Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Walid A Houry"'
Publikováno v:
eLife, Vol 9 (2020)
The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins. ClpXP is an important target for drug development ag
Externí odkaz:
https://doaj.org/article/822beeb8932145e48d5d5f0bd6a2ecf3
Autor:
Yunchen Gong, Yoshito Kakihara, Nevan Krogan, Jack Greenblatt, Andrew Emili, Zhaolei Zhang, Walid A Houry
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-14 (2009)
Abstract Molecular chaperones are known to be involved in many cellular functions, however, a detailed and comprehensive overview of the interactions between chaperones and their cofactors and substrates is still absent. Systematic analysis of physic
Externí odkaz:
https://doaj.org/article/8d87aa59ba4449c1b58a634c8f260a95
Autor:
Pedro M Matias, Sung Hee Baek, Tiago M Bandeiras, Anindya eDutta, Walid A Houry, Oscar eLlorca, Jean eRosenbaum
Publikováno v:
Frontiers in Molecular Biosciences, Vol 2 (2015)
Pontin and Reptin are related partner proteins belonging to the AAA+ (ATPases Associated with various cellular Activities) family. They are implicated in multiple and seemingly unrelated processes encompassing the regulation of gene transcription, th
Externí odkaz:
https://doaj.org/article/164f85a3521f455d846345d56155fa6a
Autor:
Hélène Malet, Kaiyin Liu, Majida El Bakkouri, Sze Wah Samuel Chan, Gregory Effantin, Maria Bacia, Walid A Houry, Irina Gutsche
Publikováno v:
eLife, Vol 3 (2014)
Externí odkaz:
https://doaj.org/article/37c8491903b947c6abd099bf4f2f7f66
Autor:
Hélène Malet, Kaiyin Liu, Majida El Bakkouri, Sze Wah Samuel Chan, Gregory Effantin, Maria Bacia, Walid A Houry, Irina Gutsche
Publikováno v:
eLife, Vol 3 (2014)
A 3.3 MDa macromolecular cage between two Escherichia coli proteins with seemingly incompatible symmetries–the hexameric AAA+ ATPase RavA and the decameric inducible lysine decarboxylase LdcI–is reconstructed by cryo-electron microscopy to 11 Å
Externí odkaz:
https://doaj.org/article/9343808ba55947f2ad5ad1dc54e0f356
Autor:
Mohan Babu, Roland Arnold, Cedoljub Bundalovic-Torma, Alla Gagarinova, Keith S Wong, Ashwani Kumar, Geordie Stewart, Bahram Samanfar, Hiroyuki Aoki, Omar Wagih, James Vlasblom, Sadhna Phanse, Krunal Lad, Angela Yeou Hsiung Yu, Christopher Graham, Ke Jin, Eric Brown, Ashkan Golshani, Philip Kim, Gabriel Moreno-Hagelsieb, Jack Greenblatt, Walid A Houry, John Parkinson, Andrew Emili
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004120 (2014)
Large-scale proteomic analyses in Escherichia coli have documented the composition and physical relationships of multiprotein complexes, but not their functional organization into biological pathways and processes. Conversely, genetic interaction (GI
Externí odkaz:
https://doaj.org/article/2896e8427bcd49608cc1b53f2c8d503b
Autor:
Keith S Wong, Jamie D Snider, Chris Graham, Jack F Greenblatt, Andrew Emili, Mohan Babu, Walid A Houry
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85529 (2014)
MoxR ATPases are widespread throughout bacteria and archaea. The experimental evidence to date suggests that these proteins have chaperone-like roles in facilitating the maturation of dedicated protein complexes that are functionally diverse. In Esch
Externí odkaz:
https://doaj.org/article/ae9351f545f746548f586bb12b5dd786
Autor:
Makio Saeki, Hiroshi Egusa, Yuya Kamano, Yoshito Kakihara, Walid A Houry, Hirofumi Yatani, Shinzaburo Noguchi, Yoshinori Kamisaki
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67326 (2013)
Increased stabilization of mRNA coding for key cancer genes can contribute to invasiveness. This is achieved by down-regulation of exosome cofactors, which bind to 3'-UTR in cancer-related genes. Here, we identified amphiregulin, an EGFR ligand, as a
Externí odkaz:
https://doaj.org/article/355d242b07f043bb8c2d4e9358650bde
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9934 (2010)
Hsp90 is an essential molecular chaperone that is also a novel anti-cancer drug target. There is growing interest in developing new drugs that modulate Hsp90 activity.Using a virtual screening approach, 4-hydroxytamoxifen, the active metabolite of th
Externí odkaz:
https://doaj.org/article/d51dbe0b7e584f53987af0ccf4de3a0a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent de
Externí odkaz:
https://doaj.org/article/ac7886371b2f446d8ae03246789fdaac