Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Wallace K B, Chan"'
Autor:
Josh N. Vo, Yi-Mi Wu, Jeanmarie Mishler, Sarah Hall, Rahul Mannan, Lisha Wang, Yu Ning, Jin Zhou, Alexander C. Hopkins, James C. Estill, Wallace K. B. Chan, Jennifer Yesil, Xuhong Cao, Arvind Rao, Alexander Tsodikov, Moshe Talpaz, Craig E. Cole, Jing C. Ye, Multiple Myeloma Research Consortium, P. Leif Bergsagel, Daniel Auclair, Hearn Jay Cho, Dan R. Robinson, Arul M. Chinnaiyan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The genetic factors involved in disease progression and drug resistance in multiple myeloma (MM) are varied and complex. Here, genomic and transcriptomic profiling of 511 relapsed and refractory MM patients reveals genetic alterations in several onco
Externí odkaz:
https://doaj.org/article/f655f451b78e4e7097fa8cd313e2e43d
Autor:
Wallace K. B. Chan, Keith M. Olson, Jesse W. Wotring, Jonathan Z. Sexton, Heather A. Carlson, John R. Traynor
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires treatments with rapid clinical translatability. Here we develop a multi-target and multi-ligand virtual screening method to identify FDA-app
Externí odkaz:
https://doaj.org/article/9d0a26fd74654609ba21d5d036893487
Autor:
Yingtong Liu, Junguk Hur, Wallace K. B. Chan, Zhigang Wang, Jiangan Xie, Duxin Sun, Samuel Handelman, Jonathan Sexton, Hong Yu, Yongqun He
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-12 (2021)
Abstract Our systematic literature collection and annotation identified 106 chemical drugs and 31 antibodies effective against the infection of at least one human coronavirus (including SARS-CoV, SAR-CoV-2, and MERS-CoV) in vitro or in vivo in an exp
Externí odkaz:
https://doaj.org/article/f088e050f20c4123afa354dfa35d4e8c
Publikováno v:
J Chem Inf Model
In this study, we target the main protease (M(pro)) of the SARS-CoV-2 virus as it is a crucial enzyme for viral replication. Herein, we report three plausible allosteric sites on M(pro) that can expand structure-based drug discovery efforts for new M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607f6176275397b1bee62d95218571a4
https://doi.org/10.1021/acs.jcim.1c01223
https://doi.org/10.1021/acs.jcim.1c01223
Autor:
Vicky P, Chen, Roy C Y, Choi, Wallace K B, Chan, K Wing, Leung, Ava J Y, Guo, Gallant K L, Chan, Wilson K W, Luk, Karl W K, Tsim
Publikováno v:
The Journal of biological chemistry. 286(38)
Acetylcholinesterase (AChE) anchors onto cell membranes by a transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric form in vertebrate brain. The assembly of AChE tetramer with PRiMA requires the C-terminal "t-peptide" in AChE cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::499c52c75096c065ebabf528bc90bd0b
https://pubmed.ncbi.nlm.nih.gov/21795704
https://pubmed.ncbi.nlm.nih.gov/21795704