Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Waleed A. Zalloum"'
Autor:
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A. Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X. Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract HIV-1 reverse transcriptase is one of the most attractive targets for the treatment of AIDS. However, the rapid emergence of drug-resistant strains and unsatisfactory drug-like properties seriously limit the clinical application of HIV-1 non
Externí odkaz:
https://doaj.org/article/c38865deec50478fa334e921f6a1050d
Autor:
Shujing Xu, Lin Sun, Waleed A. Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Publikováno v:
Molecules, Vol 27, Iss 23, p 8415 (2022)
HIV-1 capsid (CA) performs multiple roles in the viral life cycle and is a promising target for antiviral development. In this work, we describe the design, synthesis, assessment of antiviral activity, and mechanistic investigation of 20 piperazinone
Externí odkaz:
https://doaj.org/article/08d03fb8fcbd442c925e5a2912ff863d
Autor:
Shuo Wang, Yujie Ren, Zhao Wang, Xiangyi Jiang, Shujing Xu, Xujie Zhang, Shujie Zhao, Waleed A Zalloum, Xinyong Liu, Peng Zhan
Publikováno v:
Expert Opinion on Drug Discovery. 17:1329-1340
Boron has attracted extensive interest due to several FDA-approved boron-containing drugs and other pharmacological agents in clinical trials. As a semimetal, it has peculiar biochemical characteristics which could be utilized in designing novel drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41d1a8224c9c12b5c1e1a75af60d9e0
https://doi.org/10.1080/17460441.2023.2153829
https://doi.org/10.1080/17460441.2023.2153829
Autor:
Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan, Dongwei Kang, Wenbo Wang, Xiangyi Jiang, Waleed A. Zalloum, Zhao Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:13658-13675
Enlightened by the available structural biology information, a novel series of dihydrothiopyrano[4,3-d]pyrimidine derivatives were rationally designed via scaffold hopping and molecular hybridization strategies. Notably, compound 20a yielded exceptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::821f048ccd5acba1e4a783a704f10352
https://doi.org/10.1021/acs.jmedchem.1c01015
https://doi.org/10.1021/acs.jmedchem.1c01015
Autor:
Shujing Xu, Lin Sun, Waleed A. Zalloum, Xujie Zhang, Tianguang Huang, Dang Ding, Yucen Tao, Fabao Zhao, Shenghua Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Simon Cocklin, Xinyong Liu, Peng Zhan
Publikováno v:
Chinese Chemical Letters. 34:107611
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccaf85bf26cd977f94e37acbd7346db6
https://doi.org/10.1016/j.cclet.2022.06.034
https://doi.org/10.1016/j.cclet.2022.06.034
Autor:
Zhao, Wang, Waleed A, Zalloum, Wenbo, Wang, Xiangyi, Jiang, Erik, De Clercq, Christophe, Pannecouque, Dongwei, Kang, Peng, Zhan, Xinyong, Liu
Publikováno v:
Journal of medicinal chemistry. 64(18)
Enlightened by the available structural biology information, a novel series of dihydrothiopyrano[4,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e892f18f3583c3e12973cf808ffeec3
https://pubmed.ncbi.nlm.nih.gov/34432448
https://pubmed.ncbi.nlm.nih.gov/34432448
Autor:
Needa Zalloum, Waleed A. Zalloum
Publikováno v:
The journal of physical chemistry. B. 125(20)
Targeting the genetic material without destruction is a priority to develop safe anticancer drugs. Histone deacetylase 8 (HDAC8), which is proved to be involved in carcinogenesis, is an enzyme associated with the chromatin for post-translational deac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b714d26c63118c394c60391a55f813a
https://pubmed.ncbi.nlm.nih.gov/33998791
https://pubmed.ncbi.nlm.nih.gov/33998791
Autor:
Tao Zhang, Peng Zhan, Xinyong Liu, Waleed A. Zalloum, Fenju Wei, Dongwei Kang, Srinivasulu Cherukupalli
Publikováno v:
Expert opinion on therapeutic patents. 30(9)
Hepatitis B disease is caused by the hepatitis B virus (HBV), which is a DNA virus that belongs to the Hepadnaviridae family. It is a considerable health burden, with 257 million active cases globally. Long-standing infection may create a fundamental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b6cfd1641d832758cdba6a4bcf6cbe
https://pubmed.ncbi.nlm.nih.gov/32746660
https://pubmed.ncbi.nlm.nih.gov/32746660
Autor:
Srinivasulu Cherukupalli, Xiao Ding, Chin Ho Chen, Kuo Hsiung Lee, Simon Cocklin, Alexej Dick, Dongwei Kang, Ping Gao, Lin Sun, Megan E. Meuser, Peng Zhan, Waleed A. Zalloum, Shujing Xu, Tianguang Huang, Xinyong Liu, Christophe Pannecouque, Erik De Clercq
Publikováno v:
J Med Chem
The HIV-1 CA protein has gained remarkable attention as a promising therapeutic target for the development of new antivirals, due to its pivotal roles in HIV-1 replication (structural and regulatory). Herein, we report the design and synthesis of thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2781e3b2b8f910c3ef736a6003330040
https://lirias.kuleuven.be/handle/123456789/685205
https://lirias.kuleuven.be/handle/123456789/685205
Autor:
Ruifang Jia, Xiangyi Jiang, Dongwei Kang, Gaochan Wu, Waleed A. Zalloum, Peng Zhan, Megan E. Meuser, Lanlan Jing, Lin Sun, Chin Ho Chen, Simon Cocklin, Alexej Dick, Xinyong Liu, Kuo Hsiung Lee
Publikováno v:
RSC advances. 9(50)
The HIV-1 capsid (CA) protein plays crucial roles in both early and late stages of the viral life cycle, which has intrigued researchers to target it to develop anti-HIV drugs. Accordingly, in this research, we report the design, synthesis and biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aafcd987782d7f54b3e83b79c3ae253
https://pubmed.ncbi.nlm.nih.gov/32089839
https://pubmed.ncbi.nlm.nih.gov/32089839