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Akademický článek

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

Autor: Carles Lerin, Allison B. Goldfine, Tanner Boes, Manway Liu, Simon Kasif, Jonathan M. Dreyfuss, Ana Luisa De Sousa-Coelho, Grace Daher, Irini Manoli, Justin R. Sysol, Elvira Isganaitis, Niels Jessen, Laurie J. Goodyear, Kirk Beebe, Walt Gall, Charles P. Venditti, Mary-Elizabeth Patti

Publikováno v: Molecular Metabolism, Vol 5, Iss 10, Pp 926-936 (2016)

Objective: Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin resistance and T2D remains u

Externí odkaz: https://doaj.org/article/4be0d7d9bd0947dc91ff7cebd1442b54

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Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

Autor: Jonathan M. Dreyfuss, Manway Liu, Niels Jessen, Walt Gall, Tanner Boes, Irini Manoli, Elvira Isganaitis, Carles Lerin, Grace Daher, Simon Kasif, Kirk Beebe, Mary-Elizabeth Patti, Charles P. Venditti, Justin R. Sysol, Ana Luísa De Sousa-Coelho, Allison B. Goldfine, Laurie J. Goodyear

Publikováno v: Molecular Metabolism
Lerin, C, Goldfine, A B, Boes, T, Liu, M, Kasif, S, Dreyfuss, J M, De Sousa-Coelho, A L, Daher, G, Manoli, I, Sysol, J R, Isganaitis, E, Jessen, N, Goodyear, L J, Beebe, K, Gall, W, Venditti, C P & Patti, M-E 2016, ' Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism ', Molecular Metabolism, vol. 5, no. 10, pp. 926-36 . https://doi.org/10.1016/j.molmet.2016.08.001
Molecular Metabolism, Vol 5, Iss 10, Pp 926-936 (2016)

Objective Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role of BCAA in the pathogenesis of insulin resistance and T2D remains un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc01faf6a8e4a27095788fc331045f9
http://europepmc.org/articles/PMC5034611

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Attenuated Effects of Bile Acids on Glucose Metabolism and Insulin Sensitivity in a Male Mouse Model of Prenatal Undernutrition

Autor: Nicholas W. Griffin, Huijuan Ma, Vicencia Sales, Yusuke Adachi, Tucker J Matthews, Wim Kulik, Jeffrey I. Gordon, Mary-Elizabeth Patti, Elvira Isganaitis, Sathish Subramanian, Michael Chen, Walt Gall, Ashley R. Wolf, Aparna Sharma, David E. Cohen

Publikováno v: Endocrinology, 158(8), 2441-2452. The Endocrine Society

Prenatal undernutrition and low birth weight are associated with risk of type 2 diabetes and obesity. Prenatal caloric restriction results in low birth weight, glucose intolerance, obesity, and reduced plasma bile acids (BAs) in offspring mice. Becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bbaadf771a5de64a0712306bc6bbb9
https://europepmc.org/articles/PMC5551557/

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Cognitive Machine-Learning Algorithm for Cardiac Imaging

Autor: Manish Bansal, Ali Ashrafi, Walt Gall, Yen-Min Huang, Partho P. Sengupta, Joel T. Dudley, Khader Shameer, Matt Fisher

Publikováno v: Circulation: Cardiovascular Imaging. 9

Background— Associating a patient’s profile with the memories of prototypical patients built through previous repeat clinical experience is a key process in clinical judgment. We hypothesized that a similar process using a cognitive computing too

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3fa92a535fa70cd9e59f22ed91e4c1
https://doi.org/10.1161/circimaging.115.004330

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Associations of cord blood metabolites with early childhood obesity risk

Autor: Jonathan M. Dreyfuss, Sheryl L. Rifas-Shiman, Elvira Isganaitis, Emily Oken, Mary-Elizabeth Patti, Matthew W. Gillman, Walt Gall

Publikováno v: International journal of obesity (2005)

Rapid postnatal weight gain is a potentially modifiable risk factor for obesity and metabolic syndrome. To identify markers of rapid infancy weight gain and childhood obesity, we analyzed the metabolome in cord blood from infants differing in their p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4041fdd6e34f8914374ad2d8c3769413
https://pubmed.ncbi.nlm.nih.gov/25804930

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Dietary betaine supplementation increases Fgf21 levels to improve glucose homeostasis and reduce hepatic lipid accumulation in mice

Autor: Jason K. Kim, Alba Gonzalez-Franquesa, Silvia Ribo, Robert E. Gerszten, Valeria De Nigris, Elizabeth Li, Mary-Elizabeth Patti, Walt Gall, Laura Martínez-Guinó, A. Ahsan Ejaz, Jonathan M. Dreyfuss, Francesc Ribas-Aulinas, Allison B. Goldfine, Teodoro Bottiglieri, Francesc Villarroya, Carles Lerin, Pablo M. Garcia-Roves

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Diabetes
Dipòsit Digital de la UB
Universidad de Barcelona

Identifying markers of human insulin resistance may permit development of new approaches for treatment and prevention of type 2 diabetes. To this end, we analyzed the fasting plasma metabolome in metabolically characterized human volunteers across a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d52cbd1033329c7c654d64a9fe73f29
http://hdl.handle.net/2445/135141

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