Zobrazeno 1 - 10 of 246 pro vyhledávání: '"Wallis NG"'
1
Akademický článek
Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase.
Autor: Palmer N; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Agnew C; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Benn C; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Buffham WJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Castro JN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Chessari G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Clark M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Cons BD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Coyle JE; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Dawson LA; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hamlett CCF; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hodson C; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Holding F; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Johnson CN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Liebeschuetz JW; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Mahajan P; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., McCarthy JM; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Murray CW; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., O'Reilly M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Peakman T; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Price A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Rapti M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Reeks J; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Schöpf P; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., St-Denis JD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Valenzano C; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wallis NG; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Walser R; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Weir H; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wilsher NE; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Woodhead A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Bento CF; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Tisi D; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11168-11181. Date of Electronic Publication: 2024 Jun 27.
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2
Akademický článek
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
Autor: Day JEH; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Berdini V; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Castro J; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Chessari G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Davies TG; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Day PJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., St Denis JD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Fujiwara H; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Fukaya S; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Hamlett CCF; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hearn K; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hiscock SD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Holvey RS; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Ito S; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Kandola N; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Kodama Y; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Liebeschuetz JW; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Martins V; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Matsuo K; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Mortenson PN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Muench S; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Nakatsuru Y; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Ochiiwa H; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Palmer N; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Peakman T; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Price A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Reader M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Rees DC; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Rich SJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Shah A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Shibata Y; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Smyth T; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Twigg DG; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wallis NG; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Williams G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wilsher NE; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Woodhead A; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Shimamura T; Taiho Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan., Johnson CN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4655-4675. Date of Electronic Publication: 2024 Mar 10.
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3
Akademický článek
ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK.
Autor: Munck JM; Astex Pharmaceuticals, Cambridge, United Kingdom. nicola.wallis@astx.com joanne.munck@astx.com., Berdini V; Astex Pharmaceuticals, Cambridge, United Kingdom., Bevan L; Astex Pharmaceuticals, Cambridge, United Kingdom., Brothwood JL; Astex Pharmaceuticals, Cambridge, United Kingdom., Castro J; Astex Pharmaceuticals, Cambridge, United Kingdom., Courtin A; Astex Pharmaceuticals, Cambridge, United Kingdom., East C; Astex Pharmaceuticals, Cambridge, United Kingdom., Ferraldeschi R; Astex Pharmaceuticals, Cambridge, United Kingdom., Heightman TD; Astex Pharmaceuticals, Cambridge, United Kingdom., Hindley CJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Kucia-Tran J; Astex Pharmaceuticals, Cambridge, United Kingdom., Lyons JF; Astex Pharmaceuticals, Cambridge, United Kingdom., Martins V; Astex Pharmaceuticals, Cambridge, United Kingdom., Muench S; Astex Pharmaceuticals, Cambridge, United Kingdom., Murray CW; Astex Pharmaceuticals, Cambridge, United Kingdom., Norton D; Astex Pharmaceuticals, Cambridge, United Kingdom., O'Reilly M; Astex Pharmaceuticals, Cambridge, United Kingdom., Reader M; Astex Pharmaceuticals, Cambridge, United Kingdom., Rees DC; Astex Pharmaceuticals, Cambridge, United Kingdom., Rich SJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Richardson CJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Shah AD; Astex Pharmaceuticals, Cambridge, United Kingdom., Stanczuk L; Astex Pharmaceuticals, Cambridge, United Kingdom., Thompson NT; Astex Pharmaceuticals, Cambridge, United Kingdom., Wilsher NE; Astex Pharmaceuticals, Cambridge, United Kingdom., Woolford AJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Wallis NG; Astex Pharmaceuticals, Cambridge, United Kingdom. nicola.wallis@astx.com joanne.munck@astx.com.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Oct; Vol. 20 (10), pp. 1757-1768. Date of Electronic Publication: 2021 Jul 30.
