Zobrazeno 1 - 10
of 785
pro vyhledávání: '"Walter, Kolch"'
Autor:
Helena C. Bartels, Sodiq Hameed, Constance Young, Myriam Nabhan, Paul Downey, Kathleen M. Curran, Janet McCormack, Aurelie Fabre, Walter Kolch, Vadim Zhernovkov, Donal J. Brennan
Publikováno v:
npj Women's Health, Vol 2, Iss 1, Pp 1-9 (2024)
Abstract Placenta Accreta Spectrum (PAS) and pre-eclampsia are obstetric disorders associated with significant maternal morbidity and mortality. As pre-eclampsia is characterised by shallow placental invasion and PAS by abnormally deep invasion, we s
Externí odkaz:
https://doaj.org/article/1b137a68beec4c83b97d9f8a9c00b698
Autor:
Thomas Sevrin, Hiroaki Imoto, Sarah Robertson, Nora Rauch, Uscinnia Dyn’ko, Katerina Koubova, Kieran Wynne, Walter Kolch, Oleksii S. Rukhlenko, Boris N. Kholodenko
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114710- (2024)
Summary: Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges for targeted clinical interventions due to prevalent KRAS mutations, rendering PDAC resistant to RAF and MEK inhibitors (RAFi and MEKi). In addition, responses to target
Externí odkaz:
https://doaj.org/article/39fabf61047040f1b4f5fd2075684e2e
Autor:
Muhammad Zainul Arifin, Judith Leitner, Donagh Egan, Petra Waidhofer-Söllner, Walter Kolch, Vadim Zhernovkov, Peter Steinberger
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110253- (2024)
Summary: T cell co-inhibitory immune checkpoints, such as PD-1 or BTLA, are bona fide targets in cancer therapy. We used a human T cell reporter line to measure transcriptomic changes mediated by PD-1- and BTLA-induced signaling. T cell receptor (TCR
Externí odkaz:
https://doaj.org/article/24f43445e1764a898d9365d2dce13cee
Autor:
Thomas Schwarzl, Andrea Keogh, Georgina Shaw, Aleksandar Krstic, Elizabeth Clayton, Desmond G. Higgins, Walter Kolch, Frank Barry
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-6 (2023)
Abstract Articular cartilage has only very limited regenerative capacities in humans. Tissue engineering techniques for cartilage damage repair are limited in the production of hyaline cartilage. Mesenchymal stem/stromal cells (MSCs) are multipotent
Externí odkaz:
https://doaj.org/article/7c94cce76ce645939115b06e167c47f5
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 747 (2024)
In order to understand the coordinated proteome changes associated with differentiation of a cultured cell pluripotency model, protein expression changes induced by treatment of NT2 embryonal carcinoma cells with retinoic acid were monitored by mass
Externí odkaz:
https://doaj.org/article/18a1f16e0c134eb48ae8c597c159e343
Autor:
Oleksii S. Rukhlenko, Hiroaki Imoto, Ayush Tambde, Amy McGillycuddy, Philipp Junk, Anna Tuliakova, Walter Kolch, Boris N. Kholodenko
Publikováno v:
Cancers, Vol 16, Iss 13, p 2354 (2024)
Understanding signaling patterns of transformation and controlling cell phenotypes is a challenge of current biology. Here we applied a cell State Transition Assessment and Regulation (cSTAR) approach to a perturbation dataset of single cell phosphop
Externí odkaz:
https://doaj.org/article/d3292665221b414ca32fc48f6c87128e
Autor:
Mary O’Reilly, Aleksandar Krstic, Luis F. Iglesias-Martinez, Éanna J. Ryan, Bruce Moran, Des Winter, Kieran Sheahan, Ray McDermott, Walter Kolch
Publikováno v:
Journal of Personalized Medicine, Vol 14, Iss 6, p 639 (2024)
Early-onset colorectal cancer (EOCRC), defined as colorectal cancer in individuals under 50 years of age, has shown an alarming increase in incidence worldwide. We report a case of a twenty-four-year-old female with a strong family history of colorec
Externí odkaz:
https://doaj.org/article/a3ef6a494cbc45ac8d1769223a2f6c7a
Autor:
Luis F. Iglesias-Martinez, Nora Rauch, Kieran Wynne, Brendan McCann, Walter Kolch, Jens Rauch
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-10 (2023)
Abstract RAF kinases play major roles in cancer. BRAFV600E mutants drive ~6% of human cancers. Potent kinase inhibitors exist but show variable effects in different cancer types, sometimes even inducing paradoxical RAF kinase activation. Both paradox
Externí odkaz:
https://doaj.org/article/174de170ac37421395df2764af41e8b7
Autor:
Jane Howard, Kieran Wynne, Evelin Moldenhauer, Paul Clarke, Ciaran Maguire, Stephanie Bollard, Xiaofei Yin, Lorraine Brennan, Louise Mooney, Stephen Fitzsimons, Melinda Halasz, Ester Rani Aluri, Dermot F. Brougham, Walter Kolch, Róisín M. Dwyer, Shirley Potter, Pamela Kelly, Amanda McCann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Extracellular vesicles (EVs) are nanoparticles found in all biological fluids, capable of transporting biological material around the body. Extensive research into the physiological role of EVs has led to the development of the Minimal Infor
Externí odkaz:
https://doaj.org/article/c9e800f758e34614b1191fee2abdfb15
Publikováno v:
Cancers, Vol 15, Iss 16, p 4141 (2023)
RAS proteins are key regulators of cell signalling and control different cell functions including cell proliferation, differentiation, and cell death. Point mutations in the genes of this family are common, particularly in KRAS. These mutations were
Externí odkaz:
https://doaj.org/article/11d761a8e36c4b76ac20ffc4ac6ef66e