Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Walter Hunziker"'
Autor:
Kakkad Regha, Mayuri Bhargava, Abdurrahmaan Al-Mubaarak, Chou Chai, Bhav Harshad Parikh, Zengping Liu, Claudine See Wei Wong, Walter Hunziker, Kah Leong Lim, Xinyi Su
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Retinal pigment epithelial (RPE) cell dysfunction and death are characteristics of age-related macular degeneration. A promising therapeutic option is RPE cell transplantation. Development of clinical grade stem-cell derived RPE requires eff
Externí odkaz:
https://doaj.org/article/3bd7339aa071480992c9732da3df4a0f
Autor:
Jianliang Xu, P. Jaya Kausalya, Alicia Ghia Min Ong, Christine Meng Fan Goh, Safiah Mohamed Ali, Walter Hunziker
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract TJP2/ZO-2-inactivating mutations in humans cause progressive cholestatic liver disease. Liver-specific deletion of Tjp2 in the mouse (Tjp2 cKO mice) leads to mild progressive cholestasis without an overt degradation of the bile-blood barrier
Externí odkaz:
https://doaj.org/article/b4277ca64cfe4e9a9e8fd858109a861d
Autor:
Bhav Harshad Parikh, Zengping Liu, Paul Blakeley, Qianyu Lin, Malay Singh, Jun Yi Ong, Kim Han Ho, Joel Weijia Lai, Hanumakumar Bogireddi, Kim Chi Tran, Jason Y. C. Lim, Kun Xue, Abdurrahmaan Al-Mubaarak, Binxia Yang, Sowmiya R, Kakkad Regha, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Zhongxing Zhang, Anand D. Jeyasekharan, Veluchamy Amutha Barathi, Weimiao Yu, Kang Hao Cheong, Timothy A. Blenkinsop, Walter Hunziker, Gopal Lingam, Xian Jun Loh, Xinyi Su
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
One common cause of vision loss after retinal detachment surgery is retinal scarring. Here the authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppression of epithelial-mesenchymal transition and hyper-proliferation
Externí odkaz:
https://doaj.org/article/29658a3e9704480d80f0623a65432050
Autor:
Swathi Lingam, Zengping Liu, Binxia Yang, Wendy Wong, Bhav Harshad Parikh, Jun Yi Ong, Debbie Goh, Daniel Soo Lin Wong, Queenie Shu Woon Tan, Gavin S. W. Tan, Graham E. Holder, Kakkad Regha, Veluchamy Amutha Barathi, Walter Hunziker, Gopal Lingam, Xianmin Zeng, Xinyi Su
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Background Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following retinal photoreceptor pr
Externí odkaz:
https://doaj.org/article/ebb00a72f8324335bf6cabbb07433c97
Autor:
Yaochun Zhang, Liangjian Lu, Zhenhua Hu, Yu Dai, Nurul Jannah Binti Ahmad, Jun Li Ng, Chang Yien Chan, Md. Zakir Hossain, Alwin Hwai Liang Loh, Jerrold M. Ward, Puay Hoon Tan, Sonia Davila, Vikrant Kumar, Walter Hunziker, Haishu Lin, Hui Kim Yap, Kar Hui Ng
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 6, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/c110950dde334c4596491e14d171efd7
Autor:
Déborah Neyrinck-Leglantier, Julien Lesage, Silvia Blacher, Arnaud Bonnomet, Walter Hunziker, Agnès Noël, Valérian Dormoy, Béatrice Nawrocki-Raby, Christine Gilles, Myriam Polette
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of sev
Externí odkaz:
https://doaj.org/article/9d1943e2c9f4411984740c92b60c8388
Autor:
Benedict Tan, Suat Peng, Siti Maryam J.M. Yatim, Jayantha Gunaratne, Walter Hunziker, Alexander Ludwig
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100074- (2020)
Summary: The peroxidase APEX2 has been used widely for proximity biotinylation and subsequent proteomics analyses. However, the poor membrane permeability of the biotin phenol substrate and the inhibitory effect of peroxide on the enzyme’s activity
Externí odkaz:
https://doaj.org/article/01769cb3ed164cdc9adabfe0c6968840
Autor:
Hwei Wuen Chan, Binxia Yang, Wendy Wong, Paul Blakeley, Ivan Seah, Queenie Shu Woon Tan, Haofei Wang, Mayuri Bhargava, Hazel Anne Lin, Charmaine HC Chai, Erlangga Ariadarma Mangunkusumo, Naing Thet, Yew Sen Yuen, Raman Sethi, Si Wang, Walter Hunziker, Gopal Lingam, Xinyi Su
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 9, p 2920 (2020)
(1) Background: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an established treatment for center-involving diabetic macular edema (ci-DME). However, the clinical response is heterogeneous. This study investigated miRNAs as a bi
Externí odkaz:
https://doaj.org/article/e8faec8b90f24ab3b0cd3c89684e593a
Autor:
Fei Yao, Jaya P. Kausalya, Yee Yen Sia, Audrey S.M. Teo, Wah Heng Lee, Alicia G.M. Ong, Zhenshui Zhang, Joanna H.J. Tan, Guoliang Li, Denis Bertrand, Xingliang Liu, Huay Mei Poh, Peiyong Guan, Feng Zhu, Thushangi Nadeera Pathiraja, Pramila N. Ariyaratne, Jaideepraj Rao, Xing Yi Woo, Shaojiang Cai, Fabianus H. Mulawadi, Wan Ting Poh, Lavanya Veeravalli, Chee Seng Chan, Seong Soo Lim, See Ting Leong, Say Chuan Neo, Poh Sum D. Choi, Elaine G.Y. Chew, Niranjan Nagarajan, Pierre-Étienne Jacques, Jimmy B.Y. So, Xiaoan Ruan, Khay Guan Yeoh, Patrick Tan, Wing-Kin Sung, Walter Hunziker, Yijun Ruan, Axel M. Hillmer
Publikováno v:
Cell Reports, Vol 12, Iss 2, Pp 272-285 (2015)
Genome rearrangements, a hallmark of cancer, can result in gene fusions with oncogenic properties. Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, we analyzed 15 gastric cancers (GCs) from Southeast Asians. Rearrangements were enriched in
Externí odkaz:
https://doaj.org/article/02de0f8a47244f94862edfad662693ff
Publikováno v:
Micromachines, Vol 10, Iss 3, p 165 (2019)
In vitro cell culture models are emerging as promising tools to understand human development, disease progression, and provide reliable, rapid and cost-effective results for drug discovery and screening. In recent years, an increasing number of in vi
Externí odkaz:
https://doaj.org/article/c2e1ea6621ae42819020ba2259e00635