Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure.

Autor: Feio-Azevedo R; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Boesch M; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Radenkovic S; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Metabolomics Expertise Center, Center for Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, Metabolomics Expertise Center, KU Leuven, Leuven, Belgium.; Department of Clinical Genomics, Mayo Clinic, Rochester, Minnesota, USA., van Melkebeke L; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Smets L; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Wallays M; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Boeckx B; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, Leuven, Belgium., Philips G; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, Leuven, Belgium., Prata de Oliveira J; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Ghorbani M; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Laleman W; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Meersseman P; Department of Internal Medicine, UZ Leuven, KU Leuven, Leuven, Belgium., Wilmer A; Department of Internal Medicine, UZ Leuven, KU Leuven, Leuven, Belgium., Cassiman D; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Metabolomics Expertise Center, Center for Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., van Malenstein H; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Triantafyllou E; Section of Hepatology and Gastroenterology, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Sánchez C; European Foundation for the Study of Chronic Liver Failure, EF-CLIF, EASL-CLIF Consortium and Grifols Chair, Barcelona, Spain., Aguilar F; European Foundation for the Study of Chronic Liver Failure, EF-CLIF, EASL-CLIF Consortium and Grifols Chair, Barcelona, Spain., Nevens F; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Verbeek J; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Moreau R; European Foundation for the Study of Chronic Liver Failure, EF-CLIF, EASL-CLIF Consortium and Grifols Chair, Barcelona, Spain.; Centre de Recherche sur l'Inflammation (CRI) UMRS1149, Université de Paris Cité, Service d'Hépatologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France., Arroyo V; European Foundation for the Study of Chronic Liver Failure, EF-CLIF, EASL-CLIF Consortium and Grifols Chair, Barcelona, Spain., Denadai Souza A; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Clària J; European Foundation for the Study of Chronic Liver Failure, EF-CLIF, EASL-CLIF Consortium and Grifols Chair, Barcelona, Spain.; Hospital Clínic-IDIBAPS, CIBERehd, Universitat de Barcelona, Barcelona, Spain., Lambrechts D; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.; VIB Center for Cancer Biology, Leuven, Belgium., Ghesquière B; Metabolomics Expertise Center, Center for Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, Metabolomics Expertise Center, KU Leuven, Leuven, Belgium., Korf H; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., van der Merwe S; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium.; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2024 May 16. Date of Electronic Publication: 2024 May 16.

Adipose tissue macrophage dysfunction is associated with a breach of vascular integrity in NASH.

Autor: Boesch M; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Lindhorst A; Institute of Anatomy, Leipzig University, Leipzig, Germany., Feio-Azevedo R; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Brescia P; IRCCS Humanitas Research Hospital, Manzoni 56, 20089 Rozzano, Milan, Italy., Silvestri A; IRCCS Humanitas Research Hospital, Manzoni 56, 20089 Rozzano, Milan, Italy., Lannoo M; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Deleus E; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Jaekers J; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Topal H; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Topal B; Department of Abdominal Surgery, UZ Leuven, Leuven, Belgium., Ostyn T; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, 3000 Leuven, Belgium., Wallays M; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Smets L; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium., Van Melkebeke L; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Härtlova A; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Roskams T; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, 3000 Leuven, Belgium., Bedossa P; Department of Pathology, Physiology and Imaging, Beaujon Hospital Paris Diderot University, Paris, France., Verbeek J; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium., Govaere O; Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, 3000 Leuven, Belgium., Francque S; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium; Translational Research in Inflammation and Immunology (TWI2N), Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., Sifrim A; KU Leuven Institute for Single Cell Omics (LISCO), 3000 Leuven, Belgium; Laboratory of Multi-omic Integrative Bioinformatics, Center for Human Genetics, KU Leuven, 3000 Leuven, Belgium., Voet T; KU Leuven Institute for Single Cell Omics (LISCO), 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Rescigno M; IRCCS Humanitas Research Hospital, Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, 20072 Pieve Emanuele, Milan, Italy., Gericke M; Institute of Anatomy, Leipzig University, Leipzig, Germany., Korf H; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium. Electronic address: hannelie.korf@kuleuven.be., van der Merwe S; Laboratory of Hepatology, CHROMETA Department, KU Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium. Electronic address: schalk.vandermerwe@uzleuven.be.

Publikováno v: Journal of hepatology [J Hepatol] 2024 Mar; Vol. 80 (3), pp. 397-408. Date of Electronic Publication: 2023 Nov 15.

Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction.

Autor: Adant I; Laboratory of Hepatology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, 3000, Belgium; Metabolomics Expertise Center, Center for Cancer Biology, CCB-VIB, VIB, Leuven, 3000, Belgium., Bird M; Laboratory of Hepatology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, 3000, Belgium; Metabolomics Expertise Center, Center for Cancer Biology, CCB-VIB, VIB, Leuven, 3000, Belgium; Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, 3000, Belgium., Decru B; Laboratory of Hepatology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, 3000, Belgium; Metabolomics Expertise Center, Center for Cancer Biology, CCB-VIB, VIB, Leuven, 3000, Belgium., Windmolders P; Laboratory of Hepatology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, 3000, Belgium., Wallays M; Laboratory of Hepatology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, 3000, Belgium., de Witte P; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium., Rymen D; Metabolic Centre, University Hospitals Leuven, Leuven, 3000, Belgium., Witters P; Metabolic Centre, University Hospitals Leuven, Leuven, 3000, Belgium., Vermeersch P; Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, 3000, Belgium; Department of Cardiovascular Sciences, KU Leuven, Leuven, 3000, Belgium., Cassiman D; Laboratory of Hepatology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, 3000, Belgium; Metabolic Centre, University Hospitals Leuven, Leuven, 3000, Belgium. Electronic address: david.cassiman@kuleuven.be., Ghesquière B; Metabolomics Expertise Center, Center for Cancer Biology, CCB-VIB, VIB, Leuven, 3000, Belgium; Metabolomics Expertise Center, Department of Oncology, KU Leuven, Leuven, 3000, Belgium. Electronic address: bart.ghesquiere@kuleuven.be.

Publikováno v: Molecular metabolism [Mol Metab] 2022 Sep; Vol. 63, pp. 101537. Date of Electronic Publication: 2022 Jun 27.

Protective Effect of Uridine on Structural and Functional Rearrangements in Heart Mitochondria after a High-Dose Isoprenaline Exposure Modelling Stress-Induced Cardiomyopathy in Rats.

Autor: Belosludtseva, Natalia V.¹ (AUTHOR) belosludtsevanv@iteb.pushchino.ru, Pavlik, Lubov L.¹ (AUTHOR) mikheirina@yandex.ru, Mikheeva, Irina B.¹ (AUTHOR) evg-talanov@yandex.ru, Talanov, Eugeny Yu.¹ (AUTHOR) bekonik@gmail.com, Serov, Dmitriy A.² (AUTHOR) dmitriy_serov_91@mail.ru, Khurtin, Dmitriy A.³ (AUTHOR) dimaxur11@mail.ru, Belosludtsev, Konstantin N.^1,3 (AUTHOR), Mironova, Galina D.¹ (AUTHOR) belosludtsevanv@iteb.pushchino.ru

Publikováno v: International Journal of Molecular Sciences. Dec2023, Vol. 24 Issue 24, p17300. 21p.

Uridine Inhibits Hepatocellular Carcinoma Cell Development by Inducing Ferroptosis.

Autor: Zi, Liuliu^1,2 (AUTHOR), Ma, Wangbin¹ (AUTHOR), Zhang, Lilong¹ (AUTHOR), Qiao, Boyang³ (AUTHOR), Qiu, Zhendong¹ (AUTHOR), Xu, Junhui¹ (AUTHOR), Zhang, Jiacheng¹ (AUTHOR), Ye, Yahong⁴ (AUTHOR), Yang, Yueyuan⁴ (AUTHOR), Dong, Keshuai¹ (AUTHOR), Chen, Chen¹ (AUTHOR), Wang, Weixing¹ (AUTHOR) sate.llite@163.com, Zhao, Qingyan² (AUTHOR) sate.llite@163.com

Publikováno v: Journal of Clinical Medicine. May2023, Vol. 12 Issue 10, p3552. 14p.