Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Wallace L Akerley"'
Autor:
Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Oncolytic virus V937 showed activity and safety with intratumoral administration. This phase 1 study evaluated intravenous V937±pembrolizumab in patients with advanced solid tumors.Methods Patients had advanced non-small cell lung cancer
Externí odkaz:
https://doaj.org/article/07dff5f507bc4d64bce5f819f24c264d
Autor:
Michael E Goldberg, Meagan Montesion, Lauren Young, James Suh, Joel Greenbowe, Mark Kennedy, Giuseppe Giaccone, Wallace L Akerley, Afshin Dowlati, Benjamin C Creelan, James K Hicks, Paul J Hesketh, Karen L Kelly, Jonathan W Riess, Vincent A Miller, Philip J Stephens, Garrett M Frampton, Siraj Ali, Jeffrey P Gregg, Lee A Albacker
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0208097 (2018)
After sequential treatment with first- and third-generation EGFR tyrosine kinase inhibitors (TKIs), EGFR-mutant non-small cell lung cancers frequently harbor multiple resistance mutations in exon 20 of EGFR including T790M, mediating resistance to fi
Externí odkaz:
https://doaj.org/article/648ec5a7f1f64da7a4f700ccb8ad9657
Autor:
Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy, Douglas W. Sborov, Paul J. Shami
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patients with advanced soli
Externí odkaz:
https://doaj.org/article/1960d709654346b28eb07dc1080b90ac
Autor:
James Chih-Hsin Yang, MD, PhD, Karen L. Reckamp, MD, Young-Chul Kim, MD, PhD, Silvia Novello, MD, PhD, Egbert F. Smit, MD, PhD, Jong-Seok Lee, MD, PhD, Wu-Chou Su, MD, Wallace L. Akerley, MD, Collin M. Blakely, MD, PhD, Harry J.M. Groen, MD, PhD, Lyudmila Bazhenova, MD, Enric Carcereny Costa, MD, Rita Chiari, MD, PhD, Te-Chun Hsia, MD, PhD, Tony Golsorkhi, MD, Darrin Despain, MStat, Danny Shih, BA, Sanjay Popat, BSc, MBBS, FRCP, PhD, Heather Wakelee, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 2, Pp 100114- (2021)
Introduction: The TIGER-3 (NCT02322281) study was initiated to compare the efficacy and safety of rociletinib, a third-generation EGFR tyrosine kinase inhibitor (TKI) that targets EGFR T790M and common EGFR-activating mutations, versus chemotherapy i
Externí odkaz:
https://doaj.org/article/3960fcdf0ad54bcf8d21572f501bc5e5
Autor:
Benjamin B. Morris, Nolan A. Wages, Patrick A. Grant, P. Todd Stukenberg, Ryan D. Gentzler, Richard D. Hall, Wallace L. Akerley, Thomas K. Varghese, Susanne M. Arnold, Terence M. Williams, Vincenzo Coppola, David R. Jones, David T. Auble, Marty W. Mayo
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
It has long been recognized that defects in cell cycle checkpoint and DNA repair pathways give rise to genomic instability, tumor heterogeneity, and metastasis. Despite this knowledge, the transcription factor-mediated gene expression programs that e
Externí odkaz:
https://doaj.org/article/1a759e60bfaf402dba58cabda12ab76f
Autor:
Shirish M. Gadgeel, Jieling Miao, Jonathan W. Riess, James Moon, Philip C. Mack, Gregory J. Gerstner, Timothy F. Burns, Asma Taj, Wallace L. Akerley, Konstantin H. Dragnev, Noel Laudi, Mary W. Redman, Jhanelle E. Gray, David R. Gandara, Karen Kelly
Publikováno v:
Clinical Cancer Research.
