Highly efficient platelet generation in lung vasculature reproduced by microfluidics

Autor: Zhao, Xiaojuan, Alibhai, Dominic, Walsh, Tony G, Tarassova, Nathalie, Englert, Maximilian, Birol, Semra Z, Li, Yong, Williams, Christopher M, Neal, Chris R, Burkard, Philipp, Cross, Stephen J, Aitken, Elizabeth W, Waller, Amie K, Beltrán, José Ballester, Gunning, Peter W, Hardeman, Edna C, Agbani, Ejaife O, Nieswandt, Bernhard, Hers, Ingeborg, Ghevaert, Cedric, Poole, Alastair W

Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear. Outside the body, however, our ability to generate large number o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::6989eb5ddc74d14e9cea3c269611e3d4
https://www.repository.cam.ac.uk/handle/1810/353746

Small GTPases in platelet membrane trafficking.

Autor: Walsh, Tony G.¹, Li, Yong¹, Wersäll, Andreas¹, Poole, Alastair W.¹

Publikováno v: Platelets. Jan2019, Vol. 30 Issue 1, p31-40. 10p.

Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets

Autor: Walsh, Tony G., Wersäll, Andreas, Poole, Alastair W.

Publikováno v: Walsh, T G, Wersäll, A & Poole, A W 2019, ' Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets ', Cellular Signalling, vol. 59, pp. 34-40 . https://doi.org/10.1016/j.cellsig.2019.03.015

The Ral GTPases, RalA and RalB, have been implicated in numerous cellular processes, but are most widely known for having regulatory roles in exocytosis. Recently, we demonstrated that deletion of both Ral genes in a platelet-specific mouse gene knoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::a234eef34d9952eaf73bf3f60cd53487
https://research-information.bris.ac.uk/ws/files/191160068/1_s2.0_S0898656819300580_main.pdf

Do platelets promote cardiac recovery after myocardial infarction:Roles beyond occlusive ischemic damage

Autor: Walsh, Tony G., Poole, Alastair W.

Publikováno v: Walsh, T G & Poole, A W 2018, ' Do platelets promote cardiac recovery after myocardial infarction : Roles beyond occlusive ischemic damage ', AJP-Heart and Circulatory Physiology, vol. 314, no. 5, pp. H1043-H1048 . https://doi.org/10.1152/ajpheart.00134.2018

Our understanding of platelet function has traditionally focused on their roles in physiological hemostasis and pathological thrombosis, with the latter being causative of vessel occlusion and subsequent ischemic damage to various tissues. In particu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::48642ae34ac021f3f035dcbb996d367c
https://research-information.bris.ac.uk/ws/files/159893180/DOPLATELETS.pdf

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