Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Walter J, May"'
Autor:
Paulina M. Getsy, Walter J. May, Alex P. Young, Santhosh M. Baby, Gregory A. Coffee, James N. Bates, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Our lab is investigating the efficacy profiles of tropine analogs against opioid-induced respiratory depression. The companion manuscript reports that the cell-permeant tropeine, tropine ester (Ibutropin), produces a rapid and sustained reversal of t
Externí odkaz:
https://doaj.org/article/206aecfd4bd54baca01b5da85e16ff77
Autor:
Santhosh M. Baby, Walter J. May, Paulina M. Getsy, Gregory A. Coffee, Tej Nakashe, James N. Bates, Alan Levine, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Fentanyl elicits profound disturbances in ventilatory control processes in humans and experimental animals. The traditional viewpoint with respect to fentanyl-induced respiratory depression is that once the effects on the frequency of breathing (Freq
Externí odkaz:
https://doaj.org/article/18e3f66e88b64ca59062ba0937b3b4e6
Autor:
Paulina M. Getsy, Gregory A. Coffee, Walter J. May, Santhosh M. Baby, James N. Bates, Stephen J. Lewis
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 498 (2024)
The present study examined the hypothesis that changes in the oxidation–reduction state of thiol residues in functional proteins play a major role in the expression of the ventilatory responses in conscious rats that occur during a hypoxic–hyperc
Externí odkaz:
https://doaj.org/article/c8977dbe30884ca2a11ef14cb3934e50
Autor:
James M. Seckler, Paulina M. Getsy, Walter J. May, Benjamin Gaston, Santhosh M. Baby, Tristan H. J. Lewis, James N. Bates, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
We have provided indirect pharmacological evidence that hypoxia may trigger release of the S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), from primary carotid body glomus cells (PGCs) of rats that then activates chemosensory afferents of the carotid
Externí odkaz:
https://doaj.org/article/a0ec66bd442e4023aed4041f3f036733
Autor:
Paulina M. Getsy, Sripriya Sundararajan, Walter J. May, Graham C. von Schill, Dylan K. McLaughlin, Lisa A. Palmer, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract The roles of endothelial nitric oxide synthase (eNOS) in the ventilatory responses during and after a hypercapnic gas challenge (HCC, 5% CO2, 21% O2, 74% N2) were assessed in freely-moving female and male wild-type (WT) C57BL6 mice and eNOS
Externí odkaz:
https://doaj.org/article/83b2cc0829054a62817de19918ed5a05
Autor:
Paulina M. Getsy, Sripriya Sundararajan, Walter J. May, Graham C. von Schill, Dylan K. McLaughlin, Lisa A. Palmer, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Decreases in arterial blood oxygen stimulate increases in minute ventilation via activation of peripheral and central respiratory structures. This study evaluates the role of endothelial nitric oxide synthase (eNOS) in the expression of the
Externí odkaz:
https://doaj.org/article/aa8d9a37798f4dda8ad6274154755b44
Autor:
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, James N. Bates, Christopher R. Ellis, Michael G. Feasel, Christopher G. Wilson, Tristan H. J. Lewis, Benjamin Gaston, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
We are developing a series of thiolesters that produce an immediate and sustained reversal of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without diminishing the antinociceptive effects of these opioids. We repor
Externí odkaz:
https://doaj.org/article/58575678264d4a8ca9cc27c71351a745
Autor:
Benjamin Gaston, Santhosh M. Baby, Walter J. May, Alex P. Young, Alan Grossfield, James N. Bates, James M. Seckler, Christopher G. Wilson, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d-cystine dimethyl ester (d-cystine diME
Externí odkaz:
https://doaj.org/article/41ace98fd93a40d48fca5e4e1a53a813
Autor:
Michael W. Jenkins, Faiza Khalid, Santhosh M. Baby, Walter J. May, Alex P. Young, James N. Bates, Feixiong Cheng, James M. Seckler, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract There is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible, preserving the analgesic actions of the opioids. We report that L-glutathione ethyl
Externí odkaz:
https://doaj.org/article/e8f4803ec10a4a88badb5c1309e08a21
Autor:
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, Alex P. Young, Benjamin Gaston, Matthew R. Hodges, Hubert V. Forster, James N. Bates, Christopher G. Wilson, Tristan H. J. Lewis, Yee-Hee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cell-penetrant thiol esters including the disulfides, D-cystine diethyl ester and D-cystine dimethyl ester, and the monosulfide, L-glutathione ethyl ester, prevent and/or reverse the deleterious effects of opioids, such as morphine and fentanyl, on b
Externí odkaz:
https://doaj.org/article/498c8bb8e48f4686a17a66cbccf872fb