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4
Akademický článek
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Autor: Heightman TD; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Berdini V; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Bevan L; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Buck IM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Carr MG; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Courtin A; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Coyle JE; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Day JEH; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., East C; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Fazal L; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Griffiths-Jones CM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Howard S; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Kucia-Tran J; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Martins V; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Muench S; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Munck JM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Norton D; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., O'Reilly M; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Palmer N; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Pathuri P; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Peakman TM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Reader M; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Rees DC; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Rich SJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Shah A; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Wallis NG; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Walton H; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Wilsher NE; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Woolford AJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Cooke M; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Cousin D; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Onions S; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Shannon J; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Watts J; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K., Murray CW; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Aug 26; Vol. 64 (16), pp. 12286-12303. Date of Electronic Publication: 2021 Aug 13.
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5
Akademický článek
ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.
Autor: Ward GA; Astex Pharmaceuticals, Cambridge, United Kingdom. George.ward@astx.com., Lewis EJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Ahn JS; Astex Pharmaceuticals, Cambridge, United Kingdom., Johnson CN; Astex Pharmaceuticals, Cambridge, United Kingdom., Lyons JF; Astex Pharmaceuticals, Cambridge, United Kingdom., Martins V; Astex Pharmaceuticals, Cambridge, United Kingdom., Munck JM; Astex Pharmaceuticals, Cambridge, United Kingdom., Rich SJ; Astex Pharmaceuticals, Cambridge, United Kingdom., Smyth T; Astex Pharmaceuticals, Cambridge, United Kingdom., Thompson NT; Astex Pharmaceuticals, Cambridge, United Kingdom., Williams PA; Astex Pharmaceuticals, Cambridge, United Kingdom., Wilsher NE; Astex Pharmaceuticals, Cambridge, United Kingdom., Wallis NG; Astex Pharmaceuticals, Cambridge, United Kingdom., Chessari G; Astex Pharmaceuticals, Cambridge, United Kingdom.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2018 Jul; Vol. 17 (7), pp. 1381-1391. Date of Electronic Publication: 2018 Apr 25.
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6
Akademický článek
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Autor: Heightman TD; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Berdini V; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Braithwaite H; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Buck IM; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Cassidy M; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Castro J; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Courtin A; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Day JEH; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., East C; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Fazal L; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Graham B; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Griffiths-Jones CM; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Lyons JF; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Martins V; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Muench S; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Munck JM; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Norton D; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., O'Reilly M; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Palmer N; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Pathuri P; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Reader M; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Rees DC; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Rich SJ; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Richardson C; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Saini H; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Thompson NT; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Wallis NG; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Walton H; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Wilsher NE; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Woolford AJ; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K., Cooke M; Sygnature Discovery Ltd., BioCity , Pennyfoot Street , Nottingham , NG1 1GF , U.K., Cousin D; Sygnature Discovery Ltd., BioCity , Pennyfoot Street , Nottingham , NG1 1GF , U.K., Onions S; Sygnature Discovery Ltd., BioCity , Pennyfoot Street , Nottingham , NG1 1GF , U.K., Shannon J; Sygnature Discovery Ltd., BioCity , Pennyfoot Street , Nottingham , NG1 1GF , U.K., Watts J; Sygnature Discovery Ltd., BioCity , Pennyfoot Street , Nottingham , NG1 1GF , U.K., Murray CW; Astex Pharmaceuticals , 436 Cambridge Science Park , Cambridge , CB4 0QA , U.K.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jun 14; Vol. 61 (11), pp. 4978-4992. Date of Electronic Publication: 2018 May 31.
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7
Akademický článek
BioisoIdentifier: an online free tool to investigate local structural replacements from PDB.
Autor: Zhang, Tinghao1 (AUTHOR), Sun, Shaohua1 (AUTHOR), Wang, Runzhou2 (AUTHOR), Li, Ting1 (AUTHOR), Gan, Bicheng3 (AUTHOR), Zhang, Yuezhou1,4 (AUTHOR) iamyzzhang@nwpu.edu.cn
Publikováno v: Journal of Cheminformatics. 1/13/2024, Vol. 16 Issue 1, p1-17. 17p.
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8
Akademický článek
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10
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