Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Walter Edward Bradley"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1309:1-4
We report the isolation and characterization of genomic sequences coding for the 5' end of human retinoic acid receptor beta 1, a fetal RAR isoform which is also expressed in small cell lung cancers. Primer extension analysis revealed a principal tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59df7c72b9f93859b2d19795017064dd
https://doi.org/10.1016/s0167-4781(96)00126-1
https://doi.org/10.1016/s0167-4781(96)00126-1
Publikováno v:
Proceedings of the National Academy of Sciences. 90:985-989
Retinoic acid receptor beta (RAR beta), which codes for a nuclear receptor for retinoic acid, is localized in a chromosomal region frequently deleted in lung cancer cells. The gene is expressed in normal lung tissue and in the majority of the cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feffadd49394bbe6719db61ce626985b
https://doi.org/10.1073/pnas.90.3.985
https://doi.org/10.1073/pnas.90.3.985
Autor:
Peter L Szego, Helene Fournier, Jean-Michel Vidal, Bruno Paquin, Susanna Nikolaus, Walter Edward Bradley, Sophie Debrus, Hilary Clark, Paul Van Eerdewegh, Stefan Schreiber, René J. A. Paulussen, René Allard, Quynh Nguyen-Huu, Nathalie Laplante, Gunnar Jacobs, Pascal Croteau, Philip Rosenstiel, Tim Keith, Andre Franke, Randall D. Little, Jonathan Segal, Andreas Ruether, John W. Hooper, Abdelmajid Belouchi, John Verner Raelson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(37)
Genome-wide association (GWA) studies offer a powerful unbiased method for the identification of multiple susceptibility genes for complex diseases. Here we report the results of a GWA study for Crohn's disease (CD) using family trios from the Quebec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd1341323260b282a2818d95c032e54
https://pubmed.ncbi.nlm.nih.gov/17804789
https://pubmed.ncbi.nlm.nih.gov/17804789
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 93(1)
High-density mutational spectra have been established for exon 3 of the gene encoding adenine phosphoribosyltransferase (APRT) of the Chinese hamster ovary (CHO) cell line derivative D422 and closely related and/or modified lines by using the mutagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ef0c6167311dbc3b15185ddb01d4d8
https://pubmed.ncbi.nlm.nih.gov/8552587
https://pubmed.ncbi.nlm.nih.gov/8552587
Publikováno v:
Mutation research. 266(2)
Early work with adenine phosphoribosyltransferase-deficient mutants of CHO cells suggested that a site existed in the third exon of this gene which was preferentially susceptible to mutation by ethyl methanesulphonate. To determine whether this was r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8361c86ea259fb4400a841d9ccbf9254
https://pubmed.ncbi.nlm.nih.gov/1373832
https://pubmed.ncbi.nlm.nih.gov/1373832
Publikováno v:
Genes, chromosomescancer. 3(5)
We report a higher frequency of loss of heterozygosity at loci on the short arm of chromosome 3 in human epidermoid lung tumors than in other non-small cell lung tumors. This observation together with the already known involvement of the retinoids in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de9e74475cfd558f3bd1315dad41d10
https://pubmed.ncbi.nlm.nih.gov/1665705
https://pubmed.ncbi.nlm.nih.gov/1665705
Publikováno v:
Somatic cell and molecular genetics. 17(3)
We have determined the nucleotide sequence surrounding a BclI restriction fragment length variation near the aprt gene of CHO cells. By BclI digestion of the PCR-amplified DNA from a variety of APRT-deficient mutants derived from CHO cells, we were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a1ee9a826865d5e084183c8c663d84
https://pubmed.ncbi.nlm.nih.gov/1675490
https://pubmed.ncbi.nlm.nih.gov/1675490
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 199:131-138
Frequencies of mutation at the hprt and aprt loci in various CHO cell lines were measured after exposure of the cells to ionizing radiation. In D423 and AA8-16, which are aprt +/− heterozygotes, the ratio of hprt − mutants to aprt − mutants ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006e12870c302ea191a423b7893c2508
https://doi.org/10.1016/0027-5107(88)90238-2
https://doi.org/10.1016/0027-5107(88)90238-2
Autor:
Walter Edward Bradley, Karen Messing
Publikováno v:
Carcinogenesis. 7:1451-1455
Five populations of Chinese hamster ovary cells were exposed to daily doses of 40 mGy of gamma-radiation and sampled weekly for thioguanine-resistant mutant frequency. Over a period of 2-3 months, mutants appeared at frequencies above background in f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a77a3800e53d952a38acc7f6d513ce
https://doi.org/10.1093/carcin/7.9.1451
https://doi.org/10.1093/carcin/7.9.1451
Publikováno v:
Health physics. 57(4)
The frequency of hypoxanthine phosphoribosyl transferase (HPRT) mutants among peripheral T-lymphocytes of radiotherapy technicians primarily exposed to 60Co was measured by the T-cell cloning method. Mutant frequencies of these technicians in 1984 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878d904b87c6d903518cc351d1bc704d
https://pubmed.ncbi.nlm.nih.gov/2793468
https://pubmed.ncbi.nlm.nih.gov/2793468