Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Wakatsuki Pedersen A"'
Autor:
Inés Lecoq, Katharina L. Kopp, Marion Chapellier, Panagiotis Mantas, Evelina Martinenaite, Maria Perez-Penco, Lars Rønn Olsen, Mai-Britt Zocca, Ayako Wakatsuki Pedersen, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T cells through the CCL22:CCR4 axis. CCL22 was shown to play a key role in suppressing anti-cancer immune responses in different cancer types. Recently, we showed that
Externí odkaz:
https://doaj.org/article/4deb28186bcd4fa28e4ce8cd2df20145
Autor:
Cathrine Lund Lorentzen, Evelina Martinenaite, Julie Westerlin Kjeldsen, Rikke Boedker Holmstroem, Sofie Kirial Mørk, Ayako Wakatsuki Pedersen, Eva Ehrnrooth, Mads Hald Andersen, Inge Marie Svane
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundArginase-1-producing cells inhibit T cell-mediated anti-tumor responses by reducing L-arginine levels in the tumor microenvironment. T cell-facilitated elimination of arginase-1-expressing cells could potentially restore L-arginine levels a
Externí odkaz:
https://doaj.org/article/0746d310421f4a54b6021f1392b47672
Autor:
Mads Hald Andersen, Özcan Met, Ayako Wakatsuki Pedersen, Inge Svane, Evelina Martinenaite, Mia Aaboe Jørgensen, Rasmus Erik Johansson Mortensen, Shamaila Munir Ahmad, Stine Emilie Weis-Banke, Morten Orebo Holmström
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/25710882e4574c84a62f97f30e132dc4
Autor:
Mads Hald Andersen, Souvik Dey, Erika Sutanto-Ward, Katharina L Kopp, James DuHadaway, Arpita Mondal, Dema Ghaban, Inés Lecoq, Mai-Britt Zocca, Lauren M F Merlo, Laura Mandik-Nayak, Ayako Wakatsuki Pedersen, Alexander J Muller
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpre
Externí odkaz:
https://doaj.org/article/85b92312e7ef499e81e377e49eedf1d5
Autor:
Stine Emilie Weis-Banke, Mie Linder Hübbe, Morten Orebo Holmström, Mia Aaboe Jørgensen, Simone Kloch Bendtsen, Evelina Martinenaite, Marco Carretta, Inge Marie Svane, Niels Ødum, Ayako Wakatsuki Pedersen, Özcan Met, Daniel Hargbøl Madsen, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence of pro-inflammatory effector T-cells that recognize ARG2 and can directly target
Externí odkaz:
https://doaj.org/article/ea0ac61138cc45ada890530c9c9af0c1
Autor:
Rahul Nandre, Vivek Verma, Pankaj Gaur, Veerupaxagouda Patil, Xingdong Yang, Zainab Ramlaoui, Nour Shobaki, Mads Hald Andersen, Ayako Wakatsuki Pedersen, Mai-Britt Zocca, Mikayel Mkrtichyan, Seema Gupta, Samir N. Khleif
Publikováno v:
Cancer Immunology Research. 10:571-580
The immunosuppressive tumor microenvironment (TME) does not allow generation and expansion of antitumor effector cells. One of the potent immunosuppressive factors present in the TME is the indoleamine-pyrrole 2,3-dioxygenase (IDO) enzyme, produced m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4a9bb2631cd48b13fafc2cf76179bb
https://doi.org/10.1158/2326-6066.cir-21-0457
https://doi.org/10.1158/2326-6066.cir-21-0457
Autor:
Samir N. Khleif, Seema Gupta, Mikayel Mkrtichyan, Mai-Britt Zocca, Ayako Wakatsuki Pedersen, Mads Hald Andersen, Nour Shobaki, Zainab Ramlaoui, Xingdong Yang, Veerupaxagouda Patil, Pankaj Gaur, Vivek Verma, Rahul Nandre
Supplementary Figure from IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edd7ca342d91a9cef7de4a043847aee
https://doi.org/10.1158/2326-6066.22544379.v1
https://doi.org/10.1158/2326-6066.22544379.v1
Autor:
Mads Hald Andersen, Vincenzo Bronte, Ayako Wakatsuki Pedersen, Daniel Hargbøll Madsen, Mai-Britt Zocca, Manuela Iezzi, Cristina Frusteri, Francesco De Sanctis, Annalisa Adamo, Marion Chapellier, Katharina Kopp, Evelina Martinenaite, Stine Emilie Weis-Banke, Maria Perez-Penco, Marco Carretta, Mie Linder Hübbe, Stefano Ugel, Mia Aaboe Jørgensen
Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity of ARG1 promotes the formation of an immunosuppressive microenvironment and leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666a35b5cf78d8cf2f4835377ed3e14d
https://doi.org/10.1158/2326-6066.c.6550574
https://doi.org/10.1158/2326-6066.c.6550574
Autor:
Samir N. Khleif, Seema Gupta, Mikayel Mkrtichyan, Mai-Britt Zocca, Ayako Wakatsuki Pedersen, Mads Hald Andersen, Nour Shobaki, Zainab Ramlaoui, Xingdong Yang, Veerupaxagouda Patil, Pankaj Gaur, Vivek Verma, Rahul Nandre
The immunosuppressive tumor microenvironment (TME) does not allow generation and expansion of antitumor effector cells. One of the potent immunosuppressive factors present in the TME is the indoleamine-pyrrole 2,3-dioxygenase (IDO) enzyme, produced m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ee05cf106a5bc42dc9b17ba076c0e8
https://doi.org/10.1158/2326-6066.c.6550626
https://doi.org/10.1158/2326-6066.c.6550626
Autor:
Mads Hald Andersen, Özcan Met, Marco Donia, Evelina Martinenaite, Simone Kloch Bendtsen, Mia Aaboe-Jørgensen, Inge Marie Svane, Ayako Wakatsuki Pedersen, Morten Orebo Holmström, Angelos Michail Pavlidis, Stine Emilie Weis-Banke, Rasmus Erik Johansson Mortensen
Publikováno v:
Cell Mol Immunol
Transforming growth factor-beta (TGFβ) is a highly potent immunosuppressive cytokine. Although TGFβ is a tumor suppressor in early/premalignant cancer lesions, the cytokine has several tumor-promoting effects in advanced cancer; abrogation of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3c0673a45bb8d500586bc55720eb1c
https://doi.org/10.1038/s41423-020-00593-5
https://doi.org/10.1038/s41423-020-00593-5