Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Wallace, Eli M"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Andrew S. Cowburn, Shanhai Xie, David Macías, Alexander J.T. Wood, Stephen Moore, Alexi Crosby, Xinlin Du, Wallace Eli M, Arlette Vassallo, Mark Southwood, Huiling Tan
Publikováno v:
The European Respiratory Journal
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart failure and death. Current therapeutic intervention strategies only slow disease progression. The role of aberrant hypoxia-induci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32b00f5971d07524076e05a9913a5a2
http://europepmc.org/articles/PMC7930471
http://europepmc.org/articles/PMC7930471
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Maria G. Frid, Steven C. Pugliese, Aya Laux, Amanda Flockton, Min Li, Sushil Kumar, R. Dale Brown, Kurt R. Stenmark, Suzette R. Riddle, Brittany McKeon, Wallace Eli M, Gary Mouradian, Brian B. Graham, Jens M. Poth, Hui Zhang, Cheng-Jun Hu
Most published studies addressing the role of HIFs in hypoxia-induced PH development employ models that may not recapitulate the clinical setting, including the use of animals having pre-existing lung/vascular defects secondary to embryonic HIF ablat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414f6c5c8b519a08599cc8ecce1e6e89
https://europepmc.org/articles/PMC6911916/
https://europepmc.org/articles/PMC6911916/
Autor:
Hu, Cheng-Jun, Poth, Jens M, Zhang, Hui, Flockton, Amanda, Laux, Aya, Kumar, Sushil, McKeon, Brittany, Mouradian, Gary, Li, Min, Riddle, Suzette, Pugliese, Steven C, Brown, R Dale, Wallace, Eli M, Graham, Brian B, Frid, Maria G, Stenmark, Kurt R
Publikováno v:
The European respiratory journal, vol 54, iss 6
Most published studies addressing the role of hypoxia inducible factors (HIFs) in hypoxia-induced pulmonary hypertension development employ models that may not recapitulate the clinical setting, including the use of animals with pre-existing lung/vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::c2656ab820da30f9babf634099811f81
https://escholarship.org/uc/item/43g1g36t
https://escholarship.org/uc/item/43g1g36t
Autor:
Kevin D. Courtney, James Brugarolas, Wallace Eli M, John A. Josey, Elaine T. Lam, Ann M. Lowe, Robert A. Figlin, Naseem J. Zojwalla, Brian I. Rini, Jeffrey R. Infante, Keshi Wang, Toni K. Choueiri
Publikováno v:
Journal of Clinical Oncology. 36:867-874
Purpose The von Hippel-Lindau tumor suppressor is inactivated in the majority of clear cell renal cell carcinomas (ccRCCs), leading to inappropriate stabilization of hypoxia-inducible factor-2α (HIF-2α). PT2385 is a first-in-class HIF-2α antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8fefa23e5ed18b9452f81c4caa9544
https://doi.org/10.1200/jco.2017.74.2627
https://doi.org/10.1200/jco.2017.74.2627
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Rui Xu, Wallace Eli M, Paul Wehn, Jim Rizzi, Robert M. Czerwinski, Xinlin Du, Carlos Huerta, Emily R. Morton, Deepak Nijhawan, Oleg A. Volkov, Hui Ling Tan
E7820 and indisulam are two examples of aryl sulfonamides that recruit RBM39 to Rbx-Cul4-DDA1-DDB1-DCAF15 E3 ligase complex, leading to its ubiquitination and degradation by the proteasome. In order to understand their mechanism of action, we carried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbfe8f46247b0a1e1401f631d681900
Autor:
Jim Rizzi, Robert M. Czerwinski, Xinlin Du, Hui Ling Tan, Emily R. Morton, Wallace Eli M, Carlos Huerta, Paul Wehn, Oleg A. Volkov, Deepak Nijhawan, Rui Xu
Publikováno v:
Structure (London, England : 1993). 27(11)
E7820 and indisulam are two examples of aryl sulfonamides that recruit RBM39 to Rbx-Cul4-DDA1-DDB1-DCAF15 E3 ligase complex, leading to its ubiquitination and degradation by the proteasome. To understand their mechanism of action, we performed kineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8be1827294dd2e1fee04195a35d55b5
https://pubmed.ncbi.nlm.nih.gov/31693911
https://pubmed.ncbi.nlm.nih.gov/31693911
Autor:
Paul Yell, Farrah Homayoun, Xiankai Sun, Ivan Pedrosa, Naseem J. Zojwalla, Tae Hyun Hwang, Andrea Pavia-Jimenez, Wallace Eli M, Tai Wong, Wenfang Chen, Allison Joyce, Nirav V. Patel, Renée M. McKay, Xian Jin Xie, James Brugarolas, Kevin D. Courtney, James P. Rizzi, Payal Kapur, Kevin H. Gardner, Eboni Holloman, Haley Hill, Min Kim, Richard K. Bruick, John A. Josey, Alana Christie, Jenny Chang, He Zhang, Eugene P. Frenkel, Yuanqing Ma, Heather Geiger, Guiyang Hao, Yang Xie, Qurratulain Yousuf, Catherine Reeves
Publikováno v:
Nature. 539:112-117
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL). Because no other gene is mutated as frequently in ccRCC and VHL mutations are truncal, VHL inactivation is regarded as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323b60296507f0be5c9fc30b0ac74a79
https://doi.org/10.1038/nature19796
https://doi.org/10.1038/nature19796