Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

Autor: Walden E. Bjørn-Yoshimoto, Iris Bea L. Ramiro, Mark Yandell, J. Michael McIntosh, Baldomero M. Olivera, Lars Ellgaard, Helena Safavi-Hemami

Publikováno v: Biomedicines, Vol 8, Iss 8, p 235 (2020)

Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous measurable scientific and societal benefits. These include their use as a drug, diagnostic agen

Externí odkaz: https://doaj.org/article/6b041b87910c47ceb84a03c9b8ff1f53

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

Autor: Iris Bea L. Ramiro, Walden E. Bjørn-Yoshimoto, Julita S. Imperial, Joanna Gajewiak, Paula Flórez Salcedo, Maren Watkins, Dylan Taylor, William Resager, Beatrix Ueberheide, Hans Bräuner-Osborne, Frank G. Whitby, Christopher P. Hill, Laurent F. Martin, Amol Patwardhan, Gisela P. Concepcion, Baldomero M. Olivera, Helena Safavi-Hemami

Publikováno v: Ramiro, I B L, Bjørn-Yoshimoto, W E, Imperial, J S, Gajewiak, J, Salcedo, P F, Watkins, M, Taylor, D, Resager, W, Ueberheide, B, Bräuner-Osborne, H, Whitby, F G, Hill, C P, Martin, L F, Patwardhan, A, Concepcion, G P, Olivera, B M & Safavi-Hemami, H 2022, ' Somatostatin venom analogs evolved by fish-hunting cone snails : From prey capture behavior to identifying drug leads ', Science Advances, vol. 8, no. 12, eabk1410 . https://doi.org/10.1126/sciadv.abk1410

Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f9e07a144d167f897f9d586fca1be9
https://pubmed.ncbi.nlm.nih.gov/35319982

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

Autor: Baldomero M. Olivera, Iris Bea L Ramiro, Walden E. Bjørn-Yoshimoto, Joanna Gajewiak, Laurent F. Martin, Hans Bräuner-Osborne, Christopher P. Hill, Gisela P. Concepcion, Amol M. Patwardhan, Beatrix Ueberheide, Maren Watkins, William Resager, Frank G. Whitby, Dylan Taylor, Helena Safavi-Hemami, Julita S. Imperial

Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6518568b426cd7ed814bbd0c76d09ed8
https://doi.org/10.1101/2021.10.26.465842

Design and Synthesis of 2,3-trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

Autor: Kasper B. Hansen, Mikkel Krell-Jørgensen, Eloi Astier, Younes Larsen, Birgitte Nielsen, Jed T. Syrenne, Christian B. M. Poulie, Anna Alcaide, Feng Yi, Darryl S. Pickering, Morten Storgaard, Walden E. Bjørn-Yoshimoto, Karla Frydenvang, Lennart Bunch, Anders A. Jensen

Publikováno v: ACS Chem Neurosci

Development of pharmacological tools for the ionotropic glutamate receptors (iGluRs) is imperative for the study and understanding of the role and function of these receptors in the central nervous system. We report the synthesis of 18 analogues of (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390076e4d98182631a6a5e9f6f0470f4
https://doi.org/10.1021/acschemneuro.9b00205

The importance of the excitatory amino acid transporter 3 (EAAT3)

Autor: Walden E. Bjørn-Yoshimoto, Suzanne M. Underhill

Publikováno v: Neurochemistry International. 98:4-18

The neuronal excitatory amino acid transporter 3 (EAAT3) is fairly ubiquitously expressed in the brain, though it does not necessarily maintain the same function everywhere. It is important in maintaining low local concentrations of glutamate, where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49b642b783914d1e27499ce10b117ee
https://doi.org/10.1016/j.neuint.2016.05.007