Výsledky vyhledávání

Effects of adenosine on optic nerve head circulation in rabbits

Autor: Tetsuya Sugiyama, Wakana Goto, Tsunehiko Ikeda, Takatoshi Kobayashi, Hidehiro Oku, Mami Hirao

Publikováno v: Experimental Eye Research. 79:729-735

This study was performed to determine whether intravitreal or intravenous adenosine can alter the microcirculation in the optic nerve head (ONH) of rabbits. Capillary blood flow in the ONH was measured serially with a laser speckle tissue analyser fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92ea4620851866f1907343512e481c3
https://doi.org/10.1016/j.exer.2004.08.008

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Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures

Autor: Wakana Goto, Hideaki Hara, Masaki Ichikawa, Makoto Araie, Etsuko Tanaka

Publikováno v: Brain Research. 1003:130-137

To study neuroprotective effects of bunazosin hydrochloride which is an alpha(1)-adrenoceptor antagonist used as an ocular hypotensive drug compared to other alpha(1)-adrenoceptor antagonists, and its mechanism of action. We evaluated the neuroprotec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6fbf96f20edb3c2ebf7a4a23fa24af
https://doi.org/10.1016/j.brainres.2003.12.030

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Adenosine protects cultured retinal neurons against NMDA-induced cell death through A1 receptors

Autor: Tetsuya Sugiyama, Takashi Okuno, Wakana Goto, Hidehiro Oku, Hideaki Hara, Shinji Yoneda, Tsunehiko Ikeda, Takatoshi Kobayashi, Mami Hirao

Publikováno v: Current Eye Research. 29:449-455

To determine whether adenosine can protect cultured retinal neurons, consisting mainly of amacrine cells, from N-methyl-D-aspartate (NMDA)-induced neurotoxicity, and to determine whether agonists and antagonists of adenosine receptors also have a pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9ed3e3a9d8dddf4557181b2f3ff141
https://doi.org/10.1080/02713680490522443

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Interleukin-1β Mediates Ischemic Injury in the Rat Retina

Autor: Shinji Yoneda, Hidenobu Tanihara, Wakana Goto, Hideaki Hara, Noriaki Kido, Yoshihito Honda, Nobuaki Miyawaki

Publikováno v: Experimental Eye Research. 73:661-667

Two types of experiment were performed to examine the role of interleukin-1beta in ischemia-induced damage in the rat retina. In the in vivo study, enzyme-linked immunosorbent assay was used to investigate the expression of immunoreactive interleukin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541cc742d7e3014c11f889aa7a82fcdf
https://doi.org/10.1006/exer.2001.1072

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Suppression of Hepatitis B Virus Surface Antigen Secretion by Traditional Plant Medicines

Autor: Mashahiko Kurokawa, Ines Tomoco Kusumoto, Shigetoshi Kadota, Wakana Goto, Tsuneo Namba, Kimiyasu Shiraki

Publikováno v: Phytotherapy Research. 10:504-507

Forty-three extracts of herbal medicines were tested for suppressing the secretion of hepatitis B virus (HBV) surface antigen (HBsAg) in vitro. Fourteen extracts were found to have appreciable effects in the experimental system using the PLC/PRF/5 ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec90f00fc2d879a2943018c035fa20b6
https://doi.org/10.1002/(sici)1099-1573(199609)10:6<504::aid-ptr894>3.0.co

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Therapeutic basis of glycyrrhizin on chronic hepatitis B

Autor: Seiji Kageyama, Wakana Goto, Hitoshi Sato, Jun-ichi Yamamura, Kimiyasu Shiraki, Akiharu Watanabe, Terumi Takahara, Masahiko Kurokawa

Publikováno v: Antiviral Research. 30:171-177

Glycyrrhizin, a major component of a herb (licorice), has been intravenously used for the treatment of chronic hepatitis B in Japan and improves liver function with occasional complete recovery from hepatitis. This substance modifies the intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ece8c780e67fa0889eb76682d48b042
https://doi.org/10.1016/0166-3542(96)00942-4

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Vertebral fracture status and the World Health Organization risk factors for predicting osteoporotic fracture risk in Japan

Autor: Etsuro Hamaya, Kyoji Furukawa, Toshitaka Nakamura, Akimitsu Miyauchi, Saeko Fujiwara, Naomi Masunari, Peiqi Chen, Masao Fukunaga, Wakana Goto

Publikováno v: Bone. 49(3)

Introduction Vertebral fractures are the most common osteoporotic fracture and the prevalence of vertebral fracture is commonly assessed in clinical practice in Japan. The objective of this study was to evaluate potential risk factors for osteoporoti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909168f8cd6b3db9bb0a744da4ed2ab4
https://pubmed.ncbi.nlm.nih.gov/21652001

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Safety and effectiveness profile of raloxifene in long-term, prospective, postmarketing surveillance

Autor: Wakana Goto, Etsuro Hamaya, Masanori Taketsuna, Shunji Yokoyama, Akimitsu Miyauchi, Noriko Iikuni, Shigeru Nihojima, Hideaki Sowa

Publikováno v: Journal of bone and mineral metabolism. 30(6)

This large-scale postmarketing surveillance of raloxifene (60 mg/day) was conducted to assess the safety and effectiveness of raloxifene for long-term use in postmenopausal Japanese women with osteoporosis. The baseline examination included 6,967 wom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5701854456a158cda94d5734ac9a8964
https://pubmed.ncbi.nlm.nih.gov/22752125

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Amelioration of endothelin-1-induced optic nerve head ischemia by topical bunazosin

Autor: Tetsuya Sugiyama, Tsunehiko Ikeda, Hidehiro Oku, Takashi Okuno, Wakana Goto

Publikováno v: Current eye research. 30(2)

To investigate the effects of bunazosin hydrochloride, an alpha1-adrenergic blocker, on the impairment of optic nerve head (ONH) blood flow and depression of visual function induced by repeated intravitreal injections of endothelin-1 (ET-1) in rabbit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cdbbfe245ae4ec8cf1a28fb5f76fd9
https://pubmed.ncbi.nlm.nih.gov/15814466

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