Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Walter J, May"'
Autor:
Paulina M. Getsy, Walter J. May, Alex P. Young, Santhosh M. Baby, Gregory A. Coffee, James N. Bates, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Our lab is investigating the efficacy profiles of tropine analogs against opioid-induced respiratory depression. The companion manuscript reports that the cell-permeant tropeine, tropine ester (Ibutropin), produces a rapid and sustained reversal of t
Externí odkaz:
https://doaj.org/article/206aecfd4bd54baca01b5da85e16ff77
Autor:
Santhosh M. Baby, Walter J. May, Paulina M. Getsy, Gregory A. Coffee, Tej Nakashe, James N. Bates, Alan Levine, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Fentanyl elicits profound disturbances in ventilatory control processes in humans and experimental animals. The traditional viewpoint with respect to fentanyl-induced respiratory depression is that once the effects on the frequency of breathing (Freq
Externí odkaz:
https://doaj.org/article/18e3f66e88b64ca59062ba0937b3b4e6
Autor:
Santhosh M. Baby, Walter J. May, Alex P. Young, Christopher G. Wilson, Paulina M. Getsy, Gregory A. Coffee, Tristan H.J. Lewis, Yee-Hee Hsieh, James N. Bates, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116081- (2024)
L-cysteine ethylester (L-CYSee) is a membrane-permeable analogue of L-cysteine with a variety of pharmacological effects. The purpose of this study was to determine the effects of L-CYSee on morphine-induced changes in ventilation, arterial-blood gas
Externí odkaz:
https://doaj.org/article/700e8d74e6a44a1294fa6ee737f3d673
Autor:
Paulina M. Getsy, Gregory A. Coffee, Walter J. May, Santhosh M. Baby, James N. Bates, Stephen J. Lewis
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 498 (2024)
The present study examined the hypothesis that changes in the oxidation–reduction state of thiol residues in functional proteins play a major role in the expression of the ventilatory responses in conscious rats that occur during a hypoxic–hyperc
Externí odkaz:
https://doaj.org/article/c8977dbe30884ca2a11ef14cb3934e50
Autor:
James M. Seckler, Paulina M. Getsy, Walter J. May, Benjamin Gaston, Santhosh M. Baby, Tristan H. J. Lewis, James N. Bates, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
We have provided indirect pharmacological evidence that hypoxia may trigger release of the S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), from primary carotid body glomus cells (PGCs) of rats that then activates chemosensory afferents of the carotid
Externí odkaz:
https://doaj.org/article/a0ec66bd442e4023aed4041f3f036733
Autor:
Paulina M. Getsy, Sripriya Sundararajan, Walter J. May, Graham C. von Schill, Dylan K. McLaughlin, Lisa A. Palmer, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract The roles of endothelial nitric oxide synthase (eNOS) in the ventilatory responses during and after a hypercapnic gas challenge (HCC, 5% CO2, 21% O2, 74% N2) were assessed in freely-moving female and male wild-type (WT) C57BL6 mice and eNOS
Externí odkaz:
https://doaj.org/article/83b2cc0829054a62817de19918ed5a05
Autor:
Tristan H.J. Lewis, Walter J. May, Alex P. Young, James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Rita M. Ryan, Yee-Hsee Hsieh, James M. Seckler, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113939- (2022)
This study demonstrates that intravenous infusion of the cell-penetrant thiol ester, L-cysteine ethyl ester (L-CYSee), to adult male Sprague-Dawley rats elicited (a) minor alterations in frequency of breathing, expiratory time, tidal volume, minute v
Externí odkaz:
https://doaj.org/article/e97d1f8b74384e33b9624693da14c584
Autor:
Paulina M. Getsy, Sripriya Sundararajan, Walter J. May, Graham C. von Schill, Dylan K. McLaughlin, Lisa A. Palmer, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Decreases in arterial blood oxygen stimulate increases in minute ventilation via activation of peripheral and central respiratory structures. This study evaluates the role of endothelial nitric oxide synthase (eNOS) in the expression of the
Externí odkaz:
https://doaj.org/article/aa8d9a37798f4dda8ad6274154755b44
Autor:
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, James N. Bates, Christopher R. Ellis, Michael G. Feasel, Christopher G. Wilson, Tristan H. J. Lewis, Benjamin Gaston, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
We are developing a series of thiolesters that produce an immediate and sustained reversal of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without diminishing the antinociceptive effects of these opioids. We repor
Externí odkaz:
https://doaj.org/article/58575678264d4a8ca9cc27c71351a745
Autor:
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, Tristan H.J. Lewis, James N. Bates, Yee-Hsee Hsieh, Benjamin Gaston, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113277- (2022)
There is an urgent need for development of drugs that are able to reverse the adverse effects of opioids on breathing and arterial blood-gas (ABG) chemistry while preserving opioid analgesia. The present study describes the effects of bolus injection
Externí odkaz:
https://doaj.org/article/6ff878c2816540d6af32fc989e5eb70a