Výsledky vyhledávání - "Wakana MATSUMURA"

The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes

Autor: Hiroshi Shimizu, Yasuyuki Fujita, Toshifumi Nomura, Wakana Matsumura, Inkin Ujiie, Shota Takashima, Satoru Shinkuma, Chihiro Nakayama, Riichiro Abe

Publikováno v: Journal of Dermatological Science. 91:301-310

Background Epidermolysis bullosa (EB) is a group of hereditary disorders caused by mutations in the genes encoding structural molecules of the dermal-epidermal junction (DEJ). Cell-based therapies such as allogeneic mesenchymal stem/stromal cell (MSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec9d73e29010c3864b8f445541e719e
https://doi.org/10.1016/j.jdermsci.2018.06.004

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Establishment of integration-free induced pluripotent stem cells from human recessive dystrophic epidermolysis bullosa keratinocytes

Autor: Riichiro Abe, Chihiro Nakayama, Toshifumi Nomura, Hiroshi Shimizu, Wakana Matsumura, Yasuyuki Fujita, Satoru Shinkuma, Shotaro Suzuki

Publikováno v: Journal of Dermatological Science. 89:263-271

Background Induced pluripotent stem cell (iPSC) technology enables patient-specific pluripotent stem cells to be derived from adult somatic cells without the use of an embryonic cell source. To date, recessive dystrophic epidermolysis bullosa (RDEB)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c5b8e48113aae46586d8ddc8572c2a
https://doi.org/10.1016/j.jdermsci.2017.11.017

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Altered balance of epidermis-related chemokines in epidermolysis bullosa

Autor: Chihiro Nakayama, Wakana Matsumura, Inkin Ujiie, Satoru Shinkuma, Shotaro Suzuki, Toshifumi Nomura, Yasuyuki Fujita, Hiroshi Shimizu, Riichiro Abe

Publikováno v: Journal of dermatological science. 86(1):37-45

Background Epidermolysis bullosa (EB) is a congenital, refractory skin disease and there are no fundamental treatments. Recently, allogenic cell therapies are beginning to be applied as potential treatments, that are based on the concept that the all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c0cef037b39eaa35637e435f27b7ca
http://hdl.handle.net/2115/68661

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Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes

Autor: Wakana Matsumura, Tomoki Kabeya, Takahiro Iwao, Tamihide Matsunaga, Masakiyo Hosokawa

Publikováno v: Biochemical and biophysical research communications. 486(1)

Human carboxylesterase (CES) is a key esterase involved in the metabolism and biotransformation of drugs. Hydrolysis activity in the human small intestine is predominantly mediated by CES2A1 rather than CES1A. In drug development studies, Caco-2 cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc8f31d476a61f3012ac72f9ca37a7e
https://pubmed.ncbi.nlm.nih.gov/28285137

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Cultured Epidermal Autografts from Clinically Revertant Skin as a Potential Wound Treatment for Recessive Dystrophic Epidermolysis Bullosa

Autor: Masukazu Inoie, Saki Yokoshiki, Yasuyuki Fujita, Toshifumi Nomura, Kota Ono, Norihiro Sato, Hiroshi Shimizu, Hideki Nakamura, Riichiro Abe, Satoru Shinkuma, Shotaro Suzuki, Hiroshi Hayashi, Shota Takashima, Chihiro Nakayama, Hideki Goto, Wakana Matsumura

Publikováno v: Journal of Investigative Dermatology. 139:2115-2124.e11

Inherited skin disorders have been reported recently to have sporadic normal-looking areas, where a portion of the keratinocytes have recovered from causative gene mutations (revertant mosaicism). We observed a case of recessive dystrophic epidermoly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c527573c408a78e9a34003bb3c439ada
https://doi.org/10.1016/j.jid.2019.03.1155

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