Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Walter H. Lang"'
Autor:
Michelle M. Martínez-Montemayor, Taotao Ling, Ivette J. Suárez-Arroyo, Gabriela Ortiz-Soto, Camille L. Santiago-Negrón, Mercedes Y. Lacourt-Ventura, Anibal Valentín-Acevedo, Walter H. Lang, Fatima Rivas
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
We previously reported that Ganoderma lucidum extract (GLE) demonstrate significant anti-cancer activity against triple negative inflammatory breast cancer models. Herein, we aimed to elucidate the bioactive compounds of GLE responsible for this anti
Externí odkaz:
https://doaj.org/article/d007338dd510499e9c088d509da2d89c
Publikováno v:
Molecules, Vol 24, Iss 10, p 2012 (2019)
The increasing prevalence of drug resistant and/or high-risk cancers indicate further drug discovery research is required to improve patient outcome. This study outlines a simplified approach to identify lead compounds from natural products against s
Externí odkaz:
https://doaj.org/article/16f70bdfa7474ee49b991481f948f353
Autor:
Gustavo Palacios, Ikbale El Ayachi, Darcie J. Miller, Adaris Rodriguez-Cortes, Jaeki Min, Fatima Rivas, Richard E. Lee, Taotao Ling, Walter H. Lang, Gustavo A. Miranda-Carboni, Elizabeth C. Griffith
Publikováno v:
J Med Chem
The natural product colletoic acid (CA) is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which primarily converts cortisone to the active glucocorticoid (GC) cortisol. Here, CA's mode of action and its potential as a
Autor:
Malia B. Potts, Taotao Ling, Jane E. Craig, Julie Maier, Travis D. Marsico, John C. Bollinger, Fatima Rivas, Joseph T. Opferman, Walter H. Lang, Amit Budhraja
Publikováno v:
Journal of Natural Products. 82:1301-1311
Natural products continue to provide a platform to study biological systems. A bioguided study of cancer cell models led us to a new member of the jatrophane natural products from Jatropha gossypiifolia, which was independently identified and charact
Publikováno v:
Organic & Biomolecular Chemistry. 17:5223-5229
Ergosterol peroxide selectively displays biological activity against a wide range of diseases, however, its mode of action remains unknown. Here we present an efficient synthesis of ergosterol peroxide chemical probes for in vitro anticancer evaluati
Publikováno v:
Molecules
Volume 24
Issue 10
Molecules, Vol 24, Iss 10, p 2012 (2019)
Volume 24
Issue 10
Molecules, Vol 24, Iss 10, p 2012 (2019)
The increasing prevalence of drug resistant and/or high-risk cancers indicate further drug discovery research is required to improve patient outcome. This study outlines a simplified approach to identify lead compounds from natural products against s
Autor:
Michelle M, Martínez-Montemayor, Taotao, Ling, Ivette J, Suárez-Arroyo, Gabriela, Ortiz-Soto, Camille L, Santiago-Negrón, Mercedes Y, Lacourt-Ventura, Anibal, Valentín-Acevedo, Walter H, Lang, Fatima, Rivas
Publikováno v:
Frontiers in Pharmacology
We previously reported that Ganoderma lucidum extract (GLE) demonstrate significant anti-cancer activity against triple negative inflammatory breast cancer models. Herein, we aimed to elucidate the bioactive compounds of GLE responsible for this anti
Autor:
Walter H. Lang, Taotao Ling, Cynthia Jeffries, Anang A. Shelat, Sourav Das, Fatima Rivas, Julie Maier, Xiang Feng
Publikováno v:
European journal of medicinal chemistry. 146
Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children. Up to a quarter of ALL patients relapse and face poor prognosis. To identify new compound leads, we conducted a phenotypic screen using terrestrial natural product (N
Autor:
John A. Sandoval, Jianrong Wu, Christopher L. Morton, Walter H. Lang, Eric D. Villarreal, William Preston Hewgley, Shenghua Mao
Publikováno v:
The Journal of surgical research. 218
Background Contained in-bag spleen morcellation is a conventional extraction technique for safe spleen removal during laparoscopic splenectomy. Existing data for the use of in-bag enzymatic splenic digestion as an alternative to morcellation are lack
Autor:
John A. Sandoval, Walter H. Lang
Publikováno v:
SLAS Discovery. 19:1235-1245
Neuroblastoma (NB) is a common solid tumor in children. Outcomes for advanced stage NB have not improved, at least in part because of multimodality therapy resistance. Better comprehension of novel molecular targets will likely lead to improved thera