Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Walter J. Kleinschmidt"'
Autor:
Edward B. Murphy, Richard M. Schultz, Richard J. Douthart, Frank W. Beasley, Walter J. Kleinschmidt
Publikováno v:
Journal of Interferon Research. 2:493-499
Double-stranded RNA (dsRNA) molecules, generally effective inducers of interferon (IFN), have a weak potency in man apparently because of the presence of a serum RNAase which quickly inactivates extracellular dsRNA. We have discovered that tobramycin
Autor:
Walter J. Kleinschmidt
Publikováno v:
Annals of the New York Academy of Sciences. 173:547-556
Publikováno v:
Analytical Biochemistry. 55:601-608
Two small RNA viruses, mycophage PS-1, and bacteriophage φ6 were concentrated and purified by the sequential use of continuous flow zonal centrifugation, high speed continuous flow sedimentation, and combined rate zonal centrifugation and isopycnic
Publikováno v:
Nature. 305(5931)
We have previously suggested that two lymphokine activities-macrophage activating factor (MAF) and gamma interferon (IFN-gamma)-are mediated by the same molecule. Striking similarities were noted in their cellular biosynthesis, rate of inactivation w
Publikováno v:
Journal of interferon research. 2(2)
Murine spleen lymphoid cells treated with insoluble (Sepharose bound) concanavalin A elaborate Gamma (immune) interferon (IFN-gamma) and macrophage activation factor (MAF) into the culture medium. Similarly, MAF is produced by T cells with other IFN-
Publikováno v:
Nature. 220(5163)
PREPARATIONS of statolon derived from fermentation broths of Penicillium stoloniferum are capable of inducing interferon and contain particles with viral morphology1–2. Interferon inducing activity is separable into a small molecular and a particul
Autor:
Walter J. Kleinschmidt
Publikováno v:
Perspectives in biology and medicine. 17(3)
Publikováno v:
Nature. 228(5266)
Autor:
Walter J. Kleinschmidt
Publikováno v:
Annual review of biochemistry. 41(10)
Publikováno v:
Proceedings, annual meeting, Electron Microscopy Society of America. 27:424-425
The extract from Penicillum stoliniferum, known as statolon, has been purified by density gradient centrifugation. These centrifuge fractions contained virus particles that are an interferon inducer in mice or in tissue culture. Highly purified prepa