Zobrazeno 1 - 10
of 735
pro vyhledávání: '"Walter J Koch"'
Autor:
Michael A Augello, Lisa D Berman‐Booty, Richard Carr 3rd, Akihiro Yoshida, Jeffry L Dean, Matthew J Schiewer, Felix Y Feng, Scott A Tomlins, Erhe Gao, Walter J Koch, Jeffrey L Benovic, John Alan Diehl, Karen E Knudsen
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 5, Pp 628-647 (2015)
Abstract Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from
Externí odkaz:
https://doaj.org/article/c0a939ceeb9240749fd9c3c0d5d3e22e
Autor:
Philipp Schlegel, Julia Reinkober, Eric Meinhardt, Henrike Tscheschner, Erhe Gao, Sarah M Schumacher, Ancai Yuan, Johannes Backs, Patrick Most, Thomas Wieland, Walter J Koch, Hugo A Katus, Philip W Raake
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0182110 (2017)
The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various
Externí odkaz:
https://doaj.org/article/73aee9149d9c43f68bd8d68bdc460de0
Autor:
Darukeshwara Joladarashi, Charan Thej, Vandana Mallaredy, Ajit Magadum, Maria Cimini, Carolina Gonzalez, May Truongcao, Joseph T. Nigro, Manveen K. Sethi, Andrew A. Gibb, Cindy Benedict, Walter J. Koch, Raj Kishore
Publikováno v:
iScience, Vol 27, Iss 10, Pp 111021- (2024)
Summary: Mesenchymal stromal cells (MSC) are promising stem cell therapy for treating cardiovascular and other degenerative diseases. Diabetes affects the functional capability of MSC and impedes cell-based therapy. Despite numerous studies, the impa
Externí odkaz:
https://doaj.org/article/3a9a8135cbdf48ae9273925cf1080a09
Autor:
Yanqing Zhang, Jianli Zhao, Wayne Bond Lau, Li-Yuan Jiao, Baojiang Liu, Yuexing Yuan, Xiaoliang Wang, Erhe Gao, Walter J Koch, Xin-Liang Ma, Yajing Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e60227 (2013)
This study determines the roles of tumor necrosis factor-α (TNFα) and lymphotoxin-α (LTα) in post-myocardial infarction (post-MI) cardiac injury, and identifies the TNF receptor type responsible for TNFα- and LTα-mediated cardiac injury.Adult m
Externí odkaz:
https://doaj.org/article/983c7f95aa2642a287b9ca2331dbcb00
Autor:
Jessica I Gold, Jeffrey S Martini, Jonathan Hullmann, Erhe Gao, J Kurt Chuprun, Linda Lee, Douglas G Tilley, Joseph E Rabinowitz, Julie Bossuyt, Donald M Bers, Walter J Koch
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57324 (2013)
G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following ventricular pressure overload, GRK5, a primary cardiac GRK, facilitates maladaptive myocyte g
Externí odkaz:
https://doaj.org/article/f933052fcc7e42b0bf320c5f5af94e73
Autor:
Robert M Starke, Muhammad S Ali, Pascal M Jabbour, Stavropoula I Tjoumakaris, Fernando Gonzalez, David M Hasan, Robert H Rosenwasser, Gary K Owens, Walter J Koch, Aaron S Dumont
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71954 (2013)
The role of smooth muscle cell (SMC) phenotypic modulation in the cerebral circulation and pathogenesis of stroke has not been determined. Cigarette smoke is a major risk factor for atherosclerosis, but potential mechanisms are unclear, and its role
Externí odkaz:
https://doaj.org/article/ef8263b3d78c428d8015fcb407082ec2
Autor:
Qian Fan, Mai Chen, Lin Zuo, Xiying Shang, Maggie Z Huang, Michele Ciccarelli, Philip Raake, Henriette Brinks, Kurt J Chuprun, Gerald W Dorn, Walter J Koch, Erhe Gao
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66234 (2013)
Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction. Since GRK2 appears to also act as a pro-death kinase in m
Externí odkaz:
https://doaj.org/article/03dd335e8ad04b708df7e5863c44a96b
Autor:
Charles N. S. Allen, Sterling P. Arjona, Maryline Santerre, Claudio De Lucia, Walter J. Koch, Bassel E. Sawaya
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
A significant number of patients infected with HIV-1 suffer from HIV-associated neurocognitive disorders (HAND) such as spatial memory impairments and learning disabilities (SMI-LD). SMI-LD is also observed in patients using combination antiretrovira
Externí odkaz:
https://doaj.org/article/dfbeaea26f8246c5aba526fae7f2ee93
Autor:
Gizem Kayki-Mutlu, Walter J. Koch
Publikováno v:
Biochemical Society Transactions. 51:715-724
G protein-coupled receptors (GPCRs) are key modulators of cell signaling. Multiple GPCRs are present in the heart where they regulate cardiac homeostasis including processes such as myocyte contraction, heart rate and coronary blood flow. GPCRs are p
Autor:
Alessandro Cannavo, Seungho Jun, Giuseppe Rengo, Federica Marzano, Jacopo Agrimi, Daniela Liccardo, Andrea Elia, Gizem Keceli, Giovanna G. Altobelli, Lorenzo Marcucci, Aram Megighian, Erhe Gao, Ning Feng, Kai Kammers, Nicola Ferrara, Livio Finos, Walter J. Koch, Nazareno Paolocci
Publikováno v:
Circulation Research. 132:867-881
Background: Loss of brain-derived neurotrophic factor (BDNF)/TrkB (tropomyosin kinase receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic receptor stimulation enhances local BDNF expression. It is unclear if this