Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Walter A Koltun"'
Autor:
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin T Johnson, Xuexin Zhang, Ping Xin, Ryan E Yoast, Scott M Emrich, Gregory S Yochum, Israel Sekler, Walter A Koltun, Donald L Gill, Nadine Hempel, Mohamed Trebak
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/bacfc4e9fb7f4dd8bf3716d520a39baf
Autor:
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin T Johnson, Xuexin Zhang, Ping Xin, Ryan E Yoast, Scott M Emrich, Gregory S Yochum, Israel Sekler, Walter A Koltun, Donald L Gill, Nadine Hempel, Mohamed Trebak
Publikováno v:
eLife, Vol 9 (2020)
Despite the established role of mitochondria in cancer, the mechanisms by which mitochondrial Ca2+ (mtCa2+) regulates tumorigenesis remain incompletely understood. The crucial role of mtCa2+ in tumorigenesis is highlighted by altered expression of pr
Externí odkaz:
https://doaj.org/article/5281232761db416a876d72cbe79942a1
Autor:
Eugene Gonzalez-Lopez, Yuka Kawasawa-Imamura, Lijun Zhang, Xuemei Huang, Walter A Koltun, Matthew D Coates, Kent E Vrana
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0210175 (2019)
Inflammatory bowel diseases (IBD) are associated with altered neuronal regulation of the gastrointestinal (GI) tract and release of norepinephrine (NE). As sympathetic innervation of the GI tract modulates motility, blood flow, and immune function, c
Externí odkaz:
https://doaj.org/article/f95bfc4fb9664126969af3339a66ad80
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212850 (2019)
Crohn's disease (CD) is a debilitating inflammatory bowel disease (IBD) that arises from chronic inflammation in the gastrointestinal tract. Genome-wide association studies (GWAS) have identified over 200 single nucleotide polymorphisms (SNPs) that a
Externí odkaz:
https://doaj.org/article/ec3bc7ec53624938b2cc9a5c5966c243
Autor:
Kathleen M Schieffer, Shannon M Bruffy, Richard Rauscher, Walter A Koltun, Gregory S Yochum, Carla J Gallagher
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179267 (2017)
Chronic inflammation associated with inflammatory bowel disease (IBD) results in increased oxidative stress that damages the colonic microenvironment. Low levels of serum bilirubin, an endogenous antioxidant, have been associated with increased risk
Externí odkaz:
https://doaj.org/article/01cc88c63ed54d18b5c0e203141785c3
Autor:
Wei Yu, John P Hegarty, Arthur Berg, Xi Chen, Gail West, Ashley A Kelly, Yunhua Wang, Lisa S Poritz, Walter A Koltun, Zhenwu Lin
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20454 (2011)
BACKGROUND: NKX2-3 is associated with inflammatory bowel disease (IBD). NKX2-3 is expressed in microvascular endothelial cells and the muscularis mucosa of the gastrointestinal tract. Human intestinal microvascular endothelial cells (HIMECs) are acti
Externí odkaz:
https://doaj.org/article/585a119ec804442c9b15dafef409e73b
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11384 (2010)
BACKGROUND: Epistasis, i.e., the interaction of alleles at different loci, is thought to play a central role in the formation and progression of complex diseases. The complexity of disease expression should arise from a complex network of epistatic i
Externí odkaz:
https://doaj.org/article/5b60b1584a8347cc88d158c94253f280
Autor:
Austin C. Portolese, Brittney N. McMullen, Samantha K. Baker, Jeremy R. Chen See, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, Nimalan A. Jeganathan
Publikováno v:
Diseases of the Colon & Rectum. 66:707-715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4937cd56a6857e7eafe58ce484fa29
https://doi.org/10.1097/dcr.0000000000002647
https://doi.org/10.1097/dcr.0000000000002647
Autor:
Xiaojing Zhao, Wenjing Yang, Tianming Yu, Yu Yu, Xiufang Cui, Zheng Zhou, Hui Yang, Yanbo Yu, Anthony J. Bilotta, Suxia Yao, Jimin Xu, Jia Zhou, Gregory S. Yochum, Walter A. Koltun, Austin Portolese, Defu Zeng, Jingwu Xie, Iryna V. Pinchuk, Hongjie Zhang, Yingzi Cong
Publikováno v:
Gastroenterology. 164:89-102
Intestinal fibrosis is a significant complication of Crohn's disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not completely understood.In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922b87aadd2a20d695dfa91e332d6a61
https://doi.org/10.1053/j.gastro.2022.09.006
https://doi.org/10.1053/j.gastro.2022.09.006
Publikováno v:
Genes
Volume 14
Issue 2
Pages: 481
Volume 14
Issue 2
Pages: 481
Mutations in components of the Wnt/β-catenin signaling pathway drive colorectal cancer (CRC), in part, by deregulating expression of genes controlled by the T-cell factor (TCF) family of transcription factors. TCFs contain a conserved DNA binding do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ac5c84a1e54349cb11f833aa393ab5