Výsledky vyhledávání - "Walairat Laosinchai-Wolf"

Multisite Evaluation and Validation of a Sensitive Diagnostic and Screening System for Spinal Muscular Atrophy that Reports SMN1 and SMN2 Copy Number, along with Disease Modifier and Gene Duplication Variants

Autor: Huiping Zhu, Gary J. Latham, Jessica L. Larson, Ya-Wen Huang, Caren Gentile, Henny H. Lemmink, Johanna Schleutker, Tsang-Ming Ko, Vivianna M. Van Deerlin, Kristin M. Abbott, Minna Toivonen, John N. Milligan, Walairat Laosinchai-Wolf, Stela Filipovic-Sadic

Publikováno v: Journal of molecular diagnostics, 23(6), 753-764. ELSEVIER SCIENCE INC
J Mol Diagn

Spinal muscular atrophy is a severe autosomal recessive disease caused by disruptions in the SMN1 gene. The nearly identical SMN2 gene copy number is associated with disease severity. SMN1 duplication markers, such as c.*3+80T>G and c.*211_*212del, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ec57853e976c37d5479aa151cdc6c1
https://research.rug.nl/en/publications/d7553b59-7a1d-4848-95cc-0efe7d7b1c4d

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Analytical Validation of a Highly Sensitive, Multiplexed Chronic Myeloid Leukemia Monitoring System Targeting BCR-ABL1 RNA

Autor: Walairat Laosinchai-Wolf, Ion Beldorth, Fei Yang, John B. Hedges, Jacquelyn J. Roth, Adam K. Ruskin, Keri L. Jefferson, Justin T Brown, Bernard F. Andruss, L Cai, Richard D. Press, Marie E. Fahey, Christopher D. Watt

Publikováno v: The Journal of Molecular Diagnostics : JMD

This study describes the analytical performance of the QuantideX qPCR BCR-ABL IS Kit, the first Food and Drug Administration–cleared assay designed to monitor breakpoint cluster region–Abelson tyrosine-protein kinase 1 (BCR-ABL1) fusion transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce6e5d892b5ee7710e3b7e59946a61d
https://pubmed.ncbi.nlm.nih.gov/31026597

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An optimized isolation and labeling platform for accurate microRNA expression profiling

Autor: Jaclyn Shingara, Kerri Keiger, Emmanuel Labourier, Jeffrey Shelton, Walairat Laosinchai-Wolf, Richard Conrad, David Brown, Patricia Powers

Publikováno v: RNA. 11:1461-1470

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression in both plants and animals. miRNA genes have been implicated in a variety of important biological processes, including development, differentiation, apoptosis, fat metabolism,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c94c9236060f530aebcf964303a67af
https://doi.org/10.1261/rna.2610405

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Microsphere Bead Arrays and Sequence Validation of 5/7/9T Genotypes for Multiplex Screening of Cystic Fibrosis Polymorphisms

Autor: Chris R. Novak, Marianna Goldrick, Cindy R. WalkerPeach, Marty R. Badgett, Walairat Laosinchai-Wolf, Andrew G. Hadd, Lesley A. Isgur

Publikováno v: The Journal of Molecular Diagnostics. 6:348-355

The development of simple and rapid methods for the detection of the common genetic mutations associated with cystic fibrosis (CF) requires access to positive-control samples including the 5/7/9T variants of intron 8. We used PCR and a simple multipl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bb1a72d7c1efd2a418ca2bda60274c
https://doi.org/10.1016/s1525-1578(10)60531-4

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Molecular testing for oncogenic gene mutations in thyroid lesions: a case-control validation study in 413 postsurgical specimens

Autor: Rupali Shinde, Emmanuel Labourier, Laura Langfield, Thomas J. Giordano, Sylvie Beaudenon-Huibregtse, Michelle Vinco, Walairat Laosinchai-Wolf

Publikováno v: Human pathology. 45(7)

Molecular testing for oncogenic gene alterations provides clinically actionable information essential for the optimal management of follicular cell thyroid cancer. We aimed to establish the distribution and frequency of common oncogenic gene mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea58aa8755c00683439313166fbb95e
https://pubmed.ncbi.nlm.nih.gov/24830619

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A multiplex technology platform for the rapid analysis of clinically actionable genetic alterations and validation for BRAF p.V600E detection in 1549 cytologic and histologic specimens

Autor: Richard Sesboüé, David L. Smith, Sylvie Beaudenon-Huibregtse, Jean-Christophe Sabourin, Emmanuel Labourier, Walairat Laosinchai-Wolf, Aude Lamy

Publikováno v: Archives of pathologylaboratory medicine. 138(3)

Context.—Current clinicopathologic assessment of malignant neoplastic diseases entails the analysis of specific genetic alterations that provide diagnostic, prognostic, or therapy-determining information.Objective.—To develop and validate a robus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e35572b1cd669c782cffaf126b5821
https://pubmed.ncbi.nlm.nih.gov/23808402

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Risk-based classification of leukemia by cytogenetic and multiplex molecular methods: results from a multicenter validation study

Autor: L Brusca, C Higgs, Q Wei, L. Friar, Emmanuel Labourier, Mike Griffiths, Walairat Laosinchai-Wolf, J Mason, A Masters, H Newell, Christopher D. Gocke, Judith E. Karp

Publikováno v: Blood Cancer Journal

Modern management of leukemia and selection of optimal treatment approaches entails the analysis of multiple recurrent cytogenetic abnormalities with independent diagnostic or prognostic value. We report the first multicenter validation of a multiple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b16b3f640d1e0ab3a955ce269e63cd
https://pubmed.ncbi.nlm.nih.gov/22852047

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An optimized technology platform for the rapid multiplex molecular analysis of genetic alterations associated with leukemia

Autor: Fei Ye, Emmanuel Labourier, Walairat Laosinchai-Wolf

Publikováno v: Cancer genetics. 205(10)

Molecular methods play a critical role in the accurate diagnosis of leukemia by complementing morphologic, cytochemical, immunophenotypic, and cytogenetic analyses. We developed a multiplex reverse transcription–polymerase chain reaction (RT-PCR) m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31355e49023e6fe41f4400026f1b9cb3
https://pubmed.ncbi.nlm.nih.gov/23026076

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