Purpose: Efficacy of MEK inhibitors in KRAS+ NSCLC may differ based on specific KRAS mutations and co-mutations. Our hypothesis was that docetaxel and trametinib would improve activity in KRAS+ NSCLC and specifically in KRAS G12C NSCLC. Patients and
Autor:
Caroline Himbert, Cassandra A. Hathaway, Bailee Daniels, Karen Salas, Anjelica Ashworth, Biljana Gigic, Tengda Lin, Richard Viskochil, Anne C. Kirchhoff, Douglas Grossman, Jennifer Ose, Jonathan Tward, Courtney Scaife, Jane C. Figueiredo, Adetunji T. Toriola, Anna Beck, David Shibata, Brian D. Gonzalez, Cindy Matsen, Cristina Christenson, Debra S. Ma, Howard Colman, Jason P. Hunt, Kevin B. Jones, Catherine J. Lee, Mikaela Larson, Tracy Onega, Wallace L. Akerley, Christopher I. Li, Martin Schneider, Frank J. Penedo, Erin M. Siegel, Shelley S. Tworoger, Cornelia M. Ulrich, Anita R. Peoples
Publikováno v:
Cancer Causes & Control. 33:939-950
There is limited information on how the COVID-19 pandemic has changed health behaviors among cancer patients. We examined changes in exercise behaviors since the pandemic and identified characteristics associated with these changes among cancer patie
Autor:
Benjamin B. Morris, Jason P. Smith, Qi Zhang, Zhijie Jiang, Oliver A. Hampton, Michelle L. Churchman, Susanne M. Arnold, Dwight H. Owen, Jhanelle E. Gray, Patrick M. Dillon, Hatem H. Soliman, Daniel G. Stover, Howard Colman, Arnab Chakravarti, Kenneth H. Shain, Ariosto S. Silva, John L. Villano, Michael A. Vogelbaum, Virginia F. Borges, Wallace L. Akerley, Ryan D. Gentzler, Richard D. Hall, Cindy B. Matsen, C. M. Ulrich, Andrew R. Post, David A. Nix, Eric A. Singer, James M. Larner, Peter Todd Stukenberg, David R. Jones, Marty W. Mayo
Publikováno v:
Biomolecules; Volume 12; Issue 11; Pages: 1570
In the past decade, defective DNA repair has been increasingly linked with cancer progression. Human tumors with markers of defective DNA repair and increased replication stress exhibit genomic instability and poor survival rates across tumor types.
Autor:
Anita R. Peoples, Laura B. Oswald, Jennifer Ose, Bailee Daniels, Caroline Himbert, Cassandra A. Hathaway, Biljana Gigic, Anne C. Kirchhoff, Tengda Lin, Douglas Grossman, Jonathan Tward, Thomas K. Varghese, Jane C. Figueiredo, Adetunji T. Toriola, Anna Beck, Courtney Scaife, David Shibata, Paul LaStayo, Brian Gonzalez, Karen Salas, Anjelica Ashworth, Cindy Matsen, Cristina Christenson, Debra S. Ma, Howard Colman, Jason P. Hunt, Kevin B. Jones, Catherine J. Lee, Mikaela Larson, Tracy Onega, Wallace L. Akerley, Christopher I. Li, Martin Schneider, Frank J. Penedo, Erin M. Siegel, Shelley S. Tworoger, Cornelia M. Ulrich
Publikováno v:
The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association. 38(4)
The COVID-19 pandemic has disrupted many facets of life. We evaluated pandemic-related health care experiences, COVID-19 prevention behaviors and measures, health behaviors, and psychosocial outcomes among rural and urban cancer patients.Among 1,472
Autor:
Charles M Rudin, Hardev S Pandha, Matthew Zibelman, Wallace L Akerley, Kevin J Harrington, Daphne Day, Andrew G Hill, Steven J O'Day, Timothy D Clay, Gavin M Wright, Ross R Jennens, David E Gerber, Jonathan E Rosenberg, Christy Ralph, David C Campbell, Brendan D Curti, Jaime R Merchan, Yixin Ren, Emmett V Schmidt, Lisa Guttman, Sumati Gupta
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e005007
BackgroundOncolytic virus V937 showed activity and safety with intratumoral administration. This phase 1 study evaluated intravenous V937±pembrolizumab in patients with advanced solid tumors.MethodsPatients had advanced non-small cell lung cancer (N