Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Walter Halangk"'
Autor:
Anna S. Gukovskaya, Sudarshan R. Malla, Ujjwal M. Mahajan, Thomas Wartmann, Walter Halangk, F. Ulrich Weiss, Markus M. Lerch, Fred S. Gorelick, Matthias Sendler, Julia Mayerle, Franziska Gisela Thiel, Ali A. Aghdassi, Thomas Reinheckel, Carina De Boni, Burkhard Krueger
Publikováno v:
Cell Mol Life Sci
Premature intrapancreatic trypsinogen activation is widely regarded as an initiating event for acute pancreatitis. Previous studies have alternatively implicated secretory vesicles, endosomes, lysosomes, or autophagosomes/autophagolysosomes as the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924e520cfadcf2234839a9b1e010ee79
https://doi.org/10.1007/s00018-019-03254-7
https://doi.org/10.1007/s00018-019-03254-7
Autor:
Daniel S. John, Matthias Sendler, Julia Mayerle, Markus M. Lerch, F. Ulrich Weiss, Sandrina Maertin, Walter Halangk, Maria Persike, Preshit R. Wagh, Thomas Wartmann, Norbert Schaschke, Burkhard Krüger
Publikováno v:
Journal of Biological Chemistry. 291:14717-14731
Pancreatitis is associated with premature activation of digestive proteases in the pancreas. The lysosomal hydrolase cathepsin B (CTSB) is a known activator of trypsinogen, and its deletion reduces disease severity in experimental pancreatitis. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826ac90a5da156c61e6958daaa449ccf
https://doi.org/10.1074/jbc.m116.718999
https://doi.org/10.1074/jbc.m116.718999
Publikováno v:
The Pancreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::079380c05bf665d3331fef3407d44d69
https://doi.org/10.1002/9781119188421.ch18
https://doi.org/10.1002/9781119188421.ch18
Autor:
Thomas Wartmann, Lorenz Schild, Andreas Gardemann, Ilona Päge, Gerburg Keilhoff, Walter Halangk, Jan-Christian Martens
Publikováno v:
Molecular and Cellular Biochemistry. 400:253-263
Transient hepatic ischemia can cause significant liver injury. A central and early event in ischemia/reperfusion (I/R) injury is the impairment of mitochondria. The phospholipid cardiolipin (CL) is required for efficient mitochondrial function. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d005e3baa0c3d8e8c26243b4a60423
https://doi.org/10.1007/s11010-014-2282-1
https://doi.org/10.1007/s11010-014-2282-1
Autor:
Ezgi Kaya-Aksoy, Katrin J. Ciecielski, Dietrich A. Ruess, Jerzy Adamski, Wilko Weichert, Axel Walch, Hana Algül, Svetlana Voronina, A. V. Tepikin, Götz Hartleben, Jiaoyu Ai, Kalliope N. Diakopoulos, Thomas Wartmann, Kivanc Görgülü, Marija Stevanovic, Achim Krüger, Anna Melissa Schlitter, Marina Lesina, Angeliki Faidra Karpathaki, Alexandra Berninger, Martin Jastroch, Anna Artati, Benjamin Schoeps, Marlena Kowalska, Roland M. Schmid, Bruno Sainz, Derya Kabacaoglu, Walter Halangk, Yue Zhao, Michaela Aichler, S Wörmann, Stephan Herzig, Christos S. Mantzoros, Katja Steiger
Publikováno v:
Gastroenterology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
[Background and Aims]: Cells in pancreatic ductal adenocarcinoma (PDAC) undergo autophagy, but its effects vary with tumor stage and genetic factors. We investigated the consequences of varying levels of the autophagy related 5 (Atg5) protein on panc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ea79698b1a20a100a951af2c1d3ab4
https://doi.org/10.1053/j.gastro.2018.09.053
https://doi.org/10.1053/j.gastro.2018.09.053
Publikováno v:
Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie. 138:471-479
Hintergrund: Die akute Pankreatitis stellt aufgrund einer unkontrollierten Aktivierung der in der Bauchspeicheldruse synthetisierten Verdauungsenzyme eine Erkrankung mit hohem Komplikationspotenzial und stark variablem Verlaufsmuster dar. Da sich die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca09d1dd6aeb0e387fb0665ea6c5b0b5
https://doi.org/10.1055/s-0032-1328099
https://doi.org/10.1055/s-0032-1328099
Autor:
Walter Halangk, Thomas Wex, Sabine Westphal, Holger Amthauer, S. Winckler, Daniela Adolf, Stefan Piatek, Silke Klose
Publikováno v:
Maturitas. 74:363-368
a b s t r a c t Objectives: C-telopeptide crosslaps (CTX) and bone-specific alkaline phosphatase (BAP) do not provide sufficient sensitivity and specificity for diagnosis of osteoporosis. Cathepsin K (CatK), osteoprotegerin (OPG), and receptor activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6af74b5c4ffff19ebe91b940a9fb751
https://doi.org/10.1016/j.maturitas.2013.01.005
https://doi.org/10.1016/j.maturitas.2013.01.005
Autor:
Björn Rabe, Magdalena U. Kurkowski, Patrick Neuhöfer, Walter Halangk, Stefan Rose-John, Akihiko Yoshimura, Roland M. Schmid, Marina Lesina, Liang Song, Thomas Wartmann, Hong Zhang, Matthias Treiber, Gregor Weirich, Hana Algül, Henrik Thorlacius, Dieter Saur, Sara Regnér, Joseph P. Mizgerd
Publikováno v:
Journal of Clinical Investigation; 123(3), pp 1019-1031 (2013)
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b50775440c7307af2f7ff5c3de24d38
https://doi.org/10.1172/jci64931
https://doi.org/10.1172/jci64931
Publikováno v:
Gastroenterology. 144:265-269
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f3ebe5888296932fbe935adcdd0d9bd
https://doi.org/10.1053/j.gastro.2012.12.010
https://doi.org/10.1053/j.gastro.2012.12.010
Autor:
Heiko Witt, S Wörmann, Hans Ulrich Schulz, Matthias Treiber, Walter Halangk, Kalliope N. Diakopoulos, Roland M. Schmid, Marina Lesina, Patrick Neuhöfer, Hana Algül, Song Liang, Christiane Schwerdtfeger, Karen Dlubatz, Henrik Einwächter, Thomas Wartmann, Hong Zhang
Publikováno v:
Gastroenterology. 144:192-201
Background & Aims The transcription factor nuclear factor-κB (NF-κB) (a heterodimer of NF-κB1p50 and RelA) is activated rapidly in acute pancreatitis (AP). However, it is not clear whether NF-κB promotes or protects against AP. We used the NF-κB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abf4870300fa13d5d8724a5e797bb931
https://doi.org/10.1053/j.gastro.2012.09.058
https://doi.org/10.1053/j.gastro.2012.09.058