Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Walter Elger"'
Autor:
Z. Killeen, Hareesh B. Nair, Walter Elger, Klaus Nickisch, Meece Fa, H. Schubert, G. Ahmed, B. Santhamma, Reinhard Meister, R. Wyrwa, Birgitt Schneider
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 165:305-311
Oral compared to parenteral estrogen administration is characterized by reduced systemic but prominent hepatic estrogenic effects on lipids, hemostatic factors, GH-/IGF I axis, angiotensinogen. In order to avoid such adverse metabolic effects of oral
Autor:
Walter Elger, Kristof Chwalisz, Evan R. Myers, B. Schwefel, Michael P. Diamond, Robert A. Feldman, Elizabeth A. Stewart, Bruce R. Carr, C. Mattia-Goldberg, Alistair R.W. Williams
Publikováno v:
Hum Reprod
Stewart, E A, Diamond, M P, Williams, A, Carr, B R, Myers, R E, Feldman, R, Elger, W, Mattia-Goldberg, C, Schwefel, B M & Chwalisz, K 2019, ' Safety and Efficacy of the Selective Progesterone Receptor Modulator Asoprisnil for Heavy Menstrual Bleeding With Uterine Fibroids: Pooled Analysis of Two 12-Month, Placebo-Controlled, Randomized Trials ', Human Reproduction, pp. 1-12 . https://doi.org/10.1093/humrep/dez007
Stewart, E A, Diamond, M P, Williams, A, Carr, B R, Myers, R E, Feldman, R, Elger, W, Mattia-Goldberg, C, Schwefel, B M & Chwalisz, K 2019, ' Safety and Efficacy of the Selective Progesterone Receptor Modulator Asoprisnil for Heavy Menstrual Bleeding With Uterine Fibroids: Pooled Analysis of Two 12-Month, Placebo-Controlled, Randomized Trials ', Human Reproduction, pp. 1-12 . https://doi.org/10.1093/humrep/dez007
STUDY QUESTION Can asoprisnil, a selective progesterone receptor modulator, provide clinically meaningful improvements in heavy menstrual bleeding (HMB) associated with uterine fibroids with an acceptable safety profile? SUMMARY ANSWER Uninterrupted
Autor:
Klaus Nickisch, R. Wedemeyer, M. Dehnhard, Birgitt Schneider, M. Friedrich, Z. Killeen, K. Jewgenow, Walter Elger, B. Santhamma
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 183
A guinea pig model for new HEC methods is proposed. Two targets for HEC (Hormonal Emergency Contraception), ovulation and conception (post-mating study), were investigated using adjusted PRM treatments: (a) Ovulation inhibition study: Injections on c
Autor:
Birgitt Schneider, Klaus Nickisch, Hareesh B. Nair, Wyrwa Ralf, Walter Elger, Gulzar Ahmed, Frederick Meece
Publikováno v:
Bioorganicmedicinal chemistry. 25(20)
A series of estradiol-17-β esters of N-(p-sulfomylbenzamide)-amino acids were prepared and evaluated for systemic and hepatic estrogenic activity after oral administration in ovariectomized rats. The alkyl substitution at nitrogen of amino acids suc
Autor:
Klaus Nickisch, Shao-Qing Shi, Robert E. Garfield, Olga Amelkina, Narkunan Kesavaram, Baishakhi Das, Walter Elger, Reinhard Meister, James W. Cessac
Publikováno v:
Steroids. 78:255-267
A series of antiprogestins have been synthesized by partially fluorinating the steroid molecule in positions relevant for receptor binding. By introducing fluorine at the exo-methylene of the 17 spirofuran ring, we obtained partial agonists (mesoprog
Autor:
Dorota Kowalik, Walter Elger, Andrea Rosinus, Dominga Deluca, Gabriele Möller, Peter Droescher, Christian Gege, Alexander Hillisch, Olaf Peters, Jerzy Adamski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6740-6744
In search for specific drugs against steroid-dependent cancers we have developed a novel set of potent inhibitors of steroidogenic human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD 1). The X-ray structure of 17beta-HSD 1 in complex with es
Autor:
Deborah A. DeManno, Gerd Schubert, Maria Claudia Perez, Kristof Chwalisz, Walter Elger, Craig Winkel
Publikováno v:
Endocrine Reviews. 26:423-438
Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands. SPRMs exert clinically relevant tissue-selective progesterone agonist, antagonist, or mixed agonist/antagonist effects on various progesterone
Autor:
Dirk Kosemund, Walter Elger, Karl-Heinrich Fritzemeier, Alexander Hillisch, Olaf Peters, Birgitt Schneider, Gerd Müller, Gudrun Reddersen, Alexander Walter
Publikováno v:
Molecular Endocrinology. 18:1599-1609
The distinct roles of the two estrogen receptor (ER) isotypes, ERalpha and ERbeta, in mediating the physiological responses to estrogens are not completely understood. Although knockout animal experiments have been aiding to gain insight into estroge
Autor:
Shao Qing Shi, Robert E. Garfield, Alexander Hillisch, Kunhard Pollow, Walter Elger, Sybille Beier
Publikováno v:
Steroids. 68:891-905
Progesterone is more than a progestin. Beyond functions in cycle and pregnancy, progesterone binds with high affinity to the mineralocorticoid receptor (MR) acting as an antagonist, with obvious significance for electrolyte homeostasis, an array of M
Autor:
Birgitt Schneider, Bernd Menzenbach, Peter Droescher, Alexander Hillisch, Walter Elger, Johannes von Langen, Günter Kaufmann
Publikováno v:
Steroids. 68:869-878
Polar functional groups in the A- and D-ring (positions 3 and 17beta or 20) are common to all natural and synthetic steroid hormones. It was assumed that these pharmacophoric groups are involved in strong hydrogen bonding interactions with the respec