Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Walid A, Houry"'
Autor:
Yu-Qian Mao, Thiago V. Seraphim, Yimei Wan, Ruikai Wu, Etienne Coyaud, Muhammad Bin Munim, Antonio Mollica, Estelle Laurent, Mohan Babu, Vito Mennella, Brian Raught, Walid A. Houry
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113713- (2024)
Summary: R2TP is a chaperone complex consisting of the AAA+ ATPases RUVBL1 and RUVBL2, as well as RPAP3 and PIH1D1 proteins. R2TP is responsible for the assembly of macromolecular complexes mainly acting through different adaptors. Using proximity-la
Externí odkaz:
https://doaj.org/article/7c22cf9435a24e6dad0a5388e234f529
Autor:
Larissa Machado Antonio, Gustavo Henrique Martins, Annelize Zambon Barbosa Aragão, Natália Galdi Quel, Gabriel Zazeri, Walid A. Houry, Carlos Henrique Inacio Ramos
Publikováno v:
Plants, Vol 12, Iss 16, p 2925 (2023)
The chaperone R2TP has multiple subunits that assist in the proper folding, assembly, and stabilization of various protein complexes in cells and its study can offer valuable insights into the regulation and maintenance of protein assemblies in plant
Externí odkaz:
https://doaj.org/article/d4d70b46bbf44634b395f0c8ed9536f1
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent de
Externí odkaz:
https://doaj.org/article/ac7886371b2f446d8ae03246789fdaac
Autor:
Emily M. J. Fennell, Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Andrew A. Iwanowicz, Hani Ashamalla, Ekhson Holmuhamedov, Henk Lang, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz, Lee M. Graves
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the relat
Externí odkaz:
https://doaj.org/article/d148e9686840428483903862c1681076
Autor:
Kamran Rizzolo, Angela Yeou Hsiung Yu, Adedeji Ologbenla, Sa-Rang Kim, Haojie Zhu, Koichiro Ishimori, Guillaume Thibault, Elisa Leung, Yi Wen Zhang, Mona Teng, Marta Haniszewski, Noha Miah, Sadhna Phanse, Zoran Minic, Sukyeong Lee, Julio Diaz Caballero, Mohan Babu, Francis T. F. Tsai, Tomohide Saio, Walid A. Houry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
ClpXP is the main ATP-dependent proteolytic complex in bacteria, is essential for maintaining cellular protein homeostasis and is also critical for bacterial pathogenesis. Here, the authors establish a functional link between ClpXP and trigger actor,
Externí odkaz:
https://doaj.org/article/bb669bad02bc48fc84564ad981954599
Autor:
Jeffrey Lynham, Walid A. Houry
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1045 (2022)
Hsp90 is a ubiquitous molecular chaperone involved in many cell signaling pathways, and its interactions with specific chaperones and cochaperones determines which client proteins to fold. Hsp90 has been shown to be involved in the promotion and main
Externí odkaz:
https://doaj.org/article/164f03f5a0ee49609e6c1e105364d056
Publikováno v:
eLife, Vol 9 (2020)
The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins. ClpXP is an important target for drug development ag
Externí odkaz:
https://doaj.org/article/822beeb8932145e48d5d5f0bd6a2ecf3
Autor:
Subha Dahal, Ran Cheng, Peter K. Cheung, Terek Been, Ramy Malty, Melissa Geng, Sarah Manianis, Lulzim Shkreta, Shahrazad Jahanshahi, Johanne Toutant, Rose Chan, Sean Park, Mark A. Brockman, Mohan Babu, Samira Mubareka, Karen Mossman, Arinjay Banerjee, Scott Gray-Owen, Martha Brown, Walid A. Houry, Benoit Chabot, David Grierson, Alan Cochrane
Publikováno v:
Viruses, Vol 14, Iss 1, p 60 (2021)
Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 a
Externí odkaz:
https://doaj.org/article/1c76f49ace8b4a22bb54cfbd594bd88c
Autor:
Kamran Rizzolo, Angela Yeou Hsiung Yu, Adedeji Ologbenla, Sa Rang Kim, Haojie Zhu, Koichiro Ishimori, Guillaume Thibault, Elisa Leung, Yi Wen Zhang, Mona Teng, Marta Haniszewski, Noha Miah, Sadhna Phanse, Zoran Minic, Sukyeong Lee, Julio Diaz Caballero, Mohan Babu, Francis T. F. Tsai, Tomohide Saio, Walid A. Houry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/48ed5bf4e8a048a39dcda55f24f8469f
Autor:
Kamran Rizzolo, Jennifer Huen, Ashwani Kumar, Sadhna Phanse, James Vlasblom, Yoshito Kakihara, Hussein A. Zeineddine, Zoran Minic, Jamie Snider, Wen Wang, Carles Pons, Thiago V. Seraphim, Edgar Erik Boczek, Simon Alberti, Michael Costanzo, Chad L. Myers, Igor Stagljar, Charles Boone, Mohan Babu, Walid A. Houry
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2735-2748 (2017)
A comprehensive view of molecular chaperone function in the cell was obtained through a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping. This allowed us to de
Externí odkaz:
https://doaj.org/article/f2af40acd84148669d6f31a51b5f7bd6