Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Walaa Hamada Abd-Allah"'
Autor:
Mohammed Farrag El-Behairy, Walaa Hamada Abd-Allah, Mohamed M. Khalifa, Mohamed S. Nafie, Mohamed A. Saleh, Mohammed S. Abdel-Maksoud, Tarfah Al-Warhi, Wagdy M. Eldehna, Ahmed A. Al‐Karmalawy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
In this research, two novel series of dibenzo[b,f]azepines (14 candidates) were designed and synthesised based on the rigidification principle and following the reported doxorubicin’s pharmacophoric features. The anti-proliferative activity was eva
Externí odkaz:
https://doaj.org/article/c4fb055b92c24a3eb4000d2f73075561
Autor:
Ashgan F. Mahmoud, Mohamed H. Aboumanei, Walaa Hamada Abd-Allah, Mohamed M. Swidan, Tamer M. Sakr
Publikováno v:
International Journal of Radiation Biology. 99:281-291
As the 'Resveratrol was radiolabeled with radioactive iodine where the radioiodination efficiency was enlightened and the computational approaches were employed to investigate the affinity and specificity with tubulins. Furthermore, the in-vivo distr
Autor:
Walaa Hamada Abd-Allah, Mostafa Abd El-Mohsen Anwar, Eman R. Mohammed, Marawan A. Elbaset, Samir M. El Moghazy
Publikováno v:
Bioorganic Chemistry. 136:106561
Autor:
Mohammed Farrag El-Behairy, Ahmed H. Tantawy, Adel A. Marzouk, Walaa Hamada Abd-Allah, Man-Qun Wang, Hong Jiang
Publikováno v:
Journal of Medicinal Chemistry. 64:17468-17485
Highly fluorinated candidates containing anticancer pharmacophores like thiosemicarbazone (5a-e) and its cyclic analogues hydrazineylidenethiazolidine (6a-e), 2-aminothiadiazole (7a-e), and 2-hydrazineylidenethiazolidin-4-one (8a-e) were synthesized,
Publikováno v:
Drug Development Research. 80:933-947
Novel 1,1-disubstituted cyclohexane-1-carboxamides 6a-h, 7a-e, and 8a-b were designed and synthesized as apoptotic inducers. Cytotoxicity test revealed that some compounds have strong to moderate effect, while others displayed weak action against dif
Autor:
Ehab S. Taher, Mohammed Farrag El-Behairy, Walaa Hamada Abd-Allah, Adel Mohamed Aboregela, Adel A. Marzouk, Ping Lan, Montaser Sh. A. Shaykoon
Publikováno v:
Bioorganic chemistry. 111
A novel series of thiazolo-pyrazole hybrids has been prepared and assessed for their in vitro COX-1/COX-2 inhibitory activity. Compound 6c exhibited the most selective COX-2 inhibition profile (SI of 264) not far of Celecoxib (2 9 4). In-vivo anti-in
Publikováno v:
Oriental Journal of Chemistry. 34:825-833
Publikováno v:
Bioorganic Chemistry. 71:135-145
A series of (1-(benzyl (aryl) amino) cyclohexyl) methyl esters 7a-n were prepared and screened for their anticonvulsant profile. Screening of these esters 7a-n and their starting alcohols 6a and 6b revealed that compound 7k was the most potent one in
Autor:
Walaa Hamada Abd-Allah, Mohamed Nabil Aboul-Enein, Aida A. El-Azzouny, Mona E Aboutabl, Rasha M. Hassan
Publikováno v:
Bioorganic chemistry. 94
In this work a set of novel derivatives of parabanic acid 9a-d, 12a-d and 13a-d was synthesized and their anticonvulsant potential was evaluated. All the compounds under investigation exhibited anticonvulsant activity in both scPTZ and MES tests. In
Autor:
Mohamed Nabil Aboul-Enein, Walaa Hamada Abd-Allah, Aida A. El-Azzouny, Asmaa Mohamed Salman, Rasha M. Hassan
Publikováno v:
European Journal of Pharmaceutical Sciences. 139:105045
A new set of 1,3-benzodioxoles and 1,4-benzodioxines was designed and synthesized starting from gallic acid as anticancer agents. The antiproliferative effect of the target compounds was evaluated against a panel of cancer cell lines (HepG2, PC-3, MC