Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Walter Georgescu"'
Autor:
Walter Georgescu, Alma Osseiran, Maria Rojec, Yueyong Liu, Maxime Bombrun, Jonathan Tang, Sylvain V Costes
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129438 (2015)
Traditionally, the kinetics of DNA repair have been estimated using immunocytochemistry by labeling proteins involved in the DNA damage response (DDR) with fluorescent markers in a fixed cell assay. However, detailed knowledge of DDR dynamics across
Externí odkaz:
https://doaj.org/article/229e19248d324b28be298064c49de002
Autor:
Maria Rojec, Walter Georgescu, Maxime Bombrun, Jonathan Tang, Yueyong Liu, Sylvain V. Costes, Alma Osseiran
Publikováno v:
Georgescu, W; Osseiran, A; Rojec, M; Liu, Y; Bombrun, M; Tang, J; et al.(2015). Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis. PLoS One, 10(6). Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/04k6j87r
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0129438 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0129438 (2015)
Traditionally, the kinetics of DNA repair have been estimated using immunocytochemistry by labeling proteins involved in the DNA damage response (DDR) with fluorescent markers in a fixed cell assay. However, detailed knowledge of DDR dynamics across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b40710c0cc297310c3330548a804b8
http://www.escholarship.org/uc/item/04k6j87r
http://www.escholarship.org/uc/item/04k6j87r
Publikováno v:
Cancer Metastasis-Biology and Treatment ISBN: 9783319121352
The constant damage of DNA in human cells is considered the main cause of aging and cancer. In this review, we discuss the most lethal form of DNA damage, the DNA double strand break (DSB), and how it relates to cancer. DSB sensor proteins in the nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::466754f54aeb966daa5e40fd39add2a8
https://doi.org/10.1007/978-3-319-12136-9_4
https://doi.org/10.1007/978-3-319-12136-9_4
Autor:
Nicole L. Diggins, Donna J. Webb, Vito Quaranta, Walter Georgescu, Joshua A. Broussard, Stephen G. Hummel
Publikováno v:
Scientific Reports
Cell-matrix adhesions are of great interest because of their contribution to numerous biological processes, including cell migration, differentiation, proliferation, survival, tissue morphogenesis, wound healing and tumorigenesis. Adhesions are dynam
Publikováno v:
Chiolo, Irene; Georgescu, Walter; Tang, Jonathan; & Costes, Sylvain V.(2013). Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin. Mutation Research. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/94f522ks
Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity. While much is known about the molecular mechanisms involved in DSB repair and checkpoint activation, the roles of nuclear dynamics of radiation-induced foci (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d77a7414f200fda3de3d8fae6a2984c
http://www.escholarship.org/uc/item/94f522ks
http://www.escholarship.org/uc/item/94f522ks
Autor:
Kazi M. Ahmed, Catherine C. Park, Hui Zhang, Sylvain V. Costes, Aris Polyzos, Walter Georgescu, Christopher K. Pham
Three-dimensional (3D) tissue culture provides a physiologically relevant microenvironment for distinguishing malignant from non-malignant breast cell phenotypes. 3D culture assay can also be used to test novel cancer therapies and predict a differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab23f1413d07b839caf7ad00d0f986b
https://europepmc.org/articles/PMC3641787/
https://europepmc.org/articles/PMC3641787/
Publikováno v:
Bioinformatics (Oxford, England). 28(1)
Motivation: Advances in microscopy technology have led to the creation of high-throughput microscopes that are capable of generating several hundred gigabytes of images in a few days. Analyzing such wealth of data manually is nearly impossible and re
Autor:
Brandy Weidow, Vito Quaranta, Shawn P. Garbett, Mark P. Harris, Darren R. Tyson, Walter Georgescu
Publikováno v:
Methods in enzymology. 467
Mapping quantitative cell traits (QCT) to underlying molecular defects is a central challenge in cancer research because heterogeneity at all biological scales, from genes to cells to populations, is recognized as the main driver of cancer progressio
Autor:
Vito Quaranta, Walter Georgescu, Lourdes Estrada, Jerome Jourquin, John P. Wikswo, Alexander R. A. Anderson
Historically, it has been difficult to generate accurate and reproducible protein gradients for studies of interactions between cells and extracellular matrix. Here we demonstrate a method for rapid patterning of protein gradients using computer-driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217f43aefe79b2f678631105b8164d6c
https://europepmc.org/articles/PMC4357342/
https://europepmc.org/articles/PMC4357342/
Autor:
Walter Georgescu, Jerome Jourquin, Lourdes Estrada, Alexander R. A. Anderson, Vito Quaranta, John P. Wikswo
Publikováno v:
Lab on a Chip; Jan2008, Vol. 8 Issue 2, p238-244, 7p