Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Waldemar Popik"'
Autor:
Etty Kruzel-Davila, Ira Bavli-Kertselli, Ayala Ofir, Amber M. Cheatham, Revital Shemer, Eid Zaknoun, Sergiy Chornyy, Orly Tabachnikov, Shamara E. Davis, Atanu K. Khatua, Karl Skorecki, Waldemar Popik
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103717- (2022)
Summary: Two variants at the APOL1 gene, encoding apolipoprotein L1, account for more than 70% of the increased risk for chronic kidney disease in individuals of African ancestry. While the initiating event for APOL1 risk variant cell injury remains
Externí odkaz:
https://doaj.org/article/49c1ce3f9fd0482b80f87bbe2a296490
Publikováno v:
Viruses, Vol 11, Iss 7, p 583 (2019)
Background: BK polyomavirus (BKV) reactivates from latency after immunosuppression in renal transplant patients, resulting in BKV-associated nephropathy (BKVAN). BKVAN has emerged as an important cause of graft dysfunction and graft loss among transp
Externí odkaz:
https://doaj.org/article/fc5e45dc63f34c758a48126004e06289
Autor:
Harry E Taylor, Glenn E Simmons, Thomas P Mathews, Atanu K Khatua, Waldemar Popik, Craig W Lindsley, Richard T D'Aquila, H Alex Brown
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004864 (2015)
Quiescent CD4+ T cells restrict human immunodeficiency virus type 1 (HIV-1) infection at early steps of virus replication. Low levels of both deoxyribonucleotide triphosphates (dNTPs) and the biosynthetic enzymes required for their de novo synthesis
Externí odkaz:
https://doaj.org/article/58ac4f2525f7465eb9d8b436f90e8f0e
Publikováno v:
Virology. 519:77-85
Background Zika virus (ZIKV) infection has been associated with microcephaly in infants. Currently there is no treatment or vaccine. Here we explore the use of a morpholino oligonucleotide targeted to the 5′ untranslated region (5′-UTR) of the ZI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3cb86285023a7b00d91443fa51feb0
https://doi.org/10.1016/j.virol.2018.04.001
https://doi.org/10.1016/j.virol.2018.04.001
Autor:
Kamesh Ayasolla, Xiqian Lan, Leonard G. Meggs, Ali Hussain, Pravin C. Singhal, Abheepsa Mishra, Vinod Kumar, Ashwani Malhotra, Himanshu Vashistha, Sheetal Chowdhary, Rukhsana Aslam, Shadafarin Marashi Shoshtari, Waldemar Popik, Moin A. Saleem, Karl Skorecki, Nitpriya Paliwal
Publikováno v:
American Journal of Physiology-Renal Physiology. 314:F832-F843
The loss of podocyte (PD) molecular phenotype is an important feature of diabetic podocytopathy. We hypothesized that high glucose (HG) induces dedifferentiation in differentiated podocytes (DPDs) through alterations in the apolipoprotein (APO) L1-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2ae6ee118abfaaf69983e5096b6a44
https://doi.org/10.1152/ajprenal.00541.2017
https://doi.org/10.1152/ajprenal.00541.2017
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
APOL1 alleles G1 and G2 are associated with faster progression to lupus nephritis (LN)-associated end-stage renal disease (LN-ESRD) in African Americans. Increased levels of type I interferons (IFNs) and nucleosome-associated double-stranded DNA (dsD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f244c2dc3f88f0272e880472a63f84
https://doi.org/10.1038/s41598-019-51998-w
https://doi.org/10.1038/s41598-019-51998-w
Autor:
Praveen N. Chander, Himanshu Vashistha, Seyedeh Shadafarin Marashi Shoshtari, Mohamed G. Atta, Karl Skorecki, Rukhsana Aslam, Joanna Mikulak, Catherine Meyer-Schwesinger, Nitpriya Paliwal, Nirupama Chandel, Waldemar Popik, Pravin C. Singhal, Ashwani Malhotra, Xiqian Lan, Kamesh Ayasolla, Frank Abbruscato, Vinod Kumar
Human parietal epithelial cells (PECs) are progenitor cells that sustain podocyte homeostasis. We hypothesized that the lack of apolipoprotein (APO) L1 ensures the PEC phenotype, but its induction initiates PEC transition (expression of podocyte mark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0c581f03af15c9d977fa4d1768fdad
https://europepmc.org/articles/PMC6222279/
https://europepmc.org/articles/PMC6222279/
Autor:
Kumar, Chandel N, Shoshtari Sm, Karl Skorecki, Pravin C. Singhal, Lan X, Frank Abbruscato, Joanna Mikulak, Ashwani Malhotra, Waldemar Popik, Paliwal N, Himanshu Vashistha, Ayasolla K, Catherine Meyer-Schwesinger, Aslam R
Human Parietal Epithelial cells (PECs) are considered as a source of progenitor cells to sustain podocyte (PD) homeostasis. We hypothesized that the absence of apolipoprotein (APO) L1 favors the PEC phenotype and that induction of APOL1 transitions t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3129814e1fc66912fcca4f3e838234
https://doi.org/10.1101/259267
https://doi.org/10.1101/259267
Publikováno v:
Journal of translational science
Background Human Cytomegalovirus (HCMV) infection is problematic after kidney transplantation. Human mesangial cells along with human glomerular endothelial cells and podocytes constitute the renal glomerular vascular unit (GVU). HCMV infection of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5660d5876ccb90a26b5612f4466339e
https://doi.org/10.15761/jts.1000248
https://doi.org/10.15761/jts.1000248
Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
APOL1 risk alleles G1 or G2 are associated with a kidney disease phenotype exclusively in people of recent African ancestry. Here we show that exon 4 encoding a part of the APOL1 signal peptide is constitutively spliced in major APOL1 transcripts exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c80ee354a278f23b0cb2978d0f6358
https://pubmed.ncbi.nlm.nih.gov/29880816
https://pubmed.ncbi.nlm.nih.gov/29880816