Výsledky vyhledávání - "Walter J Moretto"

Akademický článek

Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease.

Autor: Brinda Emu, Walter J Moretto, Rebecca Hoh, Melissa Krone, Jeffrey N Martin, Douglas F Nixon, Steven G Deeks, Joseph M McCune

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85613 (2014)

The ability to reconstitute a normal immune system with antiretroviral therapy in the setting of HIV infection remains uncertain. This study aimed to characterize quantitative and qualitative aspects of various T cell subpopulations that do not impro

Externí odkaz: https://doaj.org/article/5be25b4023fd48e089b4316c51a28abe

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Phenotypic, Functional, and Kinetic Parameters Associated with Apparent T-Cell Control of Human Immunodeficiency Virus Replication in Individuals with and without Antiretroviral Treatment

Autor: Elizabeth Sinclair, Priscilla Y. Hsue, Steven G. Deeks, Brinda Emu, Douglas F. Nixon, Walter J. Moretto, David Favre, Rebecca Hoh, Joseph M. McCune, Jeffrey N. Martin

Publikováno v: Journal of Virology. 79:14169-14178

The human immunodeficiency virus (HIV)-mediated immune response may be beneficial or harmful, depending on the balance between expansion of HIV-specific T cells and the level of generalized immune activation. The current study utilizes multicolor cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d200d9ebabfb9fb2b292e6832b7380
https://doi.org/10.1128/jvi.79.22.14169-14178.2005

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R5 Human Immunodeficiency Virus Type 1 (HIV-1) Replicates More Efficiently in Primary CD4 + T-Cell Cultures Than X4 HIV-1

Autor: Walter J. Moretto, Duncan A. Meiklejohn, Douglas F. Nixon, Jonas J. Heymann, Becky Schweighardt, Ann-Marie Roy, Edward J. Grace

Publikováno v: Journal of Virology. 78:9164-9173

In this report, we present evidence that R5 human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in primary CD4 + T cells than X4 HIV-1. By comparing CD3/CD28-costimulated CD4 + T-cell cultures infected by several X4 and R5 HIV-1 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b809d72664be94451a1c6d38259da9
https://doi.org/10.1128/jvi.78.17.9164-9173.2004

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Highly Effective Control of an AIDS Virus Challenge in Macaques by Using Vesicular Stomatitis Virus and Modified Vaccinia Virus Ankara Vaccine Vectors in a Single-Boost Protocol

Autor: John K. Rose, Nina F. Rose, Bernard Moss, Megan Mefford, David C. Montefiori, Patricia L. Earl, Elizabeth Ramsburg, Preston A. Marx, Douglas F. Nixon, Walter J. Moretto

Publikováno v: Journal of Virology. 78:3930-3940

Previous studies have shown that vaccination and boosting of rhesus macaques with attenuated vesicular stomatitis virus (VSV) vectors encoding Env and Gag proteins of simian immunodeficiency virus-human immunodeficiency virus (SHIV) hybrid viruses pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ea8c1c1d37e14b2f7e8b0baeaca944
https://doi.org/10.1128/jvi.78.8.3930-3940.2004

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Human CD4+CD25+Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

Autor: Jakob Michaëlsson, Walter J. Moretto, Douglas F. Nixon, Einar Martin Aandahl, Frederick Hecht

Publikováno v: Journal of Virology. 78:2454-2459

Regulatory T (TR) cells maintain tolerance to self-antigens and control immune responses to alloantigens after organ transplantation. Here, we show that CD4+CD25+human TRcells suppress virus-specific T-cell responses. Depletion of TRcells from periph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e2b58802782ffb3fa80b80654999db
https://doi.org/10.1128/jvi.78.5.2454-2459.2004

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Boosting of SIV-Specific T Cell Responses in Rhesus Macaques That Resist Repeated Intravaginal Challenge with SIVmac251

Autor: Jennifer Hu, Preston A. Marx, David T. Wilkens, Douglas F. Nixon, Zimra R. Israel, Walter J. Moretto, Binhua Ling, Amara Luckay, Barbara L. Shacklett, Ronald S. Veazey

Publikováno v: AIDS Research and Human Retroviruses. 18:1081-1088

Despite repeated high-risk exposure to infectious HIV-1, some individuals remain HIV-1 seronegative and apparently uninfected. The use of nonhuman primate model systems to study SIVmac transmission may help to elucidate the factors responsible for pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9576442541ecc6693d97dc6db6ffe27
https://doi.org/10.1089/08892220260235434

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Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease

Autor: Rebecca Hoh, Melissa R. Krone, Steven G. Deeks, Walter J. Moretto, Joseph M. McCune, Jeffrey N. Martin, Douglas F. Nixon, Brinda Emu

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85613 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46790e1f60715efc5ed1b6a0acf12193
http://europepmc.org/articles/PMC3897457?pdf=render

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Inhibition of Human Immunodeficiency Virus Type 1 gp120 Presentation to CD4 T Cells by Antibodies Specific for the CD4 Binding Domain of gp120

Autor: Miroslaw K. Gorny, Walter J. Moretto, Peter Chien, Michael Tuen, Philip J. Norris, Silvia Ratto-Kim, Douglas F. Nixon, Gareth Jones, Catarina E. Hioe, Susan Zolla-Pazner

Publikováno v: Journal of Virology. 75:10950-10957

Human immunodeficiency virus (HIV)-specific CD4 T-cell responses, particularly to the envelope glycoproteins of the virus, are weak or absent in most HIV-infected patients. Although these poor responses can be attributed simply to the destruction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b324dd06ba78153931c155ad4d9acb84
https://doi.org/10.1128/jvi.75.22.10950-10957.2001

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Direct Measurement of CD4+ and CD8+ T-Cell Responses to CMV in HIV-1-Infected Subjects

Autor: Mario Roederer, Joseph M. McCune, Sean M. Donahoe, Graham S. Ogg, Walter J. Moretto, Geraldine M. Gillespie, Krishna V. Komanduri, Douglas F. Nixon, D K Schmidt

Publikováno v: Virology. 279:459-470

Data from murine models of chronic viral infection suggest that CD4+ T-cell responses to viral pathogens are important in sustaining the number and/or function of CD8+ cytotoxic T-cell (CTL) effectors. In this study, we used cytokine flow cytometry (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3dff172eeb2ec5e54556e9f21b3151
https://doi.org/10.1006/viro.2000.0697

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Direct Measurement of CD8+ T Cell Responses in Macaques Infected with Simian Immunodeficiency Virus

Autor: Ruth I. Connor, Preston A. Marx, Douglas F. Nixon, Tomáš Hanke, Walter J. Moretto, Sean M. Donahoe, Karin J. Metzner, Rachel V. Samuel

Publikováno v: Virology. 272:347-356

The simian immunodeficiency virus (SIV) macaque model system has been used extensively to study AIDS pathogenesis and to test candidate vaccines for their ability to protect against homologous or heterologous challenge with pathogenic SIV or SHIV. Re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abea7f568b3d34c44a19d7347bb39820
https://doi.org/10.1006/viro.2000.0404

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