Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Walaa Ibraheem"'
1
Akademický článek
Exploring the potential of approved drugs for triple-negative breast cancer treatment by targeting casein kinase 2: Insights from computational studies.
Autor: Tagyedeen H Shoaib, Walaa Ibraheem, Mohammed Abdelrahman, Wadah Osman, Asmaa E Sherif, Ahmed Ashour, Sabrin R M Ibrahim, Kholoud F Ghazawi, Samar F Miski, Sara A Almadani, Duaa Fahad ALsiyud, Gamal A Mohamed, Abdulrahim A Alzain
Publikováno v: PLoS ONE, Vol 18, Iss 8, p e0289887 (2023)
Triple-negative breast cancer (TNBC) is an aggressive malignancy that requires effective targeted drug therapy. In this study, we employed in silico methods to evaluate the efficacy of seven approved drugs against human ck2 alpha kinase, a significan
Externí odkaz: https://doaj.org/article/99f11dd1bb524588ac12f2ab846f503d
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2
Akademický článek
Repurposing of approved drugs for targeting CDK4/6 and aromatase protein using molecular docking and molecular dynamics studies.
Autor: Fatima A Yousif, Abdulrahim A Alzain, Alhafez M Alraih, Walaa Ibraheem
Publikováno v: PLoS ONE, Vol 18, Iss 9, p e0291256 (2023)
Breast cancer is a leading cause of cancer-related morbidity and mortality worldwide, with the highest incidence among women. Among the various subtypes of breast cancer, estrogen-receptor positive (ER+) is the most diagnosed. Estrogen upregulates cy
Externí odkaz: https://doaj.org/article/fd7abcfbeb4c43d2a633024ef1ad3f62
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3
Akademický článek
Design of Novel Phosphatidylinositol 3-Kinase Inhibitors for Non-Hodgkin’s Lymphoma: Molecular Docking, Molecular Dynamics, and Density Functional Theory Studies on Gold Nanoparticles
Autor: Abdalrahim M. Ali, Alaa A. Makki, Walaa Ibraheem, Mohammed Abdelrahman, Wadah Osman, Asmaa E. Sherif, Ahmed Ashour, Sabrin R. M. Ibrahim, Kholoud F. Ghazawi, Waad A. Samman, Abdulrahim A. Alzain
Publikováno v: Molecules, Vol 28, Iss 5, p 2289 (2023)
Non-Hodgkin’s lymphomas are a diverse collection of lymphoproliferative cancers that are much less predictable than Hodgkin’s lymphomas with a far greater tendency to metastasize to extranodal sites. A quarter of non-Hodgkin’s lymphoma cases de
Externí odkaz: https://doaj.org/article/43e82ed9dd3a49ebb431fb18fa4b3227
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4
Akademický článek
Drug repurposing for SARS-CoV-2 main protease: Molecular docking and molecular dynamics investigations
Autor: Samia E. Omer, Tawasol M. Ibrahim, Omer A. Krar, Amna M. Ali, Alaa A. Makki, Walaa Ibraheem, Abdulrahim A. Alzain
Publikováno v: Biochemistry and Biophysics Reports, Vol 29, Iss , Pp 101225- (2022)
The current novel corona virus illness (COVID-19) is a developing viral disease that was discovered in 2019. There is currently no viable therapeutic strategy for this illness management. Because traditional medication development and discovery has l
Externí odkaz: https://doaj.org/article/c870066b82b544209b15c30fd1a431e2
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5
Akademický článek
Identification of Novel Natural Dual HDAC and Hsp90 Inhibitors for Metastatic TNBC Using e-Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Studies
Autor: Nihal AbdElmoniem, Marwa H. Abdallah, Rua M. Mukhtar, Fatima Moutasim, Ahmed Rafie Ahmed, Alaa Edris, Walaa Ibraheem, Alaa A. Makki, Eman M. Elshamly, Rashid Elhag, Wadah Osman, Ramzi A. Mothana, Abdulrahim A. Alzain
Publikováno v: Molecules, Vol 28, Iss 4, p 1771 (2023)
Breast cancer (BC) is one of the main types of cancer that endangers women’s lives. The characteristics of triple-negative breast cancer (TNBC) include a high rate of recurrence and the capacity for metastasis; therefore, new therapies are urgently
Externí odkaz: https://doaj.org/article/571031684cb04afc8dd8885163973b9e
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6
Akademický článek
Identification of novel transmembrane Protease Serine Type 2 drug candidates for COVID-19 using computational studies
Autor: Fatima A. Elbadwi, Elaf A. Khairy, Fatima O. Alsamani, Mariam A. Mahadi, Segood E. Abdalrahman, Zain Alsharf M. Ahmed, Inas Elsayed, Walaa Ibraheem, Abdulrahim A. Alzain, PhD
Publikováno v: Informatics in Medicine Unlocked, Vol 26, Iss , Pp 100725- (2021)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emergence has resulted in a global health crisis. As a consequence, discovering an effective therapy that saves lives and slows the spread of the pandemic is a global concern currently. In
Externí odkaz: https://doaj.org/article/1541eebb223348ab828fa04903012f52
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7
Akademický článek
Design of novel coumarins as potent Mcl-1 inhibitors for cancer treatment guided by 3D-QSAR, molecular docking and molecular dynamics
Autor: Esraa Albasher Osman, Mohammed Abdalrahman Abdalla, Mohja Omer Abdelraheem, Mubarak Fadlalla Ali, Shima Albasher Osman, Yasmin Mohamed Tanir, Mohammed Abdelrahman, Walaa Ibraheem, Abdulrahim A. Alzain
Publikováno v: Informatics in Medicine Unlocked, Vol 26, Iss , Pp 100765- (2021)
Myeloid cell leukemia-1 (Mcl-1) is a protein that belongs to a large group of proteins called B cell lymphoma-2 (Bcl-2) which are involved in controlling of apoptosis via interacting with other Bcl-2 family. Various studies showed that Mcl-1 is overe
Externí odkaz: https://doaj.org/article/f8c58dc726ae4a449fff658dd4dc9b2b
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9
Cytosporone E analogues as BRD4 inhibitors for cancer treatment: molecular docking and molecular dynamic investigations
Autor: Alaa A. Makki, Walaa Ibraheem, Abdulrahim A. Alzain
Cancer is considered one of the worldwide life-threatening and leading causes of human mortality. In 2020, 19,292,789 cancer cases and 9,958,133 cancer deaths have been estimated worldwide. Therefore, efforts have been devoted to discover novel antic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413efa9466503fbc78c341fe67bf7ac7
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