabrese
Publikováno v:
Pharmacological research. 163
In numerous experimental models, sulforaphane (SFN) is shown herein to induce hormetic dose responses that are not only common but display endpoints of biomedical and clinical relevance. These hormetic responses are mediated via the activation of nuc
Autor:
Suresh I. S. Rattan, Walter J. Kozumbo, Rachna Kapoor, Evgenios Agathokleous, Edward J. Calabrese
Publikováno v:
Calabrese, E J, Agathokleous, E, Kapoor, R, Kozumbo, W J & Rattan, S I S 2019, ' Re-analysis of herbal extracts data reveals that inflammatory processes are mediated by hormetic mechanisms ', Chemico-Biological Interactions, vol. 314, 108844 . https://doi.org/10.1016/j.cbi.2019.108844
Calabrese, E, Agathokleous, E, Kapoor, R, Kozumbo, W J & Rattan, S 2019, ' Re-analysis of herbal extracts data reveals that inflammatory processes are mediated by hormetic mechanisms ', Chemico-Biological Interactions, vol. 314 .
Calabrese, E, Agathokleous, E, Kapoor, R, Kozumbo, W J & Rattan, S 2019, ' Re-analysis of herbal extracts data reveals that inflammatory processes are mediated by hormetic mechanisms ', Chemico-Biological Interactions, vol. 314 .
Using data from Schink et al. (2018), a large number of herbal extracts were assessed for their capacity to inducepro- and anti-inflammatory effects based on TLR4 expression normalized for cell viability in two immune cellmodels (i.e., HeLa-TLR4 tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ce4d2e995b5fa1ca2979612972196d
https://pure.au.dk/portal/da/publications/reanalysis-of-herbal-extracts-data-reveals-that-inflammatory-processes-are-mediated-by-hormetic-mechanisms(6c066e5a-27eb-4168-9be3-ddf6483872c4).html
https://pure.au.dk/portal/da/publications/reanalysis-of-herbal-extracts-data-reveals-that-inflammatory-processes-are-mediated-by-hormetic-mechanisms(6c066e5a-27eb-4168-9be3-ddf6483872c4).html
Autor:
Gaurav Dhawan, Rachna Kapoor, Walter J. Kozumbo, Vittorio Calabrese, Evgenios Agathokleous, Edward J. Calabrese
Publikováno v:
Ageing Research Reviews. 71:101418
The present paper demonstrates that metformin (MF) induced a broad spectrum of hormetic biphasic dose responses in a wide range of experimental studies, affecting multiple organ systems, cell types, and endpoints enhancing resilience to chemical stre
Autor:
Walter J. Kozumbo, Edward J. Calabrese
Publikováno v:
Pharmacological Research. 167:105526
A generalized mechanism for hormetic dose responses is proposed that is based on the redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of endogenous anti-oxidant and anti-inflammatory adaptive responses. N
Publikováno v:
Chemico-Biological Interactions. 341:109464
Current regulatory cancer risk assessment principles and practices assume a linear dose-response relationship-the linear no-threshold (LNT) model-that theoretically estimates cancer risks occurring following low doses of carcinogens by linearly extra