Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Walter, Sandtner"'
Autor:
Johann Wachlmayr, Gotthold Fläschner, Kristyna Pluhackova, Walter Sandtner, Christine Siligan, Andreas Horner
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Facilitated water permeation through narrow biological channels is fundamental for all forms of life. Despite its significance in health and disease as well as for biotechnological applications, the energetics of water permeation are still e
Externí odkaz:
https://doaj.org/article/58834cc3d0d643a488440cbf9abebe69
Autor:
Jacqueline D. Keighron, Jordi Bonaventura, Yang Li, Jae-Won Yang, Emily M. DeMarco, Melinda Hersey, Jianjing Cao, Walter Sandtner, Michael Michaelides, Harald H. Sitte, Amy Hauck Newman, Gianluigi Tanda
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly different effects on behavior, neurochemistry, and potential f
Externí odkaz:
https://doaj.org/article/b76b51eca73a4f0bb45544c468f3d7ee
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ba79e8bedcae4f0387bc6666e032cf80
Autor:
Shreyas Bhat, Ali El-Kasaby, Ameya Kasture, Danila Boytsov, Julian B Reichelt, Thomas Hummel, Sonja Sucic, Christian Pifl, Michael Freissmuth, Walter Sandtner
Publikováno v:
eLife, Vol 12 (2023)
The serotonin transporter (SERT/SLC6A4) is arguably the most extensively studied solute carrier (SLC). During its eponymous action – that is, the retrieval of serotonin from the extracellular space – SERT undergoes a conformational cycle. Typical
Externí odkaz:
https://doaj.org/article/d660e60a78894cab8fad7e09803cb5ba
Cooperative Binding of Substrate and Ions Drives Forward Cycling of the Human Creatine Transporter-1
Autor:
Clemens V. Farr, Ali El-Kasaby, Fatma A. Erdem, Sonja Sucic, Michael Freissmuth, Walter Sandtner
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Creatine serves as an ATP buffer and is thus an integral component of cellular energy metabolism. Most cells maintain their creatine levels via uptake by the creatine transporter (CRT-1, SLC6A8). The activity of CRT-1, therefore, is a major determina
Externí odkaz:
https://doaj.org/article/ff70056a6ab347a1b8d283f6f512f111
Autor:
Thomas Barta, Walter Sandtner, Johann Wachlmayr, Christof Hannesschlaeger, Andrea Ebert, Armin Speletz, Andreas Horner
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The reconstitution of secondary active transporters into liposomes shed light on their molecular transport mechanism. The latter are either symporters, antiporters or exchangers, which use the energy contained in the electrochemical gradient of ions
Externí odkaz:
https://doaj.org/article/d26860ce12304738a2f4f5b20bbc02ca
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The diversity in solute carriers arose from evolutionary pressure. Here, we surmised that the adaptive search for optimizing the rate of substrate translocation was also shaped by the ambient extracellular and intracellular concentrations of substrat
Externí odkaz:
https://doaj.org/article/411c5ccc99f9405184b2d7d2896dff15
Autor:
Shreyas Bhat, Marco Niello, Klaus Schicker, Christian Pifl, Harald H Sitte, Michael Freissmuth, Walter Sandtner
Publikováno v:
eLife, Vol 10 (2021)
The concentrative power of the transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT) is thought to be fueled by the transmembrane Na+ gradient, but it is conceivable that they can also tap other energy sources, for example, memb
Externí odkaz:
https://doaj.org/article/f8319784533d4212a5b854d4f27eef80
Autor:
Rong Zhu, Walter Sandtner, Joan E. A. Ahiable, Amy Hauck Newman, Michael Freissmuth, Harald H. Sitte, Peter Hinterdorfer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Crystal structures and experiments relying on the tools of molecular pharmacology reported conflicting results on ligand binding sites in neurotransmitter/sodium symporters (NSS). We explored the number and functionality of ligand binding sites of NS
Externí odkaz:
https://doaj.org/article/95ac77fdd666425a8a1e581ea6e6e3df
Autor:
Felix P Mayer, Marco Niello, Daniela Cintulova, Spyridon Sideromenos, Julian Maier, Yang Li, Simon Bulling, Oliver Kudlacek, Klaus Schicker, Hideki Iwamoto, Fei Deng, Jinxia Wang, Marion Holy, Rani Katamish, Walter Sandtner, Yulong Li, Daniela Pollak, Randy D Blakely, Marko Mihovilovic, Michael H Baumann, Harald H Sitte
Publikováno v:
Molecular Psychiatry. 28:722-732
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g. social phobias and post-traumatic stress disorder. Recent evidence from preclinical and clinical studies establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c71a4ad59fd788f694b999cd4f4ca2
https://doi.org/10.1038/s41380-022-01843-w
https://doi.org/10.1038/s41380-022-01843-w