Zobrazeno 1 - 10
of 522
pro vyhledávání: '"Walter F, Bodmer"'
Autor:
Shamir Montazid, Sheila Bandyopadhyay, Daniel W. Hart, Nan Gao, Brian Johnson, Sri G. Thrumurthy, Dustin J. Penn, Bettina Wernisch, Mukesh Bansal, Philipp M. Altrock, Fabian Rost, Patrycja Gazinska, Piotr Ziolkowski, Bu’Hussain Hayee, Yue Liu, Jiangmeng Han, Annamaria Tessitore, Jana Koth, Walter F. Bodmer, James E. East, Nigel C. Bennett, Ian Tomlinson, Shazia Irshad
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity and tissue function with increasing lifespan. Using cumulative BrdU
Externí odkaz:
https://doaj.org/article/be2026cd202c4604a72718d25fbf1ee3
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-27 (2022)
Abstract Background Cancer evolution consists of a stepwise acquisition of genetic and epigenetic changes, which alter the gene expression profiles of cells in a particular tissue and result in phenotypic alterations acted upon by natural selection.
Externí odkaz:
https://doaj.org/article/a952caed416647dcb69888e0b921ee38
Autor:
Johanna Michl, Stefania Monterisi, Bobby White, Wiktoria Blaszczak, Alzbeta Hulikova, Gulnar Abdullayeva, Esther Bridges, Zinan Yin, Walter F. Bodmer, Pawel Swietach
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112601- (2023)
Summary: Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe). Raised pHi is thought to be
Externí odkaz:
https://doaj.org/article/fa74c4cb09b5443a9fcec040cffeaf11
Autor:
Jin Cheon Kim, Walter F. Bodmer
Publikováno v:
Annals of Coloproctology, Vol 37, Iss 6, Pp 368-381 (2021)
The genomic causes and clinical manifestations of hereditary colorectal cancer (HCRC) might be stratified into 2 groups, namely, familial (FCRC) and a limited sense of HCRC, respectively. Otherwise, FCRC is canonically classified into 2 major categor
Externí odkaz:
https://doaj.org/article/003b015476fa43f0bec6eb4c61a57707
Autor:
Stefania Monterisi, Johanna Michl, Alzbeta Hulikova, Jana Koth, Esther M Bridges, Amaryllis E Hill, Gulnar Abdullayeva, Walter F Bodmer, Pawel Swietach
Publikováno v:
eLife, Vol 11 (2022)
Growth of cancer cells in vitro can be attenuated by genetically inactivating selected metabolic pathways. However, loss-of-function mutations in metabolic pathways are not negatively selected in human cancers, indicating that these genes are not ess
Externí odkaz:
https://doaj.org/article/6873e0339c734b01bab661f7fa921019
Autor:
Johanna Michl, Yunyi Wang, Stefania Monterisi, Wiktoria Blaszczak, Ryan Beveridge, Esther M. Bridges, Jana Koth, Walter F. Bodmer, Pawel Swietach
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110493- (2022)
Summary: Unlike most cell types, many cancer cells survive at low extracellular pH (pHe), a chemical signature of tumors. Genes that facilitate survival under acid stress are therefore potential targets for cancer therapies. We performed a genome-wid
Externí odkaz:
https://doaj.org/article/696d8f39d93a4311848ebb92e14a06d8
Autor:
Oliver M. Sieber, John M. Mariadason, Walter F. Bodmer, Ian P.M. Tomlinson, David Bicknell, Jennifer L. Wilding, Liam O'Connor, Samuel Wormald, Daniel Buchanan, Robert L. Strausberg, Diego Arango, Antony W. Burgess, Shan Li, Christopher G. Love, Robert N. Jorissen, Clare Sloggett, Dmitri Mouradov
Comparison of POLE mutation spectra between 9 NSHP and 15 non-NSHP CRC cell lines and TCGA-analyzed primary cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd93784b46f3cb5fc6841fddcfc4295a
https://doi.org/10.1158/0008-5472.22403840
https://doi.org/10.1158/0008-5472.22403840
Autor:
Oliver M. Sieber, John M. Mariadason, Walter F. Bodmer, Ian P.M. Tomlinson, David Bicknell, Jennifer L. Wilding, Liam O'Connor, Samuel Wormald, Daniel Buchanan, Robert L. Strausberg, Diego Arango, Antony W. Burgess, Shan Li, Christopher G. Love, Robert N. Jorissen, Clare Sloggett, Dmitri Mouradov
XLSX file - 23KB, CRC cell line details and major molecular hallmarks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0beb6b1b1aa21b768e4b588328a623d2
https://doi.org/10.1158/0008-5472.22403882.v1
https://doi.org/10.1158/0008-5472.22403882.v1
Autor:
Valentine M. Macaulay, Christopher J. Lord, Alan Ashworth, Mark R. Middleton, Walter F. Bodmer, Jennifer L. Wilding, Shazad Q. Ashraf, George Thalmann, Terry M. Jones, Nav Upile, Jean-Pascal Machiels, Sandra Schmitz, Jean-Yves Blay, Nicholas Athanasou, Takeshi Kashima, Stephan Feller, Deborah Bailey, Paul Allen, Cheng Han, Ruth Asher, Tamara Aleksic, Djamila Ouaret, Asha Kigozi, Clare Verrill, Ilirjana Bajrami, Shan Gao
Supplementary Figure Legend. Legends for Supplementary Figures S1-S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4760ae5aef14e6f057f503e4a4934c01
https://doi.org/10.1158/0008-5472.22403451
https://doi.org/10.1158/0008-5472.22403451
Autor:
Oliver M. Sieber, John M. Mariadason, Walter F. Bodmer, Ian P.M. Tomlinson, David Bicknell, Jennifer L. Wilding, Liam O'Connor, Samuel Wormald, Daniel Buchanan, Robert L. Strausberg, Diego Arango, Antony W. Burgess, Shan Li, Christopher G. Love, Robert N. Jorissen, Clare Sloggett, Dmitri Mouradov
XLSX file - 90KB, Top 5% of mutated genes based on the proportion of affected samples in CRC cell lines and TCGA-analyzed primary cancers for non-hypermutated and hypermutated MSI-H samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556f07bf75f76b3ff6a9ca7318373a4d
https://doi.org/10.1158/0008-5472.22403858.v1
https://doi.org/10.1158/0008-5472.22403858.v1