Zobrazeno 1 - 10
of 639
pro vyhledávání: '"Walczak, A. M."'
Since the approval of the first antibody drug in 1986, a total of 162 antibodies have been approved for a wide range of therapeutic areas, including cancer, autoimmune, infectious, or cardiovascular diseases. Despite advances in biotechnology that ac
Externí odkaz:
http://arxiv.org/abs/2411.13390
Cells use signalling pathways as windows into the environment to gather information, transduce it into their interior, and use it to drive behaviours. MAPK (ERK) is a highly conserved signalling pathway in eukaryotes, directing multiple fundamental c
Externí odkaz:
http://arxiv.org/abs/2410.22571
The onset of neural induction in the anterior ectoderm of ascidian embryos is regulated at the extracellular level by FGF signaling molecules, which control the acquisition of neural fate through the activation of the ERK pathway. Among the anterior
Externí odkaz:
http://arxiv.org/abs/2410.18143
Autor:
Blot, Natalie, Brooks, Caelan, Swartz, Daniel W., Abdelaleem, Eslam, Garic, Martin, Iglesias-Ramas, Andrea, Pasek, Michael, Mora, Thierry, Walczak, Aleksandra M.
Viruses like influenza have long coevolved with host immune systems, gradually shaping the evolutionary trajectory of these pathogens. Host immune systems develop immunity against circulating strains, which in turn avoid extinction by exploiting anti
Externí odkaz:
http://arxiv.org/abs/2410.17418
Autor:
Abbate, Maria Francesca, Dupic, Thomas, Vigne, Emmanuelle, Shahsavarian, Melody A., Walczak, Aleksandra M., Mora, Thierry
B cell receptors (BCRs) play a crucial role in recognizing and fighting foreign antigens. High-throughput sequencing enables in-depth sampling of the BCRs repertoire after immunization. However, only a minor fraction of BCRs actively participate in a
Externí odkaz:
http://arxiv.org/abs/2312.13465
Autor:
Isacchini, Giulio, Quiniou, Valentin, Vantomme, Hélène, Stys, Paul, Mariotti-Ferandiz, Encarnita, Klatzmann, David, Walczak, Aleksandra M., Mora, Thierry, Nourmohammad, Armita
The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acquired and selected during T cell maturation in the thymus. Characteriz
Externí odkaz:
http://arxiv.org/abs/2307.14376
In many applications in biology, engineering and economics, identifying similarities and differences between distributions of data from complex processes requires comparing finite categorical samples of discrete counts. Statistical divergences quanti
Externí odkaz:
http://arxiv.org/abs/2307.04201
Antigenic variation is the main immune escape mechanism for RNA viruses like influenza or SARS-CoV-2. While high mutation rates promote antigenic escape, they also induce large mutational loads and reduced fitness. It remains unclear how this cost-be
Externí odkaz:
http://arxiv.org/abs/2304.11041
Autor:
Mora, Thierry, Walczak, Aleksandra M.
A cornerstone of the classical view of tolerance is the elimination of self-reactive T cells during negative selection in the thymus. However, high-throughput T-cell receptor sequencing data has so far failed to detect substantial signatures of negat
Externí odkaz:
http://arxiv.org/abs/2303.07163
Biological cells encode information about their environment through biochemical signaling networks that control their internal state and response. This information is often encoded in the dynamical patterns of the signaling molecules, rather than jus
Externí odkaz:
http://arxiv.org/abs/2301.03907