Calcitonin gene-related peptide (CGRP) receptors are important to maintain cerebrovascular reactivity in chronic hypertension.

Autor: Zhenghui Wang, Belén Cantó Martorell, Thomas Wälchli, Olga Vogel, Jan Fischer, Walter Born, Johannes Vogel

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123697 (2015)

Cerebral blood flow autoregulation (CA) shifts to higher blood pressures in chronic hypertensive patients, which increases their risk for brain damage. Although cerebral vascular smooth muscle cells express the potent vasodilatatory peptides calciton

Externí odkaz: https://doaj.org/article/24c37a73cc4b46e1b8ca14cf99398db2

Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells

Autor: Matthias J. E. Arlt, Ingo J. Banke, Josefine Bertz, Ram Mohan Ram Kumar, Roman Muff, Walter Born, Bruno Fuchs

Publikováno v: Sarcoma, Vol 2013 (2013)

Metastasis is the major cause of death of osteosarcoma patients and its diagnosis remains difficult. In preclinical studies, however, forced expression of reporter genes in osteosarcoma cells has remarkably improved the detection of micrometastases a

Externí odkaz: https://doaj.org/article/0dc6adbe00ab4292bdcfb66563759988

Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice.

Autor: Patrick Brennecke, Matthias J E Arlt, Roman Muff, Carmen Campanile, Ana Gvozdenovic, Knut Husmann, Nathalie Holzwarth, Elisabetta Cameroni, Felix Ehrensperger, Marcus Thelen, Walter Born, Bruno Fuchs

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74045 (2013)

More effective treatment of metastasizing osteosarcoma with a current mean 5-year survival rate of less than 20% requires more detailed knowledge on mechanisms and key regulatory molecules of the complex metastatic process. CXCR4, the receptor of the

Externí odkaz: https://doaj.org/article/2ed866bc26c84ca29cb72225614364d9

Inhibition of the activin receptor signaling pathway: A novel intervention against osteosarcoma

Autor: Daniela Meier, Giovanni Pellegrini, Ana Gvozdenovic, Olga Neklyudova, Sander M. Botter, Marco Eijken, Bruno Fuchs, Walter Born, Andreas Lodberg

Publikováno v: Cancer Medicine
Meier, D, Lodberg, A, Gvozdenovic, A, Pellegrini, G, Neklyudova, O, Born, W, Fuchs, B, Eijken, M & M Botter, S 2021, ' Inhibition of the activin receptor signaling pathway : A novel intervention against osteosarcoma ', Cancer Medicine, vol. 10, no. 1 . https://doi.org/10.1002/cam4.3581

Osteosarcoma is a cancer of pathological bone remodeling with high mortality and severe comorbidity. New therapies are urgently needed. Activin A, a member of the transforming growth factor β (TGFβ) superfamily, has been suggested to stimulate prol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837b36b28e49b7325af22e835a8ee56f
https://pubmed.ncbi.nlm.nih.gov/33179858

P4475Vasodilation- and blood pressure normalization-independent cardioprotective effects of endogenous, physical activity-induced alpha calcitonin gene-related peptide in chronic hypertension

Autor: Johannes Vogel, Tom Skaria, Jan A. Fischer, Katharyn J Mitchell, Walter Born, Max Gassmann

Publikováno v: European Heart Journal. 40

Background Alpha calcitonin gene-related peptide (αCGRP) is one of the strongest vasodilators and, as such, is cardioprotective in chronic hypertension when reducing the associated elevated blood pressure. However, we hypothesize that endogenous, ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c150443add0b7bb164822abea90bc87
https://doi.org/10.1093/eurheartj/ehz745.0870