Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wallace W. Bradford"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:4269-4278
Aberrant or deregulated activity of certain cellular kinases has been shown to cause certain malignancies and other disorders. The tyrphostin molecule AG490 inhibits the action of the janus kinases JAK2 and JAK3. JAK2 is an indispensable molecule for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05722346f55c7548de96623b0aeb89bc
https://doi.org/10.1016/j.bmc.2005.04.022
https://doi.org/10.1016/j.bmc.2005.04.022
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 56:461-463
The antitrypanosomal agent K777•HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease. The radiolabeled compound was prepared in eight st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b410b25d499d6ecbbe2543de52cc42
https://doi.org/10.1002/jlcr.3107
https://doi.org/10.1002/jlcr.3107
Publikováno v:
Journal of Heterocyclic Chemistry. 40:569-573
The syntheses of the potential heterocyclic amine food mutagens l,4,6-trimethyl-2-aminoimidazo[4,5-c]-pyridine and 1,5,7-trimethyl-2-aminoimidazo[4,5-b]pyridine are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d772974f41aa04ffcef97b908d96f9
https://doi.org/10.1002/jhet.5570400403
https://doi.org/10.1002/jhet.5570400403
Autor:
Lalitha V. Iyer, Mark Nguyen Ho, Wallace W. Bradford, Walter Shinn, Shirley S. Nath, Mary J. Tanga, Carol E. Green
Publikováno v:
Toxicological Sciences. 73:36-43
Estragole (4-allyl-1-methoxybenzene) is a naturally occurring food flavoring agent found in basil, fennel, bay leaves, and other spices. Estragole and its metabolite, 1'-hydroxyestragole (1'-HE), are hepatocarcinogens in rodent models. Recent studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d997f4be5fea84e2a6fc0468b66f9a85
https://doi.org/10.1093/toxsci/kfg066
https://doi.org/10.1093/toxsci/kfg066
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:405-411
The syntheses of the deuterium-labeled food mutagen 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine (PhIP) and its N-hydroxy metabolite are described. Unlabeled PhIP is deuterated using a boron trifluoride phosphoric acid complex in one step. Lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::248ee0a6013f6d1b6c36cfaed8ad9ce4
https://doi.org/10.1002/jlcr.468
https://doi.org/10.1002/jlcr.468
Autor:
Beatrice Ruhland-Fritsch, Robert W. Sidwell, John H. Huffman, Priscilla A. Sturm, Elmer J. Reist, Nurulain T. Zaveri, Wallace W. Bradford
Publikováno v:
Nucleosides and Nucleotides. 13:539-550
Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine, and guinea pig strains of cytomegalovirus. The phosphonates showed high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e97b2965aa11d0ec161c43116c3c067
https://doi.org/10.1080/15257779408013261
https://doi.org/10.1080/15257779408013261
Autor:
Robert W. Sidwell, John H. Huffman, Wallace W. Bradford, Priscilla A. Sturm, Beatrice Ruhland-Fritsch, Elmer J. Reist, Nurulain T. Zaveri
Publikováno v:
ChemInform. 26
Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine, and guinea pig strains of cytomegalovirus. The phosphonates showed high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21b481b6dd724078c2668c355f4d5df6
https://doi.org/10.1002/chin.199502192
https://doi.org/10.1002/chin.199502192
Autor:
Wallace W. Bradford, Anna M. Furimsky, Izet M. Kapetanovic, Shirley S. Brill, Yi Li, Lalitha V. Iyer, Michael J. Furniss, Adam G. Green, Carol E. Green, Mark Nguyen Ho
Publikováno v:
The Journal of pharmacy and pharmacology. 58(4)
Resveratrol (trans-resveratrol, trans-3,5,4′-trihydroxystilbene) is a naturally occurring stilbene analogue found in high concentrations in red wine. There is considerable research interest to determine the therapeutic potential of resveratrol, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876786b3b6a6d5699c1bbc8f9590fc84
https://pubmed.ncbi.nlm.nih.gov/16597364
https://pubmed.ncbi.nlm.nih.gov/16597364
Autor:
Shirley S. Brill, Anna M. Furimsky, Mark N. Ho, Michael J. Furniss, Yi Li, Adam G. Green, Wallace W. Bradford, Carol E. Green, Izet M. Kapetanovic, Lalitha V. Iyer
Publikováno v:
Journal of Pharmacy & Pharmacology; Apr2006, Vol. 58 Issue 4, p469-479, 11p
Publikováno v:
Journal of Labelled Compounds & Radiopharmaceuticals; Sep1981, Vol. 18 Issue 9, p1261-1272, 12p