Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Walter E. Mushynski"'
Autor:
Daniel Larocque, Gabriela Fragoso, Jinghan Huang, Walter E Mushynski, Martin Loignon, Stéphane Richard, Guillermina Almazan
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5867 (2009)
BACKGROUND:The quaking viable (qk(v)) mice have uncompacted myelin in their central and peripheral nervous system (CNS, PNS). The qk gene encodes 3 major alternatively spliced isoforms that contain unique sequence at their C-terminus dictating their
Externí odkaz:
https://doaj.org/article/689ebfdfc6a3481592630c7b8556ebea
Autor:
Gabriela Fragoso, Qiao Ling Cui, Veronique E. Miron, Walter E. Mushynski, Peter J. Darlington, Guillermina Almazan, Jack P. Antel
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 69:930-944
We examined the effects of growth factors and axonal signals on the differentiation of human fetal and adult oligodendrocyte progenitor cells (OPCs) and determined whether these effects translated into enhanced axonal ensheathment. Only small numbers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b050e3c0b088010f25c5da87dc445b
https://doi.org/10.1097/nen.0b013e3181ef3be4
https://doi.org/10.1097/nen.0b013e3181ef3be4
Publikováno v:
Glia. 58:1384-1393
The p38 mitogen-activated protein kinases (p38 MAPKs) are a family of kinases that regulate a number of cellular functions including cell migration, proliferation, and differentiation. We have previously reported a role for p38 MAPK in the regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::718ce45ecac5ff49e4d317df33554877
https://doi.org/10.1002/glia.21014
https://doi.org/10.1002/glia.21014
Autor:
Martin A. Bruno, Walter E. Mushynski, A. Claudio Cuello, Guillermina Almazan, Wanda Leon, Gabriela Fragoso
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 68:857-869
We previously reported that the precursor form of nerve growth factor (pro-NGF) and not mature NGF is liberated in the CNS in an activity-dependent manner, and that its maturation and degradation occur in the extracellular space by the coordinated ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab07931fb2fad18621f34faa94381802
https://doi.org/10.1097/nen.0b013e3181aed9e6
https://doi.org/10.1097/nen.0b013e3181aed9e6
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 68:642-652
Mutations in NEFL encoding the light neurofilament subunit (NFL) cause Charcot-Marie-Tooth disease type 2E (CMT2E), which affects both motor and sensory neurons. We expressed the disease-causing mutants NFL and NFL in motor neurons of dissociated spi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450e2adbda3b9828f2c4a8b600330c96
https://doi.org/10.1097/nen.0b013e3181a5deeb
https://doi.org/10.1097/nen.0b013e3181a5deeb
Publikováno v:
Journal of Neurochemistry. 47:477-483
Exhaustive in vitro dephosphorylation of porcine neurofilaments (NFs) by alkaline or acid phospha-tase did not cause a dissociation of the 210–kD (NF-H), 160–kD (NF-M), or 70–kD (NF-L) subunits and had no effect on the reassembly of NFs from ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9452769da9291749da97da8aa79ca9
https://doi.org/10.1111/j.1471-4159.1986.tb04526.x
https://doi.org/10.1111/j.1471-4159.1986.tb04526.x
Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice
Publikováno v:
Virology
The notion that an infectious respiratory pathogen can damage the central nervous system (CNS) and lead to neurological disease was tested using a human respiratory coronavirus, the OC43 strain of human coronavirus (HCoV-OC43). First, primary cell cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32b7b934e509cc39ddfe3cab588a5ca
http://europepmc.org/articles/PMC7111850
http://europepmc.org/articles/PMC7111850
Autor:
Sylvain Chemtob, Hsueh-Ning Liu, Amani Khorchid, Gabriela Fragoso, Walter E. Mushynski, Guillermina Almazan, Ana Katherine Martinez-Bermudez
Publikováno v:
Journal of Neurochemistry. 90:392-404
The molecular mechanisms underlying H2O2-induced toxicity were characterized in rat oligodendrocyte cultures. While progenitor cells were more sensitive than mature oligodendrocytes to H2O2, the antioxidant, N-acetyl-l-cysteine, blocked toxicity at b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::268bbc69fcf9206cb154fd974bd62eb7
https://doi.org/10.1111/j.1471-4159.2004.02488.x
https://doi.org/10.1111/j.1471-4159.2004.02488.x
Autor:
Guillermina Almazan, Walter E. Mushynski, Janice Robertson, Gabriela Fragoso, Emily Tam, Eric S. Athlan
Publikováno v:
Experimental Neurology. 183:34-46
In the present study we demonstrate that p38, a member of the mitogen-activated protein kinase (MAPK) family, is essential for ascorbate- and laminin-induced myelination in Schwann cell-dorsal root ganglion neuron cocultures. The inhibitory effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cf8d1b2aeafbc312f5c911610cf390
https://doi.org/10.1016/s0014-4886(03)00101-8
https://doi.org/10.1016/s0014-4886(03)00101-8
Autor:
Mohammad M. Doroudchi, Minh Dang Nguyen, Jean-Pierre Julien, Michael J. Strong, Heather D. Durham, Janice Robertson, Walter E. Mushynski, Gerry Shaw
Publikováno v:
The Journal of Cell Biology
Peripherin, a neuronal intermediate filament (nIF) protein found associated with pathological aggregates in motor neurons of patients with amyotrophic lateral sclerosis (ALS) and of transgenic mice overexpressing mutant superoxide dismutase-1 (SOD1G3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec16cd8456f5306c00c53366f4abbc0
https://doi.org/10.1083/jcb.200205027
https://doi.org/10.1083/jcb.200205027