Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Walraj S. Gosal"'
Autor:
Jens Füllgrabe, Walraj S. Gosal, Páidí Creed, Sidong Liu, Casper K. Lumby, David J. Morley, Tobias W. B. Ost, Albert J. Vilella, Shirong Yu, Helen Bignell, Philippa Burns, Tom Charlesworth, Beiyuan Fu, Howerd Fordham, Nicolas J. Harding, Olga Gandelman, Paula Golder, Christopher Hodson, Mengjie Li, Marjana Lila, Yang Liu, Joanne Mason, Jason Mellad, Jack M. Monahan, Oliver Nentwich, Alexandra Palmer, Michael Steward, Minna Taipale, Audrey Vandomme, Rita Santo San-Bento, Ankita Singhal, Julia Vivian, Natalia Wójtowicz, Nathan Williams, Nicolas J. Walker, Nicola C. H. Wong, Gary N. Yalloway, Joanna D. Holbrook, Shankar Balasubramanian
Publikováno v:
Nature Biotechnology.
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology. Most DNA sequencing approaches address either genetics or epigenetics and thus capture incomplete information. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8005a9ad5fe3c2a23faf8b6338fb23
https://doi.org/10.1038/s41587-022-01652-0
https://doi.org/10.1038/s41587-022-01652-0
Autor:
Jens Füllgrabe, Walraj S Gosal, Páidí Creed, Sidong Liu, Casper K Lumby, David J Morley, Tobias W B Ost, Albert J Vilella, Shirong Yu, Helen Bignell, Philippa Burns, Tom Charlesworth, Beiyuan Fu, Howerd Fordham, Nick Harding, Olga Gandelman, Paula Golder, Christopher Hodson, Mengjie Li, Marjana Lila, Yang Liu, Joanne Mason, Jason Mellad, Jack Monahan, Oliver Nentwich, Alexandra Palmer, Michael Steward, Minna Taipale, Audrey Vandomme, Rita Santo San-Bento, Ankita Singhal, Julia Vivian, Natalia Wójtowicz, Nathan Williams, Nicolas J Walker, Nicola C H Wong, Gary Yalloway, Joanna D Holbrook, Shankar Balasubaramanian
DNA comprises molecular information stored via genetic bases (G, C, T, A) and also epigenetic bases, principally 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Both genetic and epigenetic information are vital to our understanding of biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac2af7acf13559572475f1c21b6cbf27
https://doi.org/10.1101/2022.07.08.499285
https://doi.org/10.1101/2022.07.08.499285
Autor:
Fabio Puddu, Casper K. Lumby, Nick Harding, David J. Morley, Jamie Scotcher, Robert Crawford, Jens Füllgrabe, Walraj S. Gosal, Shirong Yu, Daniel Brudzewsky, Jane Haywood, Andrada Tomoni, Philippa Burns, Joanna D. Holbrook, Paidi Creed
Publikováno v:
Cancer Research. 83:6602-6602
Liquid biopsy for profiling of cell free DNA (cfDNA) in blood holds huge promise to transform how we experience and manage cancer by early detection and identification of residual disease and subtype. However, a standard blood draw yields an average
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f4fa5e12c44cd2ab268ab0a366036b6
https://doi.org/10.1158/1538-7445.am2023-6602
https://doi.org/10.1158/1538-7445.am2023-6602
Autor:
Sheena E. Radford, Walraj S. Gosal, Andrew L. Hellewell, Eric W. Hewitt, Wei-Feng Xue, Steve W. Homans
Publikováno v:
The Journal of Biological Chemistry
Fibrils associated with amyloid disease are molecular assemblies of key biological importance, yet how cells respond to the presence of amyloid remains unclear. Cellular responses may not only depend on the chemical composition or molecular propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc1ff03f2f42a3db64e17fe06bc765e
http://europepmc.org/articles/PMC2797196
http://europepmc.org/articles/PMC2797196
Autor:
Helen E. White, Elena V. Orlova, Shirley A. Müller, Thomas R. Jahn, Sheena E. Radford, Sara Cohen-Krausz, Julie L. Hodgkinson, Walraj S. Gosal, Helen R. Saibil
Publikováno v:
Journal of Molecular Biology
Amyloid fibrils are ordered polymers in which constituent polypeptides adopt a non-native fold. Despite their importance in degenerative human diseases, the overall structure of amyloid fibrils remains unknown. High-resolution studies of model peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b3308efed7f3fb18312b6bc2806c23
Publikováno v:
Journal of Biological Chemistry. 282:29691-29700
Dialysis related amyloidosis is a serious complication of long-term hemodialysis in which beta(2)-microglobulin (beta(2)m) forms amyloid fibrils that deposit predominantly in cartilaginous tissues. How these fibrils form in vivo, however, is poorly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b41cc13aa7afd87c2cd4d921a39a20a
https://doi.org/10.1074/jbc.m705004200
https://doi.org/10.1074/jbc.m705004200
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1753:51-63
Deriving a complete understanding of protein self-association into amyloid fibrils across multiple distance and time scales is an enormous challenge. At small length scales, a detailed description of the partially folded protein ensemble that partici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113a44959e1b6e77e8b22826a74c88a9
https://doi.org/10.1016/j.bbapap.2005.07.006
https://doi.org/10.1016/j.bbapap.2005.07.006
Publikováno v:
Biomacromolecules. 5:2430-2438
Oscillatory shear rheometry has been used to study the gelation of beta-lactoglobulin at ambient in 50% v/v trifluoroethanol (TFE)/pH 7 aqueous buffer and in 50% v/v ethanol (EtOH)/water at pH 2. In contrast to what was found on heating aqueous solut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef27988bd208814089242afe6e3bb9a8
https://doi.org/10.1021/bm0496615
https://doi.org/10.1021/bm0496615
Publikováno v:
Langmuir. 18:7174-7181
Biology provides us with a unique set of self-assembled fibrillar networks in the form of amyloid fibrils, derived from the self-assembly of a number of peptides or misfolded proteins. These, in turn, are associated with a number of diseases such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b5e298407d0e1be949a28179b682d86
https://doi.org/10.1021/la025531a
https://doi.org/10.1021/la025531a
Publikováno v:
Macromolecules. 33:7029-7037
Mixed globular protein gels, or gel composites, based on heating solutions of proteins from milk have been investigated for many years, although the great majority of these studies have used rather crude whey isolates containing a fixed ratio of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66ddf1718d58ada798f7cd2002a421f6
https://doi.org/10.1021/ma0005522
https://doi.org/10.1021/ma0005522