Zobrazeno 1 - 10
of 354
pro vyhledávání: '"Walter J Chazin"'
Publikováno v:
eLife, Vol 9 (2020)
Ubiquitination regulates many different cellular processes, including protein quality control, membrane trafficking, and stress responses. The diversity of ubiquitin functions in the cell is partly due to its ability to form chains with distinct link
Externí odkaz:
https://doaj.org/article/9ee6ebe9c5704e8283ef288fb9d2227b
Autor:
Stavros Maurakis, Kayla Keller, C Noel Maxwell, Kevin Pereira, Walter J Chazin, Alison K Criss, Cynthia Nau Cornelissen
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007937 (2019)
Neisseria gonorrhoeae causes the sexually-transmitted infection gonorrhea, a global disease that is difficult to treat and for which there is no vaccine. This pathogen employs an arsenal of conserved outer membrane proteins called TonB-dependent tran
Externí odkaz:
https://doaj.org/article/b1b917bcb94f40169f7ee52f9a8094ad
Autor:
Chang-He Shi, Carrie Rubel, Sarah E Soss, Rebekah Sanchez-Hodge, Shuo Zhang, Sabrina C Madrigal, Saranya Ravi, Holly McDonough, Richard C Page, Walter J Chazin, Cam Patterson, Cheng-Yuan Mao, Monte S Willis, Hai-Yang Luo, Yu-Sheng Li, Donte A Stevens, Mi-Bo Tang, Pan Du, Yao-He Wang, Zheng-Wei Hu, Yu-Ming Xu, Jonathan C Schisler
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007664 (2018)
CHIP (carboxyl terminus of heat shock 70-interacting protein) has long been recognized as an active member of the cellular protein quality control system given the ability of CHIP to function as both a co-chaperone and ubiquitin ligase. We discovered
Externí odkaz:
https://doaj.org/article/65933774acf445dba5e78330c3afc93f
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209345 (2018)
The regulatory subunit of human DNA primase has a C-terminal domain (p58C) that contains a [4Fe4S] cluster and binds DNA. Previous electrochemical analysis of a p58C construct revealed that its affinity for DNA is sensitive to the redox state of the
Externí odkaz:
https://doaj.org/article/bf0791f5764d4ffdb09af83fd22aaa7d
Autor:
Sora Lee, Jessica M Tumolo, Aaron C Ehlinger, Kristin K Jernigan, Susan J Qualls-Histed, Pi-Chiang Hsu, W Hayes McDonald, Walter J Chazin, Jason A MacGurn
Publikováno v:
eLife, Vol 6 (2017)
Despite its central role in protein degradation little is known about the molecular mechanisms that sense, maintain, and regulate steady state concentration of ubiquitin in the cell. Here, we describe a novel mechanism for regulation of ubiquitin hom
Externí odkaz:
https://doaj.org/article/c7cb9526e5f849d39368b53828016751
Autor:
Hoonsik Cho, Do-Won Jeong, Qian Liu, Won-Sik Yeo, Thomas Vogl, Eric P Skaar, Walter J Chazin, Taeok Bae
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005026 (2015)
Calprotectin, the most abundant cytoplasmic protein in neutrophils, suppresses the growth of Staphylococcus aureus by sequestering the nutrient metal ions Zn and Mn. Here we show that calprotectin can also enhance the activity of the SaeRS two compon
Externí odkaz:
https://doaj.org/article/349ff11bb06640ceb144321bf27eab97
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128240 (2015)
The E3 ubiquitin ligase CHIP is involved in protein triage, serving as a co-chaperone for refolding as well as catalyzing ubiquitination of substrates. CHIP functions with both the stress induced Hsp70 and constitutive Hsc70 chaperones, and also play
Externí odkaz:
https://doaj.org/article/5a1ffb0118824141be1a86d7cb90c4ed
Autor:
Boting Ning, Michael D Feldkamp, David Cortez, Walter J Chazin, Katherine L Friedman, Ellen Fanning
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116093 (2015)
Simian virus 40 (SV40) serves as an important model organism for studying eukaryotic DNA replication. Its helicase, Large T-antigen (Tag), is a multi-functional protein that interacts with multiple host proteins, including the ubiquitous ssDNA bindin
Externí odkaz:
https://doaj.org/article/6eff77af34da4f1a9baccc420dad22dc
Autor:
Jennifer A Gaddy, Jana N Radin, John T Loh, M Blanca Piazuelo, Thomas E Kehl-Fie, Alberto G Delgado, Florin T Ilca, Richard M Peek, Timothy L Cover, Walter J Chazin, Eric P Skaar, Holly M Scott Algood
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004450 (2014)
Transition metals are necessary for all forms of life including microorganisms, evidenced by the fact that 30% of all proteins are predicted to interact with a metal cofactor. Through a process termed nutritional immunity, the host actively sequester
Externí odkaz:
https://doaj.org/article/ac24f7971a53476f94e4cccfb96bf4d1
Autor:
Valeria M. Reyes Ruiz, Jeffrey A. Freiberg, Andy Weiss, Erin R. Green, Mary-Elizabeth Jobson, Emily Felton, Lindsey N. Shaw, Walter J. Chazin, Eric P. Skaar
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT The host protein calprotectin inhibits the growth of a variety of bacterial pathogens through metal sequestration in a process known as “nutritional immunity.” Staphylococcus aureus growth is inhibited by calprotectin in vitro, and calpr
Externí odkaz:
https://doaj.org/article/2dacbeddd25143109c4698d041ac5eb3