Výsledky vyhledávání - "Walter J. Burgess"

Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents

Publikováno v: Antimicrobial Agents and Chemotherapy. 46:3118-3124

Bacterial enoyl-acyl carrier protein (ACP) reductase (FabI) catalyzes the final step in each elongation cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. High-throughput screening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997a68e3d46cb5b0dd9196003827969e
https://doi.org/10.1128/aac.46.10.3118-3124.2002

Zobrazit plný text záznamu

Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI)

Autor: William F. Huffman, Paul M. Keller, Valerie Berry, Walter E. DeWolf, William H. Miller, Catherine C.K. Yuan, Mark A. Seefeld, Stephen Rittenhouse, Brian J. Polizzi, Stewart C. Pearson, Cheryl A. Janson, Dirk A. Heerding, Walter J. Burgess, Martha S. Head, Terrance D. Moore, Kenneth A. Newlander, Xiayang Qiu, Irene N. Uzinskas, David J. Payne

Publikováno v: Journal of Medicinal Chemistry. 45:3246-3256

Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. Our eff...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac5be10717eef2aed6ee5bf83df2f1ef
https://doi.org/10.1021/jm020050+

Zobrazit plný text záznamu

Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents

Autor: Kenneth A. Newlander, Kalindi Vaidya, William F. Huffman, William H. Miller, Paul M. Keller, Walter E. DeWolf, Terrance D. Moore, Xiayang Qiu, Courtney Slater-Radosti, Cheryl A. Janson, Mark A. Seefeld, Martin G. Smyth, David J. Payne, Deborah Dee Jaworski, Andrew P. Fosberry, Walter J. Burgess, Stephen Rittenhouse

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:2241-2244

An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7905df83251b089a15bd4bfe57170a3f
https://doi.org/10.1016/s0960-894x(01)00405-x

Zobrazit plný text záznamu

Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK

Publikováno v: Journal of medicinal chemistry. 46(9)

Bacterial enoyl-ACP reductase (FabI) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis and is an attractive target for the development of novel antibacterial agents. Previously we reported the development of FabI inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ee8292abc59749735aeddbd0d1ed93
https://pubmed.ncbi.nlm.nih.gov/12699381

Zobrazit plný text záznamu

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

Autor: William H, Miller, Mark A, Seefeld, Kenneth A, Newlander, Irene N, Uzinskas, Walter J, Burgess, Dirk A, Heerding, Catherine C K, Yuan, Martha S, Head, David J, Payne, Stephen F, Rittenhouse, Terrance D, Moore, Stewart C, Pearson, Valerie, Berry, Walter E, DeWolf, Paul M, Keller, Brian J, Polizzi, Xiayang, Qiu, Cheryl A, Janson, William F, Huffman

Publikováno v: Journal of medicinal chemistry. 45(15)

Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. Our efforts to identify potent, selective FabI inhibitors be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88457e027bb10a51dc01df9d68bcf47b
https://pubmed.ncbi.nlm.nih.gov/12109908

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání