Výsledky vyhledávání - "Walter C Olson"

Akademický článek

Cancer-oocyte SAS1B protein is expressed at the cell surface of multiple solid tumors and targeted with antibody-drug conjugates

Autor: Craig L Slingluff, Walter C Olson, Christine A Tran, Arabinda Mandal, Jagathpala Shetty, Mriganka Mandal, Bhupal Ban, Eusebio S Pires, Sara J Adair, Todd W Bauer, John C Herr

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Background Sperm acrosomal SLLP1 binding (SAS1B) protein is found in oocytes, which is necessary for sperm-oocyte interaction, and also in uterine and pancreatic cancers. Anti-SAS1B antibody-drug conjugates (ADCs) arrested growth in these cancers. Ho

Externí odkaz: https://doaj.org/article/42cfd49b28e7416885b335130f1658dc

Zobrazit plný text záznamu

Akademický článek

Intratumoral IFN-γ or topical TLR7 agonist promotes infiltration of melanoma metastases by T lymphocytes expanded in the blood after cancer vaccine

Autor: Walter C Olson, Max O Meneveau, Kevin T Lynch, Christine A Tran, Priya Katyal, Craig L Slingluff,

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)

Background Immune-mediated melanoma regression relies on melanoma-reactive T cells infiltrating tumor. Cancer vaccines increase circulating melanoma-reactive T cells, but little is known about vaccine-induced circulating lymphocytes (viCLs) homing to

Externí odkaz: https://doaj.org/article/47178d74b5a14c51966fd54e06e8bc6a

Zobrazit plný text záznamu

Akademický článek

Phase I/II clinical trial of a helper peptide vaccine plus PD-1 blockade in PD-1 antibody-naïve and PD-1 antibody-experienced patients with melanoma (MEL64)

Autor: Ileana S Mauldin, Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Kelly T Smith, Nikole Varhegyi, William W Grosh, Kathleen Haden, Lynn T Dengel, Elizabeth M Gaughan, Varinder Kaur, Rick D Vavolizza

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)

Background A vaccine containing 6 melanoma-associated peptides to stimulate helper T cells (6MHP) is safe, immunogenic, and clinically active. A phase I/II trial was designed to evaluate safety and immunogenicity of 6MHP vaccines plus programmed deat

Externí odkaz: https://doaj.org/article/1a506d69a6074192a111b9cc4c3d7259

Zobrazit plný text záznamu

Akademický článek

Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freund’s adjuvant (IFA) for resected high-risk melanoma

Autor: Patrick Hwu, Jason Roszik, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Kelly T Smith, Nikole Varhegyi, Elizabeth Gaughan, Mark Smolkin, Sacha Gnjatic, Nolan A Wages, Emily H Hall, Kathleen Haden, Sapna P Patel

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)

Background We performed a clinical trial to evaluate safety and immunogenicity of a novel long peptide vaccine administered in combinations of incomplete Freund’s adjuvant (IFA) and agonists for TLR3 (polyICLC) and TLR7/8 (resiquimod). We hypothesi

Externí odkaz: https://doaj.org/article/51b27bff54f64a76a32d944873fe4395

Zobrazit plný text záznamu

Akademický článek

Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist

Autor: Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)

Background Experimental cancer vaccines are traditionally administered by injection in subcutaneous tissue or muscle, commonly with adjuvants that create chronic inflammatory depots. Injection of melanoma-derived peptides induces T cell responses; ho

Externí odkaz: https://doaj.org/article/f51a03367fd14cc38bf39a029258d603

Zobrazit plný text záznamu

Akademický článek

A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer

Autor: Patrick M. Dillon, Gina R. Petroni, Mark E. Smolkin, David R. Brenin, Kimberly A. Chianese-Bullock, Kelly T. Smith, Walter C. Olson, Ibrahim S. Fanous, Carmel J. Nail, Christiana M. Brenin, Emily H. Hall, Craig L. Slingluff

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-10 (2017)

Abstract Background Breast cancer remains a leading cause of cancer death worldwide. There is evidence that immunotherapy may play a role in the eradication of residual disease. Peptide vaccines for immunotherapy are capable of durable immune memory,

Externí odkaz: https://doaj.org/article/6b7cf945a9c4403e807ea3f6e96728ea

Zobrazit plný text záznamu

Akademický článek

Vaccine-draining lymph nodes of cancer patients for generating anti-cancer antibodies

Autor: Girja S. Shukla, Walter C. Olson, Stephanie C. Pero, Yu-jing Sun, Chelsea L. Carman, Craig L. Slingluff, David N. Krag

Publikováno v: Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-9 (2017)

Abstract Background Our research is focused on using the vaccine draining lymph node to better understand the immune response to cancer vaccines and as a possible source of anti-cancer reagents. We evaluated vaccine draining lymph nodes archived from

Externí odkaz: https://doaj.org/article/94d536027ee0417ba05e947db001f987

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání