Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Walker Hoolehan"'
Autor:
Kyla B. Tooley, Ana J. Chucair-Elliott, Sarah R. Ocañas, Adeline H. Machalinski, Kevin D. Pham, Walker Hoolehan, Adam M. Kulpa, David R. Stanford, Willard M. Freeman
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-27 (2023)
Abstract Background Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neuroscience, there is a pressing need to isolate and characterize the epigenomes of specific CNS cell types in hea
Externí odkaz:
https://doaj.org/article/773d1b37618b472fabb42ce59c6c91ce
Publikováno v:
ACS Omega, Vol 8, Iss 38, Pp 34206-34214 (2023)
Externí odkaz:
https://doaj.org/article/e13171e2a91d4a79a9762a24f7af620e
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216137 (2019)
RAG2 of the V(D)J recombinase is essential for lymphocyte development. Within the RAG2 noncore region is a plant homeodomain (PHD) that interacts with the modified histone H3K4me3, and this interaction is important for relieving inhibition of the RAG
Externí odkaz:
https://doaj.org/article/2a2d99dc63b14c308a30b44ece522a6f
Publikováno v:
Nucleic acids research. 50(20)
In the adaptive immune system, V(D)J recombination initiates the production of a diverse antigen receptor repertoire in developing B and T cells. Recombination activating proteins, RAG1 and RAG2 (RAG1/2), catalyze V(D)J recombination by cleaving adja
In the adaptive immune system, V(D)J recombination initiates the production of a diverse antigen receptor repertoire in developing B and T cells. Recombination activating proteins, RAG1 and RAG2 (RAG1/2), catalyze V(D)J recombination by cleaving adja
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4415492ddc87e77526d121ec8dfcd600
https://doi.org/10.1101/2021.12.03.471157
https://doi.org/10.1101/2021.12.03.471157
Autor:
Karla K. Rodgers, Walker Hoolehan
Publikováno v:
The FASEB Journal. 35
Publikováno v:
Immunobiology
V(D)J recombination by the RAG1 and RAG2 protein complex in developing lymphocytes includes DNA double strand break (DSB) intermediates. RAG2 undergoes export from the nucleus and enrichment at the centrosome minutes following production of DSBs by g
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216137 (2019)
PLoS ONE
PLoS ONE
RAG2 of the V(D)J recombinase is essential for lymphocyte development. Within the RAG2 noncore region is a plant homeodomain (PHD) that interacts with the modified histone H3K4me3, and this interaction is important for relieving inhibition of the RAG
Publikováno v:
The Journal of Immunology. 202:53.24-53.24
RAG2 is essential for V(D)J recombination in developing lymphocytes, yet its localization and dynamics in cell nuclei is poorly understood. Here, we used single-cell imaging to interrogate RAG2 interactions with transcriptionally active chromatin con