Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Walter Glaser"'
Autor:
Michael Riedelberger, Philipp Penninger, Michael Tscherner, Bernhard Hadriga, Carina Brunnhofer, Sabrina Jenull, Anton Stoiber, Christelle Bourgeois, Andriy Petryshyn, Walter Glaser, Andreas Limbeck, Michael A. Lynes, Gernot Schabbauer, Guenter Weiss, Karl Kuchler
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Host and fungal pathogens compete for metal ion acquisition during infectious processes, but molecular mechanisms remain largely unknown. Here, we show that type I interferons (IFNs-I) dysregulate zinc homeostasis in macrophages, which emplo
Externí odkaz:
https://doaj.org/article/20189ec086c24357bfbc0929fda069b3
Autor:
Tobias Schwarzmüller, Biao Ma, Ekkehard Hiller, Fabian Istel, Michael Tscherner, Sascha Brunke, Lauren Ames, Arnaud Firon, Brian Green, Vitor Cabral, Marina Marcet-Houben, Ilse D Jacobsen, Jessica Quintin, Katja Seider, Ingrid Frohner, Walter Glaser, Helmut Jungwirth, Sophie Bachellier-Bassi, Murielle Chauvel, Ute Zeidler, Dominique Ferrandon, Toni Gabaldón, Bernhard Hube, Christophe d'Enfert, Steffen Rupp, Brendan Cormack, Ken Haynes, Karl Kuchler
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004211 (2014)
The opportunistic fungal pathogen Candida glabrata is a frequent cause of candidiasis, causing infections ranging from superficial to life-threatening disseminated disease. The inherent tolerance of C. glabrata to azole drugs makes this pathogen a se
Externí odkaz:
https://doaj.org/article/986a5b5ef3804428b35fc96b095e2b8a
Autor:
Dagmar Hosiner, Susanne Gerber, Hella Lichtenberg-Fraté, Walter Glaser, Christoph Schüller, Edda Klipp
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83330 (2014)
Although considered as essential cofactors for a variety of enzymatic reactions and for important structural and functional roles in cell metabolism, metals at high concentrations are potent toxic pollutants and pose complex biochemical problems for
Externí odkaz:
https://doaj.org/article/57f2b3b854a14c6b8c7c82d79e682deb
Autor:
Denes Hnisz, Anaïs F Bardet, Clarissa J Nobile, Andriy Petryshyn, Walter Glaser, Ulrike Schöck, Alexander Stark, Karl Kuchler
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003118 (2012)
Despite their classical role as transcriptional repressors, several histone deacetylases, including the baker's yeast Set3/Hos2 complex (Set3C), facilitate gene expression. In the dimorphic human pathogen Candida albicans, the homologue of the Set3C
Externí odkaz:
https://doaj.org/article/9cd85b53ede045feb27c325ca3a63fd7
Autor:
Bernhard Hadriga, Andriy Petryshyn, Anton Stoiber, Walter Glaser, Michael A. Lynes, Sabrina Jenull, Michael Riedelberger, Andreas Limbeck, Carina Brunnhofer, Karl Kuchler, Guenter Weiss, Philipp Penninger, Christelle Bourgeois, Gernot Schabbauer, Michael Tscherner
Publikováno v:
iScience
iScience, Vol 23, Iss 5, Pp-(2020)
iScience, Vol 23, Iss 5, Pp-(2020)
Summary Host and fungal pathogens compete for metal ion acquisition during infectious processes, but molecular mechanisms remain largely unknown. Here, we show that type I interferons (IFNs-I) dysregulate zinc homeostasis in macrophages, which employ
Autor:
Birgit Strobl, Andreas Limbeck, Sabrina Jenull, Bernhard Scheidl, Irina Tsymala, Andriy Petryshyn, Markus Seifert, Guenter Weiss, Carina Brunnhofer, Karl Kuchler, Walter Glaser, Christelle Bourgeois, Philipp Penninger, Michael Tscherner, Michael Riedelberger
Publikováno v:
Cell Host & Microbe. 27:454-466.e8
Summary Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis
Autor:
Steffen Rupp, Walter Glaser, Karl Kuchler, Cristina Reinoso-Martín, Ingrid E. Frohner, Christoph Schüller, Christa Gregori
Publikováno v:
Eukaryotic Cell. 10:1694-1704
Echinocandin drugs such as caspofungin (CASP), micafungin, and anidulafungin inhibit fungal cell wall biogenesis by blocking Fks1-mediated β-glucan deposition into the cell surface. Candins have become suitable drugs to treat life-threatening diseas
Autor:
Karl Kuchler, Walter Glaser, Christelle Bourgeois, Ingrid E. Frohner, Mathias Müller, Iwona Lesiak-Markowicz, Olivia Majer, Silvia Stockinger, Kwang-Soo Hildering, Shizuo Akira, Thomas Decker
Publikováno v:
The Journal of Immunology
Human fungal pathogens such as the dimorphic Candida albicans or the yeast-like Candida glabrata can cause systemic candidiasis of high mortality in immunocompromised individuals. Innate immune cells such as dendritic cells and macrophages establish
Publikováno v:
OMICS: A Journal of Integrative Biology. 14:651-663
Pyrrolidine dithiocarbamate (PDTC), a known inhibitor of NFκB activation, has antioxidative as well as antiviral activities. PDTC is effective against several virus families, indicating that its antiviral mechanism targets host rather than viral fun
Publikováno v:
Transporters as Drug Carriers