Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Walid, Mourad"'
Publikováno v:
Cells, Vol 13, Iss 19, p 1621 (2024)
CD154, also known as CD40 ligand, is a costimulatory molecule involved in humoral and adaptive immune responses upon pairing with its classical receptor, CD40. The CD154/CD40 dyad is a key participant in the pathogenesis of many autoimmune diseases,
Externí odkaz:
https://doaj.org/article/dba2cc506a474d07820e4d23837e8c67
Publikováno v:
Cells, Vol 11, Iss 11, p 1747 (2022)
CD154, an inflammatory mediator also known as CD40 ligand, has been identified as a novel binding partner for some members of the integrin family. The αIIbβ3, specifically expressed on platelets, was the first integrin to be described as a receptor
Externí odkaz:
https://doaj.org/article/352b03748b814e86ac3849615da86275
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 3 (2020)
Background Antiplatelet therapy with aspirin (acetylsalicylic acid [ASA]) is less efficient in some coronary patients, which increases their risk of developing thrombosis. Elevated blood levels of thromboinflammatory mediators, like soluble CD40L (sC
Externí odkaz:
https://doaj.org/article/36b22120f1eb49c9b56118a9858cce61
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235753 (2020)
CD154 plays a major role in the pathogenesis of several autoimmune and inflammatory diseases. In addition to CD40, soluble CD154 (sCD154) binds to other receptors namely αIIbβ3, αMβ2, α5β1 and αvβ3 integrins. We have previously reported that
Externí odkaz:
https://doaj.org/article/fd469f314e614640b78c59e1b62ef938
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 23 (2018)
Background CD40 ligand (CD40L) is a thromboinflammatory molecule that predicts cardiovascular events. CD40L is a strong activator of nuclear factor kappa B (NF‐κB) in platelets that primes and enhances platelet activation in response to thrombotic
Externí odkaz:
https://doaj.org/article/a178972bc3534dcf8d038a31a569e1eb
Publikováno v:
ImmunoHorizons. 5:590-601
In addition to the membrane-bound molecule, soluble CD154 (sCD154) is also detected at high levels in the medium of activated T cells and platelets and in the serum of patients suffering from different inflammatory diseases. This sCD154 is the result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a85745f34c63289a425b3025a98d583
https://doi.org/10.4049/immunohorizons.2100062
https://doi.org/10.4049/immunohorizons.2100062
Publikováno v:
The Journal of Immunology. 206:1793-1805
In addition to the membrane-bound form, CD154 also exists as a soluble molecule originating from an intracellular and membrane cleavage. We have previously shown that CD154 cleavage from T cell surface is mediated by CD40 and involves the action of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0001a36370fb64e0452601f0e5488ad
https://doi.org/10.4049/jimmunol.2001340
https://doi.org/10.4049/jimmunol.2001340
Autor:
Di Xue, Marylin Desjardins, Gabriel Nathan Kaufman, Marianne Beland, Salem Al-Tamemi, Eisha Ahmed, Shao Tao, Roland Friedel, Walid Mourad, Bruce David Mazer
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Background: Semaphorins are important molecules in embryonic development and multiple semaphorins have been identified as having key roles in immune regulation. To date, there is little known about Semaphorin 4C (Sema4C) in immune biology. We report
Externí odkaz:
https://doaj.org/article/c624cde807d84eb787191b244c67fd4d
Autor:
Meriem Bachsais, Nadim Naddaf, Daniel Yacoub, Suzanne Salti, Nada Alaaeddine, Fawzi Aoudjit, Ghada S Hassan, Walid Mourad
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158987 (2016)
CD154, a critical regulator of the immune response, is usually associated with chronic inflammatory, autoimmune diseases as well as malignant disorders. In addition to its classical receptor CD40, CD154 is capable of binding other receptors, members
Externí odkaz:
https://doaj.org/article/f62bd0ec895d460482607cf7326f0ea2
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:AB334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c8d6d491f3c4696715bf852d54b655
https://doi.org/10.1016/j.jaci.2022.12.774
https://doi.org/10.1016/j.jaci.2022.12.774