Výsledky vyhledávání - "Walter G. Smith"

Pharmacology of Celecoxib in Rat Brain after Kainate Administration

Autor: Paola Ciceri, Walter G. Smith, Kathleen M. Leahy, Karen Seibert, Peter C. Isakson, Yan Zhang, Alex Shaffer, Mark B. Woerner

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 302:846-852

Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its formation in both locations is blocked by cyclooxygenase-2 (COX-2) inhibitors such as celecoxib.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f10b64c5dfbafa5f45a1f8abb38ba4
https://doi.org/10.1124/jpet.302.3.846

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Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid

Autor: Walter G. Smith, Suzanne H Kim, Doreen Villani-Price, Matthew W Mahoney, Nayereh S Ghoreishi-Haack, Helen Y. Chen, Thomas D. Penning, Stella Siu-Tzyy Yu, James W. Malecha, Leslie J Askonas, Chi-Dean Liang, Elizabeth I Harding, E.Yvonne Pyla, Maureen K Highkin, James K. Gierse, Julie M Miyashiro, Mark A Russell, James F Kachur, Chen Barbara B

Publikováno v: Journal of Medicinal Chemistry. 45:3482-3490

Leukotriene B(4) (LTB(4)) is a potent, proinflammatory mediator involved in the pathogenesis of a number of diseases including inflammatory bowel disease, psoriasis, rheumatoid arthritis, and asthma. The enzyme LTA(4) hydrolase represents an attracti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aaaeb42023ad7fd78de02ecc724a97
https://doi.org/10.1021/jm0200916

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Pharmacological Characterization of SC-57461A (3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid HCl), a Potent and Selective Inhibitor of Leukotriene A4Hydrolase I: In Vitro Studies

Autor: Leslie J Askonas, Mark A Russell, Walter G. Smith, James F. Kachur, Chi-Dean D. Liang, D Villani-Price

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 300:577-582

Leukotriene (LT) A(4) hydrolase is a dual function enzyme that is essential for the conversion of LTA(4) to LTB(4) and also possesses an aminopeptidase activity. SC-57461A (3-[methyl[3-[4-phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl) is a pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a43488c1feb896fd592f6e43e83a9e0
https://doi.org/10.1124/jpet.300.2.577

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Promegapoietin‐1a, an Engineered Chimeric IL‐3 and Mpl‐L Receptor Agonist, Stimulates Hematopoietic Recovery in Conventional and Abbreviated Schedules Following Radiation‐Induced Myelosuppression in Nonhuman Primates

Autor: John P. Mckearn, Judith G. Giri, Walter G. Smith, Ned R. Siegel, Ann M. Farese, Thomas J. MacVittie

Publikováno v: STEM CELLS. 19:329-338

Promegapoietin-1a (PMP-1a), a multifunctional agonist for the human interleukin 3 and Mpl receptors, was evaluated for its ability to stimulate hematopoietic reconstitution in nonhuman primates following severe radiation-induced myelosuppression. Ani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b768cc1a8fc1d859334857dedd9ab291
https://doi.org/10.1634/stemcells.19-4-329

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Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression

Autor: Walter G. Smith, Thomas J. MacVittie, Charles M. Baum, Ann M. Farese, Earl Burton, John P. McKearn

Publikováno v: Blood. 95:837-845

Myelopoietins (MPOs) constitute a family of engineered, chimeric molecules that bind and activate the IL-3 and G-CSF receptors on hematopoietic cells. This study investigated the in vivo hematopoietic response of rhesus monkeys administered MPO after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22ccd6498890227070fb6bf427932476
https://doi.org/10.1182/blood.v95.3.837.003k08_837_845

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Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase

Publikováno v: Journal of Medicinal Chemistry. 43:721-735

Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. Since the action of LTA(4) hydrolase is the rate-limiting step for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2c8b8f857645ec82bda0e73ed60429
https://doi.org/10.1021/jm990496z

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Rapid and selective induction of blood eosinophilia in guinea pigs by recombinant human interleukin 5

Autor: Joseph Portanova, Robert P. Compton, Shaukat H. Rangwala, Jeffrey L. Hirsch, Lori J. Christine, Joseph B. Monahan, Walter G. Smith

Publikováno v: Cytokine. 7:775-783

Interleukin 5 (IL-5) has been implicated as a causal mediator in the development of pulmonary eosinophilia and airway hyperreactivity in human asthma. Supportive evidence for a pathogenic role of IL-5 in this disease has been provided by guinea pig m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84198f1cc1dac29a833ea99ca1aca801
https://doi.org/10.1006/cyto.1995.0093

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INITIAL STUDIES ON THE EFFECT OF INHALED MISOPROSTOL IN A GUINEA PIG MODEL OF ALLERGIC BRONCHOCONSTRICTION

Autor: Nayereh S. Souresrafil, Walter G. Smith, Janice M. Thompson, John P. McKearn

Publikováno v: American Journal of Therapeutics. 2:755-760

Inhaled E series prostaglandins (PGEs) have been shown to modulate responses to both allergic and nonallergic provocation. Little is known about the effect of inhaled misoprostol on the airway and whether its antiasthmatic activity would be similar t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4118761f84e479448fe650b0ceb1a2
https://doi.org/10.1097/00045391-199510000-00004

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Synthesis of Imidazopyridines and Purines as Potent Inhibitors of Leukotriene A4 Hydrolase

Autor: Doreen Villani-Price, Suzanne H Kim, Walter G. Smith, Leslie J Askonas, Elizabeth I Harding, Maureen K Highkin, Thomas D. Penning, Alan F. Gasiecki, Nayereh S Ghoreishi-Haack, Nizal S Chandrakumar, E.Yvonne Pyla, Bipin N Desai, James F Kachur, Mark A Russell, Stevan W Djuric, James W. Malecha, James K. Gierse, Julie M Miyashiro

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:1137-1139

The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excelle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830ee52b64cb2d30d9d134d0185d9a9
https://doi.org/10.1016/s0960-894x(03)00039-8

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Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

Autor: Kathleen M. Leahy, Pamela T. Manning, Jaime L. Masferrer, Peter C. Isakson, Scott D. Hauser, Walter G. Smith, Ben S. Zweifel, Karen Seibert

Publikováno v: Proceedings of the National Academy of Sciences. 91:3228-3232

We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99310470116d6ee48c8bcc8505e77a5
https://doi.org/10.1073/pnas.91.8.3228

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