Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures.

Autor: Thouta S; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Waldbrook MG; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Lin S; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Mahadevan A; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Mezeyova J; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Soriano M; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Versi P; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Goodchild SJ; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada., Parrish RR; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, United States.

Publikováno v: Frontiers in cellular neuroscience [Front Cell Neurosci] 2022 Sep 29; Vol. 16, pp. 964691. Date of Electronic Publication: 2022 Sep 29 (Print Publication: 2022).