Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Walid J Azar"'
Autor:
David S. Liu, Cuong P. Duong, Sue Haupt, Karen G. Montgomery, Colin M. House, Walid J. Azar, Helen B. Pearson, Oliver M. Fisher, Matthew Read, Glen R. Guerra, Ygal Haupt, Carleen Cullinane, Klas G. Wiman, Lars Abrahmsen, Wayne A. Phillips, Nicholas J. Clemons
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Efficient therapeutic strategies to target mutant-p53 cancers are needed. Here, the authors demonstrate the molecular mechanism through which mutant-p53 tumours are susceptible to oxidative damage and propose a potential strategy for targeting such c
Externí odkaz:
https://doaj.org/article/158fa6f4dc10458fa818d00a36bab589
Autor:
David D.L. Bowtell, Dariush Etemadmoghadam, Ronny Drapkin, Alison M. Karst, Danny Rischin, Linda Mileshkin, Richard B. Pearson, Carleen Cullinane, Diar Aziz, Kurt Lackovic, Kate E. Jarman, Chris Mitchell, Walid J. Azar, Franziska Lang, George Au-Yeung
Supplementary Table S1 - RT-PCR Primer sequences used in the study Supplementary Table S2 - CDK2 shRNA sequences used in the study Supplementary Table S3 - Cell lines and genes used in the analysis from Project Achilles Supplementary Table S4 - EC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2f3f3700ae0ac844eafb1c07c49660
https://doi.org/10.1158/1078-0432.22463450
https://doi.org/10.1158/1078-0432.22463450
Autor:
David D.L. Bowtell, George Au-Yeung, David S. Liu, Chris Mitchell, Elizabeth L. Christie, Walid J. Azar
Selected compounds for secondary screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68faefdf2e60acf62b386fa5b0faedbb
https://doi.org/10.1158/0008-5472.22424484.v1
https://doi.org/10.1158/0008-5472.22424484.v1
Autor:
Anna deFazio, David D.L. Bowtell, Ivan B. Lomakin, Helen Rizos, Martin Köbel, Sean M. Grimmond, Nicola Waddell, John V. Pearson, Timothy Semple, Timothy P. Holloway, Gisela Mir Arnau, George Au-Yeung, Joshy George, Ann-Marie Patch, Elizabeth L. Christie, Jason Li, Paul R. Harnett, Raghwa Sharma, Joy Hendley, Yoke-Eng Chiew, Chris Mitchell, Sian Fereday, Catherine J. Kennedy, Dale W. Garsed, Tania Moujaber, Ying Lei, Walid J. Azar, Dariush Etemadmoghadam
Low-grade serous ovarian carcinomas (LGSC) are associated with a poor response to chemotherapy and are molecularly characterized by RAS pathway activation. Using exome and whole genome sequencing, we identified recurrent mutations in the protein tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de61d8a9c700ed14b683350e2bb143e6
https://doi.org/10.1158/0008-5472.c.6509045.v1
https://doi.org/10.1158/0008-5472.c.6509045.v1
Autor:
David D.L. Bowtell, Dariush Etemadmoghadam, Ronny Drapkin, Alison M. Karst, Danny Rischin, Linda Mileshkin, Richard B. Pearson, Carleen Cullinane, Diar Aziz, Kurt Lackovic, Kate E. Jarman, Chris Mitchell, Walid J. Azar, Franziska Lang, George Au-Yeung
Purpose: Cyclin E1 (CCNE1) amplification is associated with primary treatment resistance and poor outcome in high-grade serous ovarian cancer (HGSC). Here, we explore approaches to target CCNE1-amplified cancers and potential strategies to overcome r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d877fd05f018f7dc70d8439c9254b02b
https://doi.org/10.1158/1078-0432.c.6525410
https://doi.org/10.1158/1078-0432.c.6525410
Autor:
Anna deFazio, David D.L. Bowtell, Ivan B. Lomakin, Helen Rizos, Martin Köbel, Sean M. Grimmond, Nicola Waddell, John V. Pearson, Timothy Semple, Timothy P. Holloway, Gisela Mir Arnau, George Au-Yeung, Joshy George, Ann-Marie Patch, Elizabeth L. Christie, Jason Li, Paul R. Harnett, Raghwa Sharma, Joy Hendley, Yoke-Eng Chiew, Chris Mitchell, Sian Fereday, Catherine J. Kennedy, Dale W. Garsed, Tania Moujaber, Ying Lei, Walid J. Azar, Dariush Etemadmoghadam
Supplemental Material - Group Authorship from EIF1AX and NRAS Mutations Co-occur and Cooperate in Low-Grade Serous Ovarian Carcinomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027e670cd644246a5a5453c1a27413c2
https://doi.org/10.1158/0008-5472.22414655.v1
https://doi.org/10.1158/0008-5472.22414655.v1
Autor:
David D.L. Bowtell, Dariush Etemadmoghadam, Ronny Drapkin, Alison M. Karst, Danny Rischin, Linda Mileshkin, Richard B. Pearson, Carleen Cullinane, Diar Aziz, Kurt Lackovic, Kate E. Jarman, Chris Mitchell, Walid J. Azar, Franziska Lang, George Au-Yeung
Supplementary Figure S1 - Validation of CCNE1 and CDK2 siRNA-mediated knockdown Supplementary Figure S2 - Validation of CDK2 knockdown mediated by shRNA in vitro and in vivo Supplementary Figure S3 - FACS plots validating incorporation and induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c273b1d104ac9fa623318e8336c6e5e
https://doi.org/10.1158/1078-0432.22463456
https://doi.org/10.1158/1078-0432.22